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Volumn 31, Issue 26, 2010, Pages 6859-6866

The effect of swelling and cationic character on gene transfection by pH-sensitive nanocarriers

Author keywords

[No Author keywords available]

Indexed keywords

2-HYDROXYETHYL METHACRYLATE; ATPASES; BAFILOMYCIN; DIMETHACRYLATES; DIMETHYLAMINOETHYL METHACRYLATES; DNA RELEASE; ENDOSOMAL PH; GENE TRANSFECTION; NANOCARRIERS; PH SENSITIVE; PLASMID DNA (PDNA); PLGA NANOPARTICLES; POLY(LACTIC-CO-GLYCOLIC ACID); POLYETHYLENEIMINE; TETRAETHYLENE GLYCOLS; TRIGGERED RELEASE; VOLUMETRIC SWELLING;

EID: 77954385063     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.04.048     Document Type: Article
Times cited : (38)

References (43)
  • 1
    • 14044272234 scopus 로고    scopus 로고
    • Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters)
    • Anderson D.G., Akinc A., Hossain N., Langer R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol Ther 2005, 11(3):426-434.
    • (2005) Mol Ther , vol.11 , Issue.3 , pp. 426-434
    • Anderson, D.G.1    Akinc, A.2    Hossain, N.3    Langer, R.4
  • 2
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine
    • Boussif O., Lezoualch F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92(16):7297-7301.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.16 , pp. 7297-7301
    • Boussif, O.1    Lezoualch, F.2    Zanta, M.A.3    Mergny, M.D.4    Scherman, D.5    Demeneix, B.6
  • 3
    • 4344594697 scopus 로고    scopus 로고
    • Enhancement of transfection efficiency through rapid and noncovalent post-PEGylation of poly(dimethylaminoethyl methacrylate)/DNA complexes
    • Pirotton S., Muller C., Pantoustier N., Botteman F., Collinet B., Grandfils C., et al. Enhancement of transfection efficiency through rapid and noncovalent post-PEGylation of poly(dimethylaminoethyl methacrylate)/DNA complexes. Pharm Res 2004, 21(8):1471-1479.
    • (2004) Pharm Res , vol.21 , Issue.8 , pp. 1471-1479
    • Pirotton, S.1    Muller, C.2    Pantoustier, N.3    Botteman, F.4    Collinet, B.5    Grandfils, C.6
  • 5
    • 0035860723 scopus 로고    scopus 로고
    • Biological properties of poly-L-lysine-DNA complexes generated by cooperative binding of the polycation
    • Liu G., Molas M., Grossmann G.A., Pasumarthy M., Perales J.C., Cooper M.J., et al. Biological properties of poly-L-lysine-DNA complexes generated by cooperative binding of the polycation. J Biol Chem 2001, 276(37):34379-34387.
    • (2001) J Biol Chem , vol.276 , Issue.37 , pp. 34379-34387
    • Liu, G.1    Molas, M.2    Grossmann, G.A.3    Pasumarthy, M.4    Perales, J.C.5    Cooper, M.J.6
  • 6
    • 13244272430 scopus 로고    scopus 로고
    • Calcium-alginate nanoparticles formed by reverse microemulsion as gene carriers
    • You J.O., Peng C.A. Calcium-alginate nanoparticles formed by reverse microemulsion as gene carriers. Macromol Symp 2004, 219(1):147-153.
    • (2004) Macromol Symp , vol.219 , Issue.1 , pp. 147-153
    • You, J.O.1    Peng, C.A.2
  • 7
    • 33847099637 scopus 로고    scopus 로고
    • Lipid-based nanoparticles for nucleic acid delivery
    • Li W.J., Szoka F.C. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res 2007, 24(3):438-449.
    • (2007) Pharm Res , vol.24 , Issue.3 , pp. 438-449
    • Li, W.J.1    Szoka, F.C.2
  • 8
    • 0030005461 scopus 로고    scopus 로고
    • PH-sensitive, cationic liposomes: a new synthetic virus-like vector
    • Budker V., Gurevich V., Hagstrom J.E., Bortzov F., Wolff J.A. pH-sensitive, cationic liposomes: a new synthetic virus-like vector. Nat Biotechnol 1996, 14(6):760-764.
    • (1996) Nat Biotechnol , vol.14 , Issue.6 , pp. 760-764
    • Budker, V.1    Gurevich, V.2    Hagstrom, J.E.3    Bortzov, F.4    Wolff, J.A.5
  • 9
    • 33646830005 scopus 로고
    • Ion motive ATPases. I. Ubiquity, properties, and significance to cell function
    • Pedersen P.L., Carafoli E. Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem Sci 1987, 12:146-150.
    • (1987) Trends Biochem Sci , vol.12 , pp. 146-150
    • Pedersen, P.L.1    Carafoli, E.2
  • 10
    • 0031743946 scopus 로고    scopus 로고
    • Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection
    • Bayer N., Schober D., Prchla E., Murphy R.F., Blaas D., Fuchs R. Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection. J Virol 1998, 72(12):9645-9655.
    • (1998) J Virol , vol.72 , Issue.12 , pp. 9645-9655
    • Bayer, N.1    Schober, D.2    Prchla, E.3    Murphy, R.F.4    Blaas, D.5    Fuchs, R.6
  • 11
    • 0040117958 scopus 로고    scopus 로고
    • Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases
    • Drose S., Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol 1997, 200(1):1-8.
    • (1997) J Exp Biol , vol.200 , Issue.1 , pp. 1-8
    • Drose, S.1    Altendorf, K.2
  • 12
    • 0035286969 scopus 로고    scopus 로고
    • Polyethylenimine-mediated gene delivery: a mechanistic study
    • Kichler A., Leborgne C., Coeytaux E., Danos O. Polyethylenimine-mediated gene delivery: a mechanistic study. J Gene Med 2001, 3(2):135-144.
    • (2001) J Gene Med , vol.3 , Issue.2 , pp. 135-144
    • Kichler, A.1    Leborgne, C.2    Coeytaux, E.3    Danos, O.4
  • 13
    • 0029865912 scopus 로고    scopus 로고
    • Enhanced cellular uptake of oligonucleotides by EGF receptor-mediated endocytosis in A549 cells
    • Deshpande D., ToledoVelasquez D., Thakkar D., Liang W.W., Rojanasakul Y. Enhanced cellular uptake of oligonucleotides by EGF receptor-mediated endocytosis in A549 cells. Pharm Res 1996, 13(1):57-61.
    • (1996) Pharm Res , vol.13 , Issue.1 , pp. 57-61
    • Deshpande, D.1    ToledoVelasquez, D.2    Thakkar, D.3    Liang, W.W.4    Rojanasakul, Y.5
  • 14
    • 0347685883 scopus 로고    scopus 로고
    • Role of endosomes in gene transfection mediated by photochemical internalisation (PCI)
    • Prasmickaite L., Hogset A., Tjelle T.E., Olsen V.M., Berg K. Role of endosomes in gene transfection mediated by photochemical internalisation (PCI). J Gene Med 2000, 2(6):477-488.
    • (2000) J Gene Med , vol.2 , Issue.6 , pp. 477-488
    • Prasmickaite, L.1    Hogset, A.2    Tjelle, T.E.3    Olsen, V.M.4    Berg, K.5
  • 15
    • 11844290850 scopus 로고    scopus 로고
    • Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer
    • Boeckle S., von Gersdorff K., van der Piepen S., Culmsee C., Wagner E., Ogris M. Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J Gene Med 2004, 6(10):1102-1111.
    • (2004) J Gene Med , vol.6 , Issue.10 , pp. 1102-1111
    • Boeckle, S.1    von Gersdorff, K.2    van der Piepen, S.3    Culmsee, C.4    Wagner, E.5    Ogris, M.6
  • 16
    • 0029744235 scopus 로고    scopus 로고
    • Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles
    • Cherng J.Y., van de Wetering P., Talsma H., Crommelin D.J.A., Hennink W.E. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm Res 1996, 13(7):1038-1042.
    • (1996) Pharm Res , vol.13 , Issue.7 , pp. 1038-1042
    • Cherng, J.Y.1    van de Wetering, P.2    Talsma, H.3    Crommelin, D.J.A.4    Hennink, W.E.5
  • 17
    • 0033166988 scopus 로고    scopus 로고
    • Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery
    • van de Wetering P., Moret E.E., Schuurmans-Nieuwenbroek N.M.E., van Steenbergen M.J., Hennink W.E. Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery. Bioconjug Chem 1999, 10(4):589-597.
    • (1999) Bioconjug Chem , vol.10 , Issue.4 , pp. 589-597
    • van de Wetering, P.1    Moret, E.E.2    Schuurmans-Nieuwenbroek, N.M.E.3    van Steenbergen, M.J.4    Hennink, W.E.5
  • 18
    • 0037954557 scopus 로고    scopus 로고
    • Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles
    • Jones R.A., Cheung C.Y., Black F.E., Zia J.K., Stayton P.S., Hoffman A.S., et al. Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles. Biochem J 2003, 372:65-75.
    • (2003) Biochem J , vol.372 , pp. 65-75
    • Jones, R.A.1    Cheung, C.Y.2    Black, F.E.3    Zia, J.K.4    Stayton, P.S.5    Hoffman, A.S.6
  • 19
    • 0026655684 scopus 로고
    • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle
    • Wagner E., Plank C., Zatloukal K., Cotten M., Birnstiel M.L. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc Natl Acad Sci U S A 1992, 89(17):7934-7938.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.17 , pp. 7934-7938
    • Wagner, E.1    Plank, C.2    Zatloukal, K.3    Cotten, M.4    Birnstiel, M.L.5
  • 20
    • 0033676359 scopus 로고    scopus 로고
    • Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles
    • Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., et al. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther 2000, 7(22):1896-1905.
    • (2000) Gene Ther , vol.7 , Issue.22 , pp. 1896-1905
    • Cohen, H.1    Levy, R.J.2    Gao, J.3    Fishbein, I.4    Kousaev, V.5    Sosnowski, S.6
  • 21
    • 0032949618 scopus 로고    scopus 로고
    • PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization
    • Ando S., Putnam D., Pack D.W., Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J Pharm Sci 1999, 88(1):126-130.
    • (1999) J Pharm Sci , vol.88 , Issue.1 , pp. 126-130
    • Ando, S.1    Putnam, D.2    Pack, D.W.3    Langer, R.4
  • 22
    • 0036077937 scopus 로고    scopus 로고
    • Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system
    • Petersen H., Fechner P.M., Martin A.L., Kunath K., Stolnik S., Roberts C.J., et al. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug Chem 2002, 13(4):845-854.
    • (2002) Bioconjug Chem , vol.13 , Issue.4 , pp. 845-854
    • Petersen, H.1    Fechner, P.M.2    Martin, A.L.3    Kunath, K.4    Stolnik, S.5    Roberts, C.J.6
  • 23
    • 0031709640 scopus 로고    scopus 로고
    • Arterial uptake of biodegradable nanoparticles: effect of surface modifications
    • Labhasetwar V., Song C.X., Humphrey W., Shebuski R., Levy R.J. Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J Pharm Sci 1998, 87(10):1229-1234.
    • (1998) J Pharm Sci , vol.87 , Issue.10 , pp. 1229-1234
    • Labhasetwar, V.1    Song, C.X.2    Humphrey, W.3    Shebuski, R.4    Levy, R.J.5
  • 24
    • 71949126830 scopus 로고    scopus 로고
    • Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer
    • You J.O., Auguste D.T. Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer. Nano Lett 2009, 9(12):4467-4473.
    • (2009) Nano Lett , vol.9 , Issue.12 , pp. 4467-4473
    • You, J.O.1    Auguste, D.T.2
  • 25
    • 0031551011 scopus 로고    scopus 로고
    • Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection
    • Stegmann T., Legendre J.Y. Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection. Biochim Biophys Acta 1997, 1325(1):71-79.
    • (1997) Biochim Biophys Acta , vol.1325 , Issue.1 , pp. 71-79
    • Stegmann, T.1    Legendre, J.Y.2
  • 26
    • 0033084717 scopus 로고    scopus 로고
    • Polycation-based DNA complexes for tumor-targeted gene delivery in vivo
    • Kircheis R., Schuller S., Brunner S., Ogris M., Heider K.H., Zauner W., et al. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J Gene Med 1999, 1(2):111-120.
    • (1999) J Gene Med , vol.1 , Issue.2 , pp. 111-120
    • Kircheis, R.1    Schuller, S.2    Brunner, S.3    Ogris, M.4    Heider, K.H.5    Zauner, W.6
  • 27
    • 39649112402 scopus 로고    scopus 로고
    • Feedback-regulated paclitaxel delivery based on poly(N, N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticles
    • You J.O., Auguste D.T. Feedback-regulated paclitaxel delivery based on poly(N, N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticles. Biomaterials 2008, 29(12):1950-1957.
    • (2008) Biomaterials , vol.29 , Issue.12 , pp. 1950-1957
    • You, J.O.1    Auguste, D.T.2
  • 28
    • 1242292220 scopus 로고    scopus 로고
    • Partial acetylation of polyethylenimine enhances in vitro gene delivery
    • Forrest M.L., Meister G.E., Koerber J.T., Pack D.W. Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharm Res 2004, 21(2):365-371.
    • (2004) Pharm Res , vol.21 , Issue.2 , pp. 365-371
    • Forrest, M.L.1    Meister, G.E.2    Koerber, J.T.3    Pack, D.W.4
  • 29
    • 0029869843 scopus 로고    scopus 로고
    • An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
    • Aniento F., Gu F., Parton R.G., Gruenberg J. An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol 1996, 133(1):29-41.
    • (1996) J Cell Biol , vol.133 , Issue.1 , pp. 29-41
    • Aniento, F.1    Gu, F.2    Parton, R.G.3    Gruenberg, J.4
  • 30
    • 0027203163 scopus 로고
    • The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected
    • Presley J.F., Mayor S., Dunn K.W., Johnson L.S., Mcgraw T.E., Maxfield F.R. The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected. J Cell Biol 1993, 122(6):1231-1241.
    • (1993) J Cell Biol , vol.122 , Issue.6 , pp. 1231-1241
    • Presley, J.F.1    Mayor, S.2    Dunn, K.W.3    Johnson, L.S.4    Mcgraw, T.E.5    Maxfield, F.R.6
  • 31
    • 28844460780 scopus 로고    scopus 로고
    • Intracellular trafficking of nonviral vectors
    • Medina-Kauwe L.K., Xie J., Hamm-Alvarez S. Intracellular trafficking of nonviral vectors. Gene Ther 2005, 12(24):1734-1751.
    • (2005) Gene Ther , vol.12 , Issue.24 , pp. 1734-1751
    • Medina-Kauwe, L.K.1    Xie, J.2    Hamm-Alvarez, S.3
  • 32
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • Haensler J., Szoka F.C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 1993, 4(5):372-379.
    • (1993) Bioconjug Chem , vol.4 , Issue.5 , pp. 372-379
    • Haensler, J.1    Szoka, F.C.2
  • 33
    • 0029799791 scopus 로고    scopus 로고
    • A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine
    • Abdallah B., Hassan A., Benoist C., Goula D., Behr J.P., Demeneix B.A. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Gene Ther 1996, 7(16):1947-1954.
    • (1996) Gene Ther , vol.7 , Issue.16 , pp. 1947-1954
    • Abdallah, B.1    Hassan, A.2    Benoist, C.3    Goula, D.4    Behr, J.P.5    Demeneix, B.A.6
  • 34
    • 1642588217 scopus 로고    scopus 로고
    • Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multiblock copolymers for nonviral gene delivery
    • Bikram M., Ahn C.H., Chae S.Y., Lee M.Y., Yockman J.W., Kim S.W. Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multiblock copolymers for nonviral gene delivery. Macromolecules 2004, 37(5):1903-1916.
    • (2004) Macromolecules , vol.37 , Issue.5 , pp. 1903-1916
    • Bikram, M.1    Ahn, C.H.2    Chae, S.Y.3    Lee, M.Y.4    Yockman, J.W.5    Kim, S.W.6
  • 35
    • 0037026269 scopus 로고    scopus 로고
    • Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
    • Prabha S., Zhou W.Z., Panyam J., Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int J Pharm 2002, 244(1-2):105-115.
    • (2002) Int J Pharm , vol.244 , Issue.1-2 , pp. 105-115
    • Prabha, S.1    Zhou, W.Z.2    Panyam, J.3    Labhasetwar, V.4
  • 36
    • 13844262865 scopus 로고    scopus 로고
    • Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating
    • MacKay J.A., Deen D.F., Szoka F.C. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res 2005, 1035(2):139-153.
    • (2005) Brain Res , vol.1035 , Issue.2 , pp. 139-153
    • MacKay, J.A.1    Deen, D.F.2    Szoka, F.C.3
  • 37
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis
    • Rejman J., Oberle V., Zuhorn I.S., Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem J 2004, 377:159-169.
    • (2004) Biochem J , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 38
    • 39749178290 scopus 로고    scopus 로고
    • Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells
    • Harush-Frenkel O., Rozentur E., Benita S., Altschuler Y. Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells. Biomacromolecules 2008, 9(2):435-443.
    • (2008) Biomacromolecules , vol.9 , Issue.2 , pp. 435-443
    • Harush-Frenkel, O.1    Rozentur, E.2    Benita, S.3    Altschuler, Y.4
  • 39
    • 67349092492 scopus 로고    scopus 로고
    • Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells
    • Gabrielson N.P., Pack D.W. Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells. J Control Release 2009, 136(1):54-61.
    • (2009) J Control Release , vol.136 , Issue.1 , pp. 54-61
    • Gabrielson, N.P.1    Pack, D.W.2
  • 40
    • 20144373766 scopus 로고    scopus 로고
    • Non-viral gene delivery regulated by stiffness of cell adhesion substrates
    • Kong H.J., Liu J.D., Riddle K., Matsumoto T., Leach K., Mooney D.J. Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat Mater 2005, 4(6):460-464.
    • (2005) Nat Mater , vol.4 , Issue.6 , pp. 460-464
    • Kong, H.J.1    Liu, J.D.2    Riddle, K.3    Matsumoto, T.4    Leach, K.5    Mooney, D.J.6
  • 41
    • 42049096359 scopus 로고    scopus 로고
    • A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery
    • Parsa S., Wang Y., Fuller J., Langer R., Pfeifer B.A. A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery. Pharm Res 2008, 25(5):1202-1208.
    • (2008) Pharm Res , vol.25 , Issue.5 , pp. 1202-1208
    • Parsa, S.1    Wang, Y.2    Fuller, J.3    Langer, R.4    Pfeifer, B.A.5
  • 42
    • 34147101146 scopus 로고    scopus 로고
    • Poly(L-lactide-co-glycolide) nanospheres conjugated with a nuclear localization signal for delivery of plasmid DNA
    • Jeon O., Lim H.W., Lee M., Song S.J., Kim B.S. Poly(L-lactide-co-glycolide) nanospheres conjugated with a nuclear localization signal for delivery of plasmid DNA. J Drug Target 2007, 15(3):190-198.
    • (2007) J Drug Target , vol.15 , Issue.3 , pp. 190-198
    • Jeon, O.1    Lim, H.W.2    Lee, M.3    Song, S.J.4    Kim, B.S.5
  • 43
    • 0032921913 scopus 로고    scopus 로고
    • Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery
    • Wang D.Q., Robinson D.R., Kwon G.S., Samuel J. Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J Control Release 1999, 57(1):9-18.
    • (1999) J Control Release , vol.57 , Issue.1 , pp. 9-18
    • Wang, D.Q.1    Robinson, D.R.2    Kwon, G.S.3    Samuel, J.4


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