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Volumn 13, Issue 3, 2012, Pages 281-293

Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: Function, regulation, and context dependency

Author keywords

BHLH; Cochlea; Hair cells; Math1; Organ of Corti; Transcription factor

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ATOH1; UNCLASSIFIED DRUG;

EID: 84865516574     PISSN: 15253961     EISSN: 14387573     Source Type: Journal    
DOI: 10.1007/s10162-012-0317-4     Document Type: Article
Times cited : (88)

References (87)
  • 1
    • 77749322192 scopus 로고    scopus 로고
    • The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding
    • AGUADO-LLERA D, GOORMAGHTIGH E, DE GEEST N, QUAN XJ, PRIETO A, HASSAN BA, GOMEZ J, NEIRA JL (2010) The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. Biochemistry 49:1577-1589
    • (2010) Biochemistry , vol.49 , pp. 1577-1589
    • Aguado-Llera, D.1    Goormaghtigh, E.2    De Geest, N.3    Quan, X.J.4    Prieto, A.5    Hassan, B.A.6    Gomez, J.7    Neira, J.L.8
  • 2
    • 0028903796 scopus 로고
    • A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system
    • AKAZAWA C, ISHIBASHI M, SHIMIZU C, NAKANISHI S, KAGEYAMA R (1995) A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem 270:8730-8738
    • (1995) J Biol Chem , vol.270 , pp. 8730-8738
    • Akazawa, C.1    Ishibashi, M.2    Shimizu, C.3    Nakanishi, S.4    Kageyama, R.5
  • 3
    • 0033363492 scopus 로고    scopus 로고
    • Generation of cerebellar granule neurons in vivo by transplantation of BMPtreated neural progenitor cells
    • ALDER J, LEE KJ, JESSELL TM, HATTEN ME (1999) Generation of cerebellar granule neurons in vivo by transplantation of BMPtreated neural progenitor cells. Nat Neurosci 2:535-540
    • (1999) Nat Neurosci , vol.2 , pp. 535-540
    • Alder, J.1    Lee, K.J.2    Jessell, T.M.3    Hatten, M.E.4
  • 5
    • 77954380632 scopus 로고    scopus 로고
    • Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells
    • AYRAULT O, ZHAO H, ZINDY F, QU C, SHERR CJ, ROUSSEL MF (2010) Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res 70:5618-5627
    • (2010) Cancer Res , vol.70 , pp. 5618-5627
    • Ayrault, O.1    Zhao, H.2    Zindy, F.3    U, C.Q.4    Sherr, C.J.5    Roussel, M.F.6
  • 10
    • 33751404918 scopus 로고    scopus 로고
    • Neurogenin 3 and the enteroendocrine ell lineage in the adult mouse small intestinal epithelium
    • BJERKNES M, CHENG H (2006) Neurogenin 3 and the enteroendocrine ell lineage in the adult mouse small intestinal epithelium. ev Biol 300:722-735
    • (2006) Ev Biol , vol.300 , pp. 722-735
    • Bjerknes, M.1    Cheng, H.2
  • 11
    • 61349088047 scopus 로고    scopus 로고
    • The atonal proneural transcription factor links differentiation nd tumor formation in Drosophila
    • BOSSUYT W, DE GEEST N, AERTS S, LEENAERTS I, MARYNEN P, HASSAN BA (2009A) The atonal proneural transcription factor links differentiation nd tumor formation in Drosophila. PLoS Biol 7:e40
    • (2009) PLoS Biol , vol.7
    • Bossuyt, W.1    De Geest, N.2    Aerts, S.3    Leenaerts, I.4    Marynen, P.5    Hassan, B.6
  • 14
    • 0024052237 scopus 로고
    • The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    • CAUDY M, GRELL EH, DAMBLY-CHAUDIERE C, GHYSEN A, JAN LY, JAN YN (1988) The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev 2:843-852
    • (1988) Genes Dev , vol.2 , pp. 843-852
    • Caudy, M.1    Grell, E.H.2    Dambly-Chaudiere, C.3    Ghysen, A.4    Jan, L.Y.5    Jan, Y.N.6
  • 15
    • 0036337481 scopus 로고    scopus 로고
    • The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    • CHEN P, JOHNSON JE, ZOGHBI HY, SEGIL N (2002) The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell fate determination. Development 129:2495-2505
    • (2002) Development , vol.129 , pp. 2495-2505
    • Chen, P.1    Johnson, J.E.2    Zoghbi, H.Y.3    Segil, N.4
  • 16
    • 0029822418 scopus 로고    scopus 로고
    • Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes
    • CHIEN CT, HSIAO CD, JAN LY, JAN YN (1996) Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes. Proc Natl Acad Sci 93:13239-13244
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 13239-13244
    • Chien, C.T.1    Hsiao, C.D.2    Jan, L.Y.3    Jan, Y.N.4
  • 18
    • 0023918917 scopus 로고
    • Regeneration of sensory hair cells after acoustic trauma
    • CORWIN JT, COTANCHE DA (1988) Regeneration of sensory hair cells after acoustic trauma. Science 240:1772-1774
    • (1988) Science , vol.240 , pp. 1772-1774
    • Corwin, J.T.1    Cotanche, D.A.2
  • 21
    • 0000854910 scopus 로고
    • Independent subpatterns of sense organs require independent genes of the Aschaete-Scute complex (ASC) in Drosophila larvae
    • DAMBLY-CHAUDIERE C, GHYSEN A (1987) Independent subpatterns of sense organs require independent genes of the Aschaete-Scute complex (ASC) in Drosophila larvae. Genes Dev 1:297-306
    • (1987) Genes Dev , vol.1 , pp. 297-306
    • Dambly-Chaudiere, C.1    Ghysen, A.2
  • 22
    • 77951222415 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium
    • D'ANGELO A, BLUTEAU O, GARCIA-GONZALEZ MA, GRESH L, DOYEN A, GARBAY S, ROBINE S, PONTOGLIO M (2010) Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development 137:1573-1582
    • (2010) Development , vol.137 , pp. 1573-1582
    • D'Angelo, A.1    Bluteau, O.2    Garcia-Gonzalez, M.A.3    Gresh, L.4    Doyen, A.5    Garbay, S.6    Robine, S.7    Pontoglio, M.8
  • 23
    • 0034463801 scopus 로고    scopus 로고
    • The period E-box is sufficient to drive circadian oscillation of transcription in vivo
    • DARLINGTON TK, LYONS LC, HARDIN PE, KAY SA (2000) The period E-box is sufficient to drive circadian oscillation of transcription in vivo. J Biol Rhythms 15:462-471
    • (2000) J Biol Rhythms , vol.15 , pp. 462-471
    • Darlington, T.K.1    Lyons, L.C.2    Hardin, P.E.3    Kay, S.A.4
  • 24
    • 34247578657 scopus 로고    scopus 로고
    • Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric ice
    • DU X, JENSEN P, GOLDOWITZ D, HAMRE K (2007) Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric ice. Dev Biol 305:430-438
    • (2007) Dev Biol , vol.305 , pp. 430-438
    • U, X.D.1    Jensen, P.2    Goldowitz, D.3    Hamre, K.4
  • 26
  • 27
    • 34848860827 scopus 로고    scopus 로고
    • The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors
    • FLORA A, GARCIA JJ, THALLER C, ZOGHBI HY (2007) The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proc Natl Acad Sci 104:15382-15387
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 15382-15387
    • Flora, A.1    Garcia, J.J.2    Thaller, C.3    Zoghbi, H.Y.4
  • 28
    • 71549138077 scopus 로고    scopus 로고
    • Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma
    • FLORA A, KLISCH TJ, SCHUSTER G, ZOGHBI HY (2009) Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326:1424-1427
    • (2009) Science , vol.326 , pp. 1424-1427
    • Flora, A.1    Klisch, T.J.2    Schuster, G.3    Zoghbi, H.Y.4
  • 29
    • 0027404833 scopus 로고
    • Ultrastructural evidence for hair cell regeneration in the mammalian inner ear
    • FORGE A, LI L, CORWIN JT, NEVILL G (1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 259:1616-1619
    • (1993) Science , vol.259 , pp. 1616-1619
    • Forge, A.1    I, L.L.2    Corwin, J.T.3    Nevill, G.4
  • 30
    • 19544388583 scopus 로고    scopus 로고
    • Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention
    • FRITZSCH B, MATEI VA, NICHOLS DH, BERMINGHAM N, JONES K, BEISEL KW, WANG VY (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn 233:570-583
    • (2005) Dev Dyn , vol.233 , pp. 570-583
    • Fritzsch, B.1    Matei, V.A.2    Nichols, D.H.3    Bermingham, N.4    Jones, K.5    Beisel, K.W.6    Wang, V.Y.7
  • 31
    • 1442307700 scopus 로고    scopus 로고
    • Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
    • GAZIT R, KRIZHANOVSKY V, BEN-ARIE N (2004) Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development 131:903-913
    • (2004) Development , vol.131 , pp. 903-913
    • Gazit, R.1    Krizhanovsky, V.2    Ben-Arie, N.3
  • 32
    • 0035797454 scopus 로고    scopus 로고
    • Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
    • GOWAN K, HELMS AW, HUNSAKER TL, COLLISSON T, EBERT PJ, ODOM R, JOHNSON JE (2001) Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31:219-232
    • (2001) Neuron , vol.31 , pp. 219-232
    • Gowan, K.1    Helms, A.W.2    Hunsaker, T.L.3    Collisson, T.4    Ebert, P.J.5    Odom, R.6    Johnson, J.E.7
  • 33
    • 52949112282 scopus 로고    scopus 로고
    • Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer
    • GUBBELS SP, WOESSNER DW, MITCHELL JC, RICCI AJ, BRIGANDE JV (2008) Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature 455:537-541
    • (2008) Nature , vol.455 , pp. 537-541
    • Gubbels, S.P.1    Woessner, D.W.2    Mitchell, J.C.3    Ricci, A.J.4    Brigande, J.V.5
  • 34
    • 0031889206 scopus 로고    scopus 로고
    • Progenitors of dorsal commissural interneurons are defined by MATH1 expression
    • HELMS AW, JOHNSON JE (1998) Progenitors of dorsal commissural interneurons are defined by MATH1 expression. Development 125:919-928
    • (1998) Development , vol.125 , pp. 919-928
    • Helms, A.W.1    Johnson, J.E.2
  • 35
    • 0034029614 scopus 로고    scopus 로고
    • Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
    • HELMS AW, ABNEY AL, BEN-ARIE N, ZOGHBI HY, JOHNSON JE (2000) Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 127:1185-1196
    • (2000) Development , vol.127 , pp. 1185-1196
    • Helms, A.W.1    Abney, A.L.2    Ben-Arie, N.3    Zoghbi, H.Y.4    Johnson, J.E.5
  • 36
    • 77950114795 scopus 로고    scopus 로고
    • Sonic hedgehog (SHH) promotes the differentiation of mouse cochlear neural progenitors via the Math1-Brn3.1 signaling pathway in vitro
    • HU X, HUANG J, FENG L, FUKUDOME S, HAMAJIMA Y, LIN J (2010) Sonic hedgehog (SHH) promotes the differentiation of mouse cochlear neural progenitors via the Math1-Brn3.1 signaling pathway in vitro. J Neurosci Res 88:927-935
    • (2010) J Neurosci Res , vol.88 , pp. 927-935
    • U, X.H.1    Huang, J.2    Feng, L.3    Fukudome, S.4    Hamajima, Y.5    Lin, J.6
  • 40
    • 77955407251 scopus 로고    scopus 로고
    • Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea
    • JAHAN I, PAN N, KERSIGO J, FRITZSCH B (2010) Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea. PLoS One 5:e11661
    • (2010) PLoS One , vol.5
    • Jahan, I.1    Pan, N.2    Kersigo, J.3    Fritzsch, B.4
  • 41
    • 0027233365 scopus 로고
    • Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
    • JARMAN AP, GRAU Y, JAN LY, JAN YN (1993) atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell 73:1307-1321
    • (1993) Cell , vol.73 , pp. 1307-1321
    • Jarman, A.P.1    Grau, Y.2    Jan, L.Y.3    Jan, Y.N.4
  • 42
    • 32544457518 scopus 로고    scopus 로고
    • Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti
    • JONES JM, MONTCOUQUIOL M, DABDOUB A, WOODS C, KELLEY MW (2006) Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci 26:550-558
    • (2006) J Neurosci , vol.26 , pp. 550-558
    • Jones, J.M.1    Montcouquiol, M.2    Dabdoub, A.3    Woods, C.4    Kelley, M.W.5
  • 43
    • 77956125791 scopus 로고    scopus 로고
    • Id gene regulation and function in the prosensory domains of the chicken inner ear: A link between Bmp signaling and Atoh1
    • KAMAID A, NEVES J, GIRALDEZ F (2010) Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1. J Neurosci 30:11426-11434
    • (2010) J Neurosci , vol.30 , pp. 11426-11434
    • Kamaid, A.1    Neves, J.2    Giraldez, F.3
  • 44
    • 0038118296 scopus 로고    scopus 로고
    • Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo
    • KAWAMOTO K, ISHIMOTO S, MINODA R, BROUGH DE, RAPHAEL Y (2003) Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J Neurosci 23:4395-4400
    • (2003) J Neurosci , vol.23 , pp. 4395-4400
    • Kawamoto, K.1    Ishimoto, S.2    Minoda, R.3    Brough, D.E.4    Raphael, Y.5
  • 45
    • 77956144348 scopus 로고    scopus 로고
    • Atonal homolog 1 is required for growth and differentiation effects of Notch/?-secretase inhibitors on normal and cancerous intestinal epithelial cells
    • e916
    • KAZANJIAN A, NOAH T, BROWN D, BURKART J, SHROYER NF (2010) Atonal homolog 1 is required for growth and differentiation effects of Notch/?-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology 139:918-928.e916
    • (2010) Gastroenterology , vol.139 , pp. 918-928
    • Kazanjian, A.1    Noah, T.2    Brown, D.3    Burkart, J.4    Shroyer, N.F.5
  • 46
    • 0034461606 scopus 로고    scopus 로고
    • Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
    • KENNEY AM, ROWITCH DH (2000) Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Molecular and Cellular Biology 20:9055-9067
    • (2000) Molecular and Cellular Biology , vol.20 , pp. 9055-9067
    • Kenney, A.M.1    Rowitch, D.H.2
  • 47
    • 79953176341 scopus 로고    scopus 로고
    • Genetic evidence that intestinal notch functions vary regionally and operate through a common mechanism of math1 repression
    • KIM TH, SHIVDASANI RA (2011) Genetic evidence that intestinal notch functions vary regionally and operate through a common mechanism of math1 repression. J Biol Chem 286:11427-11433
    • (2011) J Biol Chem , vol.286 , pp. 11427-11433
    • Kim, T.H.1    Shivdasani, R.A.2
  • 48
    • 79952769989 scopus 로고    scopus 로고
    • In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development
    • KLISCH TJ, XI Y, FLORA A, WANG L, LI W, ZOGHBI HY (2011) In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development. Proc Natl Acad Sci 108:3288-3293
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 3288-3293
    • Klisch, T.J.1    I, Y.X.2    Flora, A.3    Wang, L.4    I, W.L.5    Zoghbi, H.Y.6
  • 50
    • 79960939324 scopus 로고    scopus 로고
    • In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord
    • LAI HC, KLISCH TJ, ROBERTS R, ZOGHBI HY, JOHNSON JE (2011) In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. J Neurosci 31:10859-10871
    • (2011) J Neurosci , vol.31 , pp. 10859-10871
    • Lai, H.C.1    Klisch, T.J.2    Roberts, R.3    Zoghbi, H.Y.4    Johnson, J.E.5
  • 53
    • 0034677471 scopus 로고    scopus 로고
    • Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    • LEE KJ, DIETRICH P, JESSELL TM (2000) Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403:734-740
    • (2000) Nature , vol.403 , pp. 734-740
    • Lee, K.J.1    Dietrich, P.2    Jessell, T.M.3
  • 54
    • 4344661366 scopus 로고    scopus 로고
    • Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells
    • LEOW CC, ROMERO MS, ROSS S, POLAKIS P, GAO WQ (2004) Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res 64:6050-6057
    • (2004) Cancer Res , vol.64 , pp. 6050-6057
    • Leow, C.C.1    Romero, M.S.2    Ross, S.3    Polakis, P.4    Gao, W.Q.5
  • 56
    • 0030837815 scopus 로고    scopus 로고
    • Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment
    • LOPEZ I, HONRUBIA V, LEE SC, SCHOEMAN G, BEYKIRCH K (1997) Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment. Int J Dev Neurosci 15:447-461
    • (1997) Int J Dev Neurosci , vol.15 , pp. 447-461
    • Lopez, I.1    Honrubia, V.2    Lee, S.C.3    Schoeman, G.4    Beykirch, K.5
  • 57
    • 25644435002 scopus 로고    scopus 로고
    • Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
    • MACHOLD R, FISHELL G (2005) Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron 48:17-24
    • (2005) Neuron , vol.48 , pp. 17-24
    • MacHold, R.1    Fishell, G.2
  • 59
    • 33745414042 scopus 로고    scopus 로고
    • The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1
    • MUTOH H, SAKAMOTO H, HAYAKAWA H, ARAO Y, SATOH K, NOKUBI M, SUGANO K (2006) The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. Differentiation 74:313-321
    • (2006) Differentiation , vol.74 , pp. 313-321
    • Mutoh, H.1    Sakamoto, H.2    Hayakawa, H.3    Arao, Y.4    Satoh, K.5    Nokubi, M.6    Sugano, K.7
  • 60
    • 1842507209 scopus 로고    scopus 로고
    • Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification
    • NAKADA Y, HUNSAKER TL, HENKE RM, JOHNSON JE (2004) Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification. Development 131:1319-1330
    • (2004) Development , vol.131 , pp. 1319-1330
    • Nakada, Y.1    Hunsaker, T.L.2    Henke, R.M.3    Johnson, J.E.4
  • 61
    • 79951529175 scopus 로고    scopus 로고
    • Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: A mechanism for sensory organ specification
    • NEVES J, PARADA C, CHAMIZO M, GIRALDEZ F (2011) Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification. Development 138:735-744
    • (2011) Development , vol.138 , pp. 735-744
    • Neves, J.1    Parada, C.2    Chamizo, M.3    Giraldez, F.4
  • 62
    • 69049098002 scopus 로고    scopus 로고
    • Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg (Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation
    • PAN N, JAHAN I, LEE JE, FRITZSCH B (2009) Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg (Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation. Cell Tissue Res 337:407-428
    • (2009) Cell Tissue Res , vol.337 , pp. 407-428
    • Pan, N.1    Jahan, I.2    Lee, J.E.3    Fritzsch, B.4
  • 63
    • 79955961631 scopus 로고    scopus 로고
    • Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    • PAN N, JAHAN I, KERSIGO J, KOPECKY B, SANTI P, JOHNSON S, SCHMITZ H, FRITZSCH B (2010) Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res 275:66-80
    • (2010) Hear Res , vol.275 , pp. 66-80
    • Pan, N.1    Jahan, I.2    Kersigo, J.3    Kopecky, B.4    Santi, P.5    Johnson, S.6    Schmitz, H.7    Fritzsch, B.8
  • 65
    • 6344248555 scopus 로고    scopus 로고
    • The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites
    • POWELL LM, ZUR LAGE PI, PRENTICE DRA, SENTHINATHAN B, JARMAN AP (2004) The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol Cell Biol 24:9517-9526
    • (2004) Mol Cell Biol , vol.24 , pp. 9517-9526
    • Powell, L.M.1    Zur Lage, P.I.2    Prentice, D.R.A.3    Senthinathan, B.4    Jarman, A.P.5
  • 66
    • 50849106038 scopus 로고    scopus 로고
    • Specificity of Atonal and Scute bHLH factors: Analysis of cognate e box binding sites and the influence of Senseless
    • POWELL LM, DEATON AM, WEAR MA, JARMAN AP (2008) Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless. Genes Cells 13:915-929
    • (2008) Genes Cells , vol.13 , pp. 915-929
    • Powell, L.M.1    Deaton, A.M.2    Wear, M.A.3    Jarman, A.P.4
  • 68
    • 33646883311 scopus 로고    scopus 로고
    • Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear
    • QIAN D, RADDE-GALLWITZ K, KELLY M, TYRBERG B, KIM J, GAO W-Q, CHEN P (2006) Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear. Dev Dyn 235:1689-1700
    • (2006) Dev Dyn , vol.235 , pp. 1689-1700
    • Qian, D.1    Radde-Gallwitz, K.2    Kelly, M.3    Tyrberg, B.4    Kim, J.5    Gao, W.-Q.6    Chen, P.7
  • 70
    • 70350758680 scopus 로고    scopus 로고
    • Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1
    • ROSE MF, AHMAD KA, THALLER C, ZOGHBI HY (2009A) Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Assoc Sci 106:22462-22467
    • (2009) Proc Natl Assoc Sci , vol.106 , pp. 22462-22467
    • Rose, M.F.1    Ahmad, K.A.2    Thaller, C.3    Zoghbi, H.Y.4
  • 72
    • 73649141305 scopus 로고    scopus 로고
    • Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3? enhancer
    • SHI F, CHENG YF, WANG XL, EDGE AS (2010) Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3? enhancer. J Biol Chem 285:392-400
    • (2010) J Biol Chem , vol.285 , pp. 392-400
    • Shi, F.1    Cheng, Y.F.2    Wang, X.L.3    Edge, A.S.4
  • 73
    • 26944474424 scopus 로고    scopus 로고
    • Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
    • SHROYER NF, WALLIS D, VENKEN KJ, BELLEN HJ, ZOGHBI HY (2005) Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev 19:2412-2417
    • (2005) Genes Dev , vol.19 , pp. 2412-2417
    • Shroyer, N.F.1    Wallis, D.2    Venken, K.J.3    Bellen, H.J.4    Zoghbi, H.Y.5
  • 74
    • 0042162894 scopus 로고    scopus 로고
    • Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear
    • STEVENS CB, DAVIES AL, BATTISTA S, LEWIS JH, FEKETE DM (2003) Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev Biol 261:149-164
    • (2003) Dev Biol , vol.261 , pp. 149-164
    • Stevens, C.B.1    Davies, A.L.2    Battista, S.3    Lewis, J.H.4    Fekete, D.M.5
  • 75
    • 77956883150 scopus 로고    scopus 로고
    • Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
    • VANDUSSEN KL, SAMUELSON LC (2010) Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol 346:215-223
    • (2010) Dev Biol , vol.346 , pp. 215-223
    • Vandussen, K.L.1    Samuelson, L.C.2
  • 77
    • 0037125941 scopus 로고    scopus 로고
    • Drosophila atonal fully rescues the phenotype of Math1 null mice: New functions evolve in new cellular contexts
    • WANG VY, HASSAN BA, BELLEN HJ, ZOGHBI HY (2002) Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts. Curr Biol 12:1611-1616
    • (2002) Curr Biol , vol.12 , pp. 1611-1616
    • Wang, V.Y.1    Hassan, B.A.2    Bellen, H.J.3    Zoghbi, H.Y.4
  • 78
    • 25644444642 scopus 로고    scopus 로고
    • Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum
    • WANG VY, ROSE MF, ZOGHBI HY (2005) Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron 48:31-43
    • (2005) Neuron , vol.48 , pp. 31-43
    • Wang, V.Y.1    Rose, M.F.2    Zoghbi, H.Y.3
  • 80
    • 9444264776 scopus 로고    scopus 로고
    • Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
    • WINE-LEE L, AHN KJ, RICHARDSON RD, MISHINA Y, LYONS KM, CRENSHAW EB, 3RD (2004) Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development 131:5393-5403
    • (2004) Development , vol.131 , pp. 5393-5403
    • Wine-Lee, L.1    Ahn, K.J.2    Richardson, R.D.3    Mishina, Y.4    Lyons, K.M.5    Crenshaw, E.B.6
  • 81
    • 13744263559 scopus 로고    scopus 로고
    • Math1 regulates development of the sensory epithelium in the mammalian cochlea
    • WOODS C, MONTCOUQUIOL M, KELLEY MW (2004) Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci 7:1310-1318
    • (2004) Nat Neurosci , vol.7 , pp. 1310-1318
    • Woods, C.1    Montcouquiol, M.2    Kelley, M.W.3
  • 82
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • YANG Q, BERMINGHAM NA, FINEGOLD MJ, ZOGHBI HY (2001) Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294:2155-2158
    • (2001) Science , vol.294 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 83
    • 77953526755 scopus 로고    scopus 로고
    • Generation and characterization of Atoh1-Cre knock-in mouse line
    • YANG H, XIE X, DENG M, CHEN X, GAN L (2010) Generation and characterization of Atoh1-Cre knock-in mouse line. Genesis 48:407-413
    • (2010) Genesis , vol.48 , pp. 407-413
    • Yang, H.1    Xie, X.2    Deng, M.3    Chen, X.4    Gan, L.5
  • 84
    • 84865446231 scopus 로고    scopus 로고
    • Identification of Bombyx Atonal and functional comparison with the Drosophila Atonal proneural factor in the developing fly eye
    • in press
    • YU L, ZHOU Q, ZHANG C, PIGNONI F (2011) Identification of Bombyx Atonal and functional comparison with the Drosophila Atonal proneural factor in the developing fly eye. Genesis (in press)
    • (2011) Genesis
    • U, L.Y.1    Zhou, Q.2    Zhang, C.3    Pignoni, F.4
  • 85
    • 41149130332 scopus 로고    scopus 로고
    • Posttranscriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
    • ZHAO H, AYRAULT O, ZINDY F, KIM JH, ROUSSEL MF (2008) Posttranscriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22:722-727
    • (2008) Genes Dev , vol.22 , pp. 722-727
    • Zhao, H.1    Ayrault, O.2    Zindy, F.3    Kim, J.H.4    Roussel, M.F.5
  • 86
    • 0034127584 scopus 로고    scopus 로고
    • Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
    • ZHENG JL, GAO WQ (2000) Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci 3:580-586
    • (2000) Nat Neurosci , vol.3 , pp. 580-586
    • Zheng, J.L.1    Gao, W.Q.2
  • 87
    • 0035400075 scopus 로고    scopus 로고
    • Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear
    • ZINE A, AUBERT A, QIU J, THERIANOS S, GUILLEMOT F, KAGEYAMA R, DE RIBAUPIERRE F (2001) Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci 21:4712-4720
    • (2001) J Neurosci , vol.21 , pp. 4712-4720
    • Zine, A.1    Aubert, A.2    Qiu, J.3    Therianos, S.4    Guillemot, F.5    Kageyama, R.6    De Ribaupierre, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.