An in vitro beating heart model for long-term assessment of experimental therapeutics

Cardiovascular Research

Volumn 81, Issue 2, 2009, Pages 253-259

  Habeler, Walter ^a   Pouillot, Séverine ^a   Plancheron, Alexandra ^a   Pucéat, Michel ^a   Peschanski, Marc ^a   Monville, Christelle ^a  

^a INSERM   (France)

Author keywords

Cell therapy; Heart slice cultures; Human embryonic stem cells

Indexed keywords

ADRENALIN;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYONIC STEM CELL; FETUS; GENE EXPRESSION; HEART BEAT; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MEMBRANE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL TRANSPLANTATION; TISSUE CULTURE; TISSUE SECTION;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CONNEXIN 43; EMBRYONIC STEM CELLS; EPINEPHRINE; HEART DISEASES; HUMANS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; TISSUE CULTURE TECHNIQUES;

EID: 58449087556     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn299     Document Type: Article

References (31)

1. Murry CE, Wiseman RW, Schwartz SM, Hauschka SD. Skeletal myoblast transplantation for repair of myocardial necrosis. J Clin Invest 1996;98:2512-2523.
2. Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 1998;4:929-933.
3. Ghostine S, Carrion C, Souza LC, Richard P, Bruneval P, Vilquin JT et al. Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction. Circulation 2002;106:I131- I136.
4. Hagège AA, Carrion C, Menasché P, Vilquin JT, Duboc D, Marolleau JP et al. Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy. Lancet 2003;361:491- 492.
5. Menasché P, Hagège AA, Vilquin JT, Desnos M, Abergel E, Pouzet B et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol 2003;41:1078-1083.
6. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol 2003;41:879-888.
7. Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci 2001;938:229-230.
8. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Hervé P et al. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 2003;108:II253-II258.
9. Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 2005;102:11474-11479.
10. Amado LC, Schuleri KH, Saliaris AP, Boyle AJ, Helm R, Oskouei B et al. Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapy. J Am Coll Cardiol 2006;48:2116-2124.
11. Laflamme MA, Gold J, Xu C, Hassanipour M, Rosler E, Police S et al. Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol 2005;167:663-671.
12. Kehat I, Gepstein A, Spira A, Itskovitz-Eldor J, Gepstein L. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ Res 2002;91:659-661.
13. He JQ, Ma Y, Lee Y, Thomson JA, Kamp TJ. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res 2003;93:32-39.
14. Tomescot A, Leschik J, Bellamy V, Dubois G, Messas E, Bruneval P et al. Differentiation in vivo of cardiac committed human embryonic stem cells in post-myocardial infracted rats. Stem Cells 2007;25:2200- 2205.
15. Menasché P. Stem cells for clinical use in cardiovascular medicine: current limitations and future perspectives. Thromb Haemost 2005;94:697-701.
16. Pillekamp F, Reppel M, Dinkelacker V, Duan Y, Jazmati N, Bloch W et al. Establishment and characterization of a mouse embryonic heart slice preparation. Cell Physiol Biochem 2005;16:127-132.
17. Pillekamp F, Reppel M, Brockmeier K, Hescheler J. Impulse propagation in late-stage embryonic and neonatal murine ventricular slices. J Electrocardiol 2006;39:425e1-425e4.
18. Pillekamp F, Reppel M, Rubenchyk O, Pfannkuche K, Matzkies M, Bloch W et al. Force measurements of human embryonic stem cell-derived cardiomyocytes in an in vitro transplantation model. Stem Cells 2007;25:174-180.
19. Gandolfi AJ, Brendel K, Fisher RL, Michaud JP. Use of tissue slices in chemical mixture toxicology and interspecies investigations. Toxicology 1995;105:285-290.
20. Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI et al. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med 2008;14:213-221.
21. Gahwiler BH. Slice cultures of cerebellar, hippocampal and hypothalamic tissue. Experientia 1984;40:235-243.
22. Stoppini L, Buchs PA, Muller D. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991;37:173-182.
23. Noraberg J, Poulsen FR, Blaabjerg M, Kristensen BW, Bonde C, Montero M et al. Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Curr Drug Target CNS Neurol Disord 2005;4:435-452.
24. de Boüard S, Christov C, Guillamo JS, Kassar-Duchossoy L, Palfi S, Leguerinel C et al. Invasion of human glioma biopsy specimens in cultures of rodent brain slices: a quantitative analysis. J Neurosurg 2002;97:169-176.
25. Oliveira R, Christov C, Guillamo JS, de Boüard S, Palfi S, Venance L et al. Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas. BMC Cell Biol 2005;6:1-17.
26. Gähwiler BH, Capogna M, Debanne D, McKinney RA, Thompson SM. Organotypic slice cultures: a technique has come of age. Trends Neurosci 1997;20:471-477.
27. Gähwiler BH. Organotypic monolayer cultures of nervous tissue. J Neurosci Methods 1981;4:329-342.
28. Matsushita S, Kurihara H, Watanabe M, Okada T, Sakai T, Amano A. Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. J Histochem Cytochem 2006;54:343-353.
29. Behfar A, Zingman LV, Hodgson DM, Rauzier JM, Kane GC, Terzic A et al. Stem cell differentiation requires a paracrine pathway in the heart. FASEB J 2002;16:1558-1566.
30. Puceat M. TGFbeta in the differentiation of embryonic stem cells. Cardiovasc Res 2007;74:256-261.
31. Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J 2007;21:1345-1357.