Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis

Journal of Molecular and Cellular Cardiology

Volumn 53, Issue 4, 2012, Pages 459-468

  Mohamed, Belal A ^a   Barakat, Amal Z ^a   Zimmermann, Wolfram Hubertus ^a   Bittner, Reginald E ^b   Mühlfeld, Christian ^c   Hünlich, Mark ^a   Engel, Wolfgang ^a   Maier, Lars S ^a   Adham, Ibrahim M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Fibrosis; HSPA4; Hypertrophy; Polyubiquitination; Pressure overload

Indexed keywords

CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CHAPERONE; GLYCOPROTEIN GP 130; HEAT SHOCK PROTEIN 110; ION CHANNEL; MUSCLE PROTEIN; MUSCLE SPECIFIC CONTRACTILE PROTEIN; PROTEIN HSPA4; STAT3 PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY WEIGHT; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; GENE; GENE DISRUPTION; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENE TARGETING; HEART CONTRACTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HEART WEIGHT; HSPA4 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; MARKER GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOTTING; PROTEIN DEFECT; PROTEIN FOLDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; AORTIC VALVE STENOSIS; CALCINEURIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMEGALY; CELLS, CULTURED; CONTRACTILE PROTEINS; CYTOKINE RECEPTOR GP130; FIBROSIS; HOMEOSTASIS; HSP110 HEAT-SHOCK PROTEINS; HUMANS; ION CHANNELS; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; MYOCARDIUM; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STRESS, PHYSIOLOGICAL; UBIQUITINATED PROTEINS; VENTRICULAR REMODELING;

MURINAE; MUS;

EID: 84865547689     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.07.014     Document Type: Article

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