Synthesis and characterization of cisplatin-loaded, EGFR-targeted biopolymer and in vitro evaluation for targeted delivery

Journal of Biomedical Materials Research - Part A

Volumn 100 A, Issue 10, 2012, Pages 2839-2848

  Geng, Xu ^a   Ye, Haifeng ^b   Feng, Zhen ^a,c   Lao, Xun ^a   Zhang, Li ^a   Huang, Jing ^a   Wu, Zi Rong ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b ETH ZURICH   (Switzerland)

^c SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

cisplatin; maleimide functionalized biopolymer; N (maleimidohexanoyl) ethylenediamine; poly gamma L glutamic acid; targeted drug delivery

Indexed keywords

AMIDATION REACTION; ANTICANCER ACTIVITIES; ANTICANCER DRUG; AVERAGE SIZE; CANCER CELLS; CELLULAR UPTAKE; CIS-PLATIN; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTORS; ETHYLENE DIAMINE; FLOW CYTOMETRY ANALYSIS; FLUORESCENCE IMAGING; GLUTAMIC ACID; HUMAN HEPATOMA CELL LINES; IN-VITRO EVALUATION; PHYSIOLOGICAL SALINE; RELEASE PROFILES; RELEASE TIME; TARGETED CHEMOTHERAPY; TARGETED DELIVERY; TARGETED DRUG DELIVERY; THERAPEUTIC DRUGS;

AMINO ACIDS; CELL CULTURE; CHEMOTHERAPY; DISEASES; DRUG DELIVERY; PLATINUM; PLATINUM COMPOUNDS; SYNTHESIS (CHEMICAL); TUMORS;

BIOMOLECULES;

BIOPOLYMER; CISPLATIN; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR; N (MALEIMIDOHEXANOYL) ETHYLENEDIAMINE; UNCLASSIFIED DRUG;

AMIDATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; DRUG RELEASE; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA;

AMINO ACID SEQUENCE; ASPARTIC ACID; BIOPOLYMERS; CELL DEATH; CELL LINE, TUMOR; CISPLATIN; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALEIMIDES; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PARTICLE SIZE; PEPTIDES; POLYGLUTAMIC ACID; RECEPTOR, EPIDERMAL GROWTH FACTOR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84865616678     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34207     Document Type: Article

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