Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a β1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 20350-20360

  Xia, Hong ^a   Nho, Richard ^a   Kleidon, Jill ^a   Kahm, Judy ^a   Henke, Craig A ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL REACTIONS; CONTROL THEORY; FEEDBACK; FIBROBLASTS; PHASE TRANSITIONS; PHOSPHORYLATION; POLYMERS; TISSUE;

CONSTITUTIVELY ACTIVES; FIBROBLAST PROLIFERATIONS; INTEGRIN; MOLECULAR MECHANISMS; NEGATIVE FEEDBACK LOOPS; OVEREXPRESSION; PHOSPHATIDYLINOSITOL; PROTEIN PHOSPHATASES; TUBEROUS SCLEROSES;

COLLAGEN;

BETA1 INTEGRIN; COLLAGEN; ENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN SUBUNIT; S6K1; TUBERIN; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOSERINE; PHOSPHOTHREONINE; S6 KINASE; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL INTERACTION; CELL PROLIFERATION; ENZYME REPRESSION; ENZYME SUBSTRATE; FIBROBLAST; HUMAN; HUMAN CELL; INHIBITION KINETICS; PHASE TRANSITION; PHOSPHORYLATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; UPREGULATION; CELL ADHESION; CELL LINE; ENZYME ACTIVATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD29; CELL ADHESION; CELL LINE; CELL PROLIFERATION; COLLAGEN; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; NEOPLASMS; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN BINDING; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS;

EID: 50649107998     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707489200     Document Type: Article

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