The effects of barium, dofetilide and 4-aminopyridine (4-AP) on ventricular repolarization in normal and hypertrophied rabbit heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 1, 1998, Pages 262-270

  Gillis, Anne M ^a,c   Geonzon, Radzfel A ^a,b   Mathison, Heather J ^a   Kulisz, Ela ^a   Lester, Wanda M ^a   Duff, Henry J ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b ALBERTA ENVIRONMENT AND PARKS   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; BARIUM; DOFETILIDE; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART HYPERTROPHY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEMODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0031958162     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, DiDiego JM, Gintant GA and Liu DW (1991) Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial and M cells. Circ Res 69:1427-1449.
2. Aronson RS (1980) Characteristics uf action potentials of hypertrophied myocardium from rats with renal hypertension. Circ Res 47:443-454.
3. Aronson RS (1991) Mechanisms of arrhythmias in ventricular hypertrophy. J Cardiovasc Electrophysiol 2:249-261.
4. Benitah JP, Gomez AM, Bailly P, DaPonte J-P, Berson G, Delgado C and Lorente P (1993) Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. J Physiol 469:111-138.
5. + currents from patients with terminal heart failure. Circ Res 73:379-385.
6. Bril A, Forest M-C and Gout B (1991) Ischemia and reperfusion-induced arrhythmias in rabbits with chronic heart failure. Am J Physiol 261:H301-H307.
7. Brooksby P, Levi AJ and Jones JV (1993) The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J Hypertens 11:611-622.
8. Cameron JS, Myerburg RJ, Wong SS, Gaide MS, Epstein K, Alvarez TR, Gelband H, Guse PA and Bassett AL (1983) Electrophysiologic consequences of chronic experimentally induced left ventricular pressure overload. J Am Coll Cardiol 2:481-487.
9. Campbell DL, Rasmussen RL, Ou Y and Strauss HC (1993) The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis, J Gen Physiol 101: 571-601.
10. + current by almokalant in rabbit ventricular myocytes. Circ Res 73: 857-868.
11. Cerbai E, Barbieri M and Mugeli A (1994) Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovasc Res 28:1180-1187.
12. Dean JW and Lab MJ (1990) Regional changes in ventricular excitability during load manipulation of the in situ pig heart. J Physiol 429:387-400.
13. Fedida D and Giles WR (1991) Regional variations in action potential and transient outward current in myocytes isolated from rabbit left ventricle, J Physiol 442:191-209.
14. Franz MR (1996) Mechano-electrical feedback in ventricular myocardium. Cardiovasc Res 32:15-24.
15. + currents in feline left ventricular hypertrophy. Am J Physiol 266:H1121-H1131.
16. Giles WR and Imaizumi Y (1988) Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol 405:123-145.
17. Gillis AM, Kulisz E and Mathison HJ (1996a) Comparison of cardiac electrophysiologic variables in blood perfused and buffer perfused isolated working rabbit hearts. Am J Physiol 271:H784-H789.
18. Gillis AM, Lester WM and Keashly R (1991) Propafenone disposition and pharmacodynamics in normal and norepinephrine-induccd cardiomyopathic rabbit hearts. J Pharmacol Exp Ther 258:722-727.
19. Gillis AM, Mathison HJ, Patel C and Lester WM (1996b) Quinidine pharmacodynamics in normal and isoproterenol-induced hypertrophied blood-perfused working rabbit hearts. J Cardiovasc Pharmacol 27:916-926.
20. Hansen DE (1993) Mechanoelectrical feedback. Effects of altering preload, afterload and ventricular shortening. Am J Physiol 264:H423-H432.
21. Hart G (1994) Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc Res 28:933-946.
22. + currents in fetal, neonatal and adult rabbit ventricular myocytes. Circ Res 70:508-515.
23. Hoshino T, Fujiwara H, Kawai C and Hamashima Y (1983) Myocardial fiber diameter and regional distribution in the ventricular wall of normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy. Circulation 67:1109-1116.
24. + current by dofetilide. Circ Res 72:75-83.
25. Keung EC (1989) Calcium current is increased in isolated adult myocytes from hypertrophied rat myocardium. Circ Res 64:753-763.
26. Kleiman RB and Houser SR (1988) Calcium currents in normal and hypertrophied isolated feline ventricular myocytes. Am J Physiol 255:H1434-H1442.
27. Kleiman RB and Houser SR (1989) Outward currents in normal and hypertrophied feline ventricular myocytes. Am J Physiol 256:H1450-H1461.
28. Kohya T, Kimura S, Myerberg RJ and Bassett AL (1988) Susceptibility of hypertrophied rat hearts to ventricular fibrillation during acute ischemia. J Mol Cell Cardiol 21:729-739.
29. Kohya T, Yokoshiki H, Toshe N, Kanno M, Nakaya H, Saito H and Kitabatake A (1995) Regression of left ventricular hypertrophy prevents ischemia-induced lethal arrhythmias: Beneficial effect of angiotensin II blockade. Circ Res 76:892-899.
30. + currents in nonfailing human hearts. Similarities between septal subendocardial and left subepicardial ventricular myocytes. Circulation 92:1174-1187.
31. Kowey PR, Friehling TD, Sewter J, Wu Y, Sokil A, Paul J and Nocella J (1991) Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade. Circulation 83:2067-2075.
32. Lerman BB, Burkoff D, Yue DT and Sagawa K (1985) Mechano-electrical feedback: Independent role of preload and contractility in modulation of canine ventricular excitability. J Clin Invest 76:1843-1850.
33. Lynch JJ Jr, Sanguinetti MC, Kimura S and Bassett AL (1992) Therapeutic potential of modulating potassium currents in the diseased myocardium. FASEB J 6:2952-2960.
34. McLenachan JM and Dargie HJ (1990) A review of rhythm disorders in cardiac hypertrophy. Am J Cardiol 65:42G-44G.
35. Montgomery DC (1991) Design and Analysis of Experiments. John Wiley & Sons, New York.
36. Mugelli A, Amerini S, Piazzesi G and Grottie A (1983) Barium-induced spontaneous activity in sheep cardiac Purkinje fibers. J Mol Cell Cardiol 15:697-712.
37. Myerburg RJ, Kassier KM and Castellanos A (1992) Sudden cardiac death. Structure, function, and time-dependence of risk. Circulation 85:suppl I;I2-I10.
38. Nabauer M, Beuckelmann DJ and Erdmann E (1993) Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73:386-394.
39. Nordin C, Siri F and Aronson SR (1989) Electrophysiologic characteristics of single myocytes isolated from hypertrophied guinea-pig hearts. J Mol Cell Cardiol 21: 729-739.
40. Rials SJ, Wu Y, Ford N, Pauletto FJ, Abramson SV, Rubin AM, Marinchak RA and Kowey PR (1995) Effect of left ventricular hypertrophy and its regression on ventricular electrophysiology and vulnerability to inducible arrhythmia in the feline heart. Circulation 91:426-430.
41. Schoen FJ, Lawrie GM and Titus JL (1984) Left ventricular cellular hypertrophy in pressure-and volume-overload valvular heart disease. Hum Path 15:860-865.
42. Segel LP, Ensunsa JL and Boyle WA III (1987) Prolonged support of working rabbit hearts using fluosal-43 or erythrocyte media. Am J Physiol 252:H349-H359.
43. Shibata EF, Drury T, Refsum H, Aldrete V and Giles W (1989) Contributions of a transient outward current to repolarization in human atrium. Am J Physiol 257:H1773-H1781.
44. Tomaselli GF, Beukelmann DJ, Calkins AG, Berger RD, Kessler PD, Lawrence JH, Kass D, Feldman AM and Marban E (1994) Sudden cardiac death in heart failure: The role of abnormal repolarization. Circulation 90:2534-2539.
45. Tomita F, Bassett AL, Myerburg RJ and Kimura S (1994) Diminished transient outward currents in rat hypertrophied ventricular myocytes. Circ Res 75:296-303.
46. Veldkamp MW, van Ginnekan ACG and Boumon LN (1993) Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circ Res 72:865-878.
47. Wang L, Chiamvimonvat N and Duff HJ (1993) Interaction between selected sodium and potassium channel blockers in guinea pig papillary muscle. J Pharmacol Exp Ther 264:1056-1062.
48. + channels in mouse heart. Circ Res 79:79-85.
49. Wettwer E, Amos GJ, Posival H and Ravens U (1994) Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75:473-482.
50. + current in ventricular myocytes from acromegalic rats. Am J Physiol 260:H935-H942.