Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts

Journal of Applied Physiology

Volumn 102, Issue 5, 2007, Pages 2024-2032

  Kumbar, Deepa H ^a   VanBergen, Andrew ^a   Ocampo, Catherina ^a   Muangmingsuk, Sunthorn ^a   Griffin, Andrew J ^a,b   Gupta, Madhu ^a,b  

^a ADVOCATE CHILDREN S HOSPITAL   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiotensin II; Cardiac remodeling; Extracellular signal regulated kinase; Type 1 collagen

Indexed keywords

ANGIOTENSIN II; COLLAGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN DOC 2; TISSUE PLASMINOGEN ACTIVATOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FIBROBLAST; FIBROBLAST CULTURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HEART VENTRICLE VOLUME; HEMODYNAMICS; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPRAGUE DAWLEY RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; ARTERIOVENOUS SHUNT, SURGICAL; CARDIOMEGALY; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FLAVONOIDS; GENE EXPRESSION; LIGATION; MYOCYTES, CARDIAC; PHORBOL ESTERS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; VENTRICULAR REMODELING;

EID: 34247847664     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00924.2006     Document Type: Article

References (40)

1. Albersten HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R. Sequence, genomic structure and chromosomal assignment of human DOC-2. Genomics 33: 207-213, 1996.
2. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 56: 127-155, 2001.
3. Badenhorst D, Maseko M, Tsotetsi OJ, Naidoo A, Brooksband R, Norton GR, Wodiwiss AJ. Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodeling in hypertension in rats. Cardiovasc Res 57: 632-641, 2003.
4. Baicu CF, Stroud JD, Livesay VA, Hapke E, Holder J, Spinale FG, Zile MR. Changes in extracellular collagen matrix alter myocardial systolic performance. Am J Physiol Heart Circ Physiol 284: H122-H132, 2003.
5. Bishop JE, Lindahl G. Regulation of cardiovascular collagen synthesis by mechanical load. Cardiovasc Res 42: 27-44, 1999.
6. Bouzegrhane F, Thibault G. Is angiotensin II a proliferative factor of cardiac fibroblasts? Cardiovasc Res 53: 304-312, 2002.
7. Chandrashekar DH, Ocampo C, Arcilla RA, Gupta M. Altered expression of DOC-2/Dab2 in volume load hypertrophy identified by high density oligonucleotide microarray. Pediatr Res 53: 200, 2003.
8. Corda S, Samuel JL, Rappaport. Extracellular matrix and growth factors during heart growth. Heart Failure Rev 5: 119-130, 2000.
9. Dolgilevich SM, Siri FM, Atlas SA, Eng C. Changes in collagenase and collagen gene expression after induction of aortocaval fistula in rats. Am J Physiol Heart Circ Physiol 281: H207-H214, 2001.
10. Downward J. Control of Ras activation. Cancer Surv 27: 87-100, 1996.
11. Gao XM, Kiriazir H, Moore XL, Feng XH, Sheppard K, Dart A, Du XJ. Regression of pressure overload-induced left ventricular hypertrophy in mice. Am J Physiol Heart Circ Physiol 288: H2702-H2707, 2005.
12. Garcia R, Diebold S. Simple, rapid and effective method of producing aorto caval shunt in rats. CardiovascRes 24: 430-432, 1990.
13. Gupta MP, Gupta M, Stewart A, Zak R. Activation of alpha myosin heavy chain gene expression by cAMP in cultured fetal rat heart myocytes. Biochem Biophys Res Commun 174: 1196-1203, 1991.
14. He J, Xu J, Xu XX, Hall RA. Cell cycle-dependent phosphorylation of disabled-2 by cdc2. Oncogene 22: 4524-4530, 2003.
15. Heymans S, Schroen B, Vermeersh P, Milting H, Gao F, Kassner A, Gillijns H, Herijgers P, Flameng W, Carmeliet P, Van de Werf F, Pinto YM, Janssens S. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Circulation 112: 1136-1144, 2005.
16. Hocevar BA, Smine A, Xu XX, Howe PH. The adaptor molecule disabled-2 links the transforming growth factor β-receptors to the Smad pathway. EMBO J 20: 2789-2801, 2001.
17. Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J 22: 3084-3094, 2003.
18. Huang CL, Liao CL, Stern A, Hsieh JT, Hsu HL, Tseng CP. Dab-2 is a negative regulator of integrin mediated fibrinogen adhesion and cell signaling. J Biol Chem 279: 42279-42289, 2004.
19. Khan R, Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-β in cardiomyopathy, valvular disease and arrhythmia. Immunology 118: 10-24, 2006.
20. Koshy SK, Reddy HK, Shukla HH. Collagen cross-linking: new dimension to cardiac remodeling. Cardiovasc Res 57: 594-598, 2003.
21. Manabe I, Shindo T, Nagai R. Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res 91: 1103-1113, 2002.
22. Mok SC, Wong KK, Chan RKW, Lau CCC, Tsao SW, Knapp RC, Berkowitz RS. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol 52: 247-252, 1994.
23. Ocampo C, Ingram P, Ilbawi M, Arcilla R, Gupta M. Revisiting the surgical creation of volume load by aorto-caval shunt in rats. Mol Cell Biochem 251: 139-143, 2003.
24. 1(I) gene expression in cardiac fibroblasts. Cardiovasc Res 61: 736-744, 2004.
25. Pawson T, Scott JD. Signaling through scaffold, anchoring, and adaptor proteins. Science 278: 2075-2080, 1997.
26. Sadoshima J, Izumo S. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J 15: 775-787, 1996.
27. Stewart AFR, Rokosh G, Bailey BA, Karns LR, Chang KC, Long CS, Kariya K, Simpson PC. Cloning of the rat -1c-adrenergic receptors from cardiac myocytes; α-1c, α-1B and -α1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Circ Res 75: 796-802, 1994.
28. Sugden PH, Clerk A. Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists. Trends Cardiovasc Med 10: 1-8, 2000.
29. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev 79: 215-262, 1999.
30. Takeishi T, Huang Q, Abe J, Glassman M, Che W, Lee JD, Kawakatsu H, Lawrence EG, Hoit BD, Berk BC, Walsh RA. Src and multiple MAPK activation in cardiac hypertrophy and congestive heart failure under chronic pressure overload. J Mol Cell Cardiol 33: 1637-1648, 2001.
31. Thorburn A, Thorburn J, Chen SY, Powers S, Shubeita HE, Feramisco JR, Chien KR. Hras dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem 268: 2244-2249, 1993.
32. Tseng C, Ely BD, Li Y, Pong RC, Hsieh JT. Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Endocrinology 139: 3542-3553, 1998.
33. Tseng C, Ely BD, Pong R, Wand Z, Zhou J, Hsieh J. The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. J Biol Chem 274: 31981-31986, 1999.
34. Tyagi SC, Kumar S, Voelker DJ, Reddy HK, Janicki JS, Curtis JJ. Differential gene expression of extracellular matrix components in dilated cardiomyopathy. J Cell Biochem 63: 185-198, 1996.
35. Villarreal FJ, Kim NN. Regulation of myocardial extracellular matrix components by mechanical and chemical growth factors. Cardiovasc Pathol 7: 145-151, 1998.
36. Wittinghofer F. Ras signaling: caught in the act of the switch-on. Nature 394: 317-320, 1998.
37. Xu XX, Yang W, Jackowski S, Rock CO. Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem 270: 14184-14191, 1995.
38. Xu XX, Yi T, Tang B, Lambeth JD. Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene 16: 1561-1569, 1998.
39. Zhang S, Weinheimer C, Courtois M, Kovacs A, Zhang CE, Cheng AM, Wang Y, Muslin AJ. The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest 111: 833-841, 2003.
40. Zhou J, Hsieh JT. The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem 276: 27793-27798, 2001.