Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 23236-23245

  Sato, Yoshifumi ^a   Hatta, Mitsutoki ^a   Karim, Md Fazlul ^a   Sawa, Tomohiro ^a,b   Wei, Fan Yan ^a   Sato, Shoki ^a   Magnuson, Mark A ^c   Gonzalez, Frank J ^d   Tomizawa, Kazuhito ^a   Akaike, Takaaki ^a   Yoshizawa, Tatsuya ^a   Yamagata, Kazuya ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; CELL FUNCTIONS; CELL SUSCEPTIBILITY; ENDOPLASMIC RETICULUM; ER STRESS; MATURITY-ONSET DIABETES OF THE YOUNG; MIN6 CELLS; NUCLEAR RECEPTORS; OVER-EXPRESSION; PROMOTER ACTIVITIES; STRESS-INDUCED; TARGET GENES;

CELL DEATH; CELL MEMBRANES; GLUCOSE; TRANSCRIPTION FACTORS;

GENES;

ANKYRIN; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN CONTAINING 4B PROTEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GUANYLATE CYCLASE; GUANYLATE CYCLASE 2C; HEPATOCYTE NUCLEAR FACTOR 4; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL FUNCTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GLUCOSE METABOLISM; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION PROFILING; HEAT-SHOCK PROTEINS; INSULIN-SECRETING CELLS; INSULINOMA; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; PROTEOMICS; TRANSCRIPTIONAL ACTIVATION;

EID: 84863320962     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.368779     Document Type: Article

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