Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells

Nature Neuroscience

Volumn 2, Issue 6, 1999, Pages 535-540

  Alder, Janet ^a   Lee, Kevin J ^b   Jessell, Thomas M ^b   Hatten, Mary E ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GROWTH FACTOR;

ANIMAL CELL; ARTICLE; BRAIN FUNCTION; CELL TRANSPLANTATION; CEREBELLUM CORTEX; EMBRYO; GRANULE CELL; MESENCEPHALON; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANIMALS, NEWBORN; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CEREBELLUM; GENE EXPRESSION; HUMANS; MICE; MULTIGENE FAMILY; NEURONS; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE DISTRIBUTION;

EID: 0033363492     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/9189     Document Type: Article

References (50)

1. Ito, M. The Cerebellum and Neural Control (Raven, New York, 1984).
2. Gao, J. H. et al. Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272, 545-547 (1996).
3. Fiez, J. A. Cerebellar contributions to cognition. Neuron 16, 13-15 (1996).
4. Eccles, J. C., Ito, M. & Szentágothai, J. The Cerebellum as a Neuronal Machine (Springer, New York, 1967).
5. Peringa, J., Fung, K. M., Muragaki, Y. & Trojanowski, J. Q. The cellular and molecular biology of medulloblastoma. Curr. Opin. Neurol. 8, 437-440 (1995).
6. Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997).
7. Martinez, S. & Alvarado-Mallart, R. M. Rostral cerebellum originates from the caudal portion of the so-called 'mesencephalic' vesicle: a study using chick/quail chimeras. Eur. J. Neurosci. 1, 549-560 (1989).
8. Altman, J. & Bayer, S. A. The Development of the Cerebellar System: In Relation to its Evolution, Structure, and Functions (CRC, New York, 1997).
9. Hatten, M. E. & Heintz, N. Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci. 18, 385-408 (1995).
10. Lumsden, A. & Krumlauf, R. Patterning the vertebrate neuraxis. Science 274, 1109-1115 (1996).
11. Joyner, A. L. Engrailed, wnt and pax genes regulate midbrain-hindbrain development. Trends Genet. 12, 15-20 (1996).
12. McMahon, A. P., Joyner, A. L., Bradley, A. & McMahon, J. A. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581-595 (1992).
13. Crossley, P. H., Martinez, S. & Martin, G. R. Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68 (1996).
14. Hallonet, M. E. & Le Douarin, N. M. Tracing neuroepithelial cells of the mesencephalic and metencephalic alar plates during cerebellar ontogeny in quail-chick chimaeras. Eur. J. Neurosci. 5, 1145-1155 (1993).
15. Ryder, E. F. & Cepko, C. L. Migration patterns of clonally related granule cells and their progenitors in the developing chick cerebellum. Neuron 12, 1011-1028 (1994).
16. Alder, J., Cho, N. K. & Hatten, M. E. Embryonic precursor cells from the rhombic lip are specified to a cerebellar granule neuron identity. Neuron 17, 389-399 (1996).
17. Aruga, J. et al. A novel zinc finger protein, Zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J. Neurochem. 63, 1880-1890 (1994).
18. Nagai, T. et al. The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev. Biol. 182, 299-313 (1997).
19. Akazawa, C., Ishibashi, M., Shimizu, C., Nakanishi, S. & Kageyama, R. A mammalian helix-loop-helix factor structurally related the the product of the Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270, 8730-8738 (1995).
20. Ben-Arie, N. et al. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Human Mol. Genet. 5, 1207-1216 (1996).
21. Helms, A. W. & Johnson, J. E. Progenitors of dorsal commissural interneurons are defined by Math1 expression. Development 125, 919-928 (1998).
22. Ben-Arie, N. et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 390, 169-172 (1997).
23. Liem, K. F. Jr., Tremml, G., Roelink, H. & Jessell, T. M. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979 (1995).
24. Liem, K. F. Jr., Tremml, G. & Jessell, T. M. A role for the roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91, 127-138 (1997).
25. Arkell, R. & Beddington, R. S. BMP7 influences pattern and growth of the developing hindbrain of mouse embryos. Development 124, 1-12 (1997).
26. Furuta, Y., Piston, D. W. & Hogan, B. L. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124, 2203-2212 (1997).
27. Lee, K. J., Mendelsohn, M. & Jessell, T. M. Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the spinal cord. Genes Dev. 12, 3394-3407 (1998).
28. Muhr, J., Jessell, T. M. & Edlund, T. Assignment of early caudal identity to neural plate cells by a signal from caudal paraxial mesoderm. Neuron 19, 487-502 (1997).
29. Kuhar, S. G. et al. Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation. Development 117, 97-104 (1993).
30. Gao, W.-Q. & Hatten, M. E. Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum. Development 120, 1059-1070 (1994).
31. Graham, A., Francis, W. P., Brickell, P. & Lumsden, A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686 (1994).
32. Lumsden, A., Sprawson, N. & Graham, A. Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281-1291 (1991).
33. Tan, S. S. & Morriss-Kay, G. The development and distribution of the cranial neural crest in the rat embryo. Cell Tissue Res. 240, 403-416 (1985).
34. Chan, W. Y. & Tam, P. P. A morphological and experimental study of the mesencephalic neural crest cells in the mouse embryo using wheat germ agglutinin-gold conjugate as the cell marker. Development 102, 427-442 (1988).
35. Serbedzija, G. N., Bronner-Fraser, M. & Fraser, S. E. Vital dye analysis of cranial neural crest cell migration in the mouse embryo. Development 116, 297-307 (1992).
36. Osumi-Yamashita, N., Ninomiya, Y., Doi, H. & Eto, K. The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos. Dev. Biol. 164, 409-419 (1994).
37. Gao, W.-Q., Heintz, N. & Hatten, M. E. Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron 6, 705-715 (1991).
38. Smeyne, R. J. et al. Local control of granule cell generation by cerebellar Purkinje cells. Mol. Cell. Neurosci. 6, 230-251 (1995).
39. Goldowitz, D. & Hamre, K. The cells and molecules that make a cerebellum. Trends Neurosci. 21, 375-382 (1998).
40. Wechsler-Reya, R. & Scott, M. P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22, 103-114 (1999).
41. Shah, N. M., Groves, A. K. & Anderson, D. J. Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members. Cell 85, 331-343 (1996).
42. Gross, R. E. et al. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron 17, 595-606 (1996).
43. Davis, C. A., Holmyard, D. P., Millen, K. J. & Joyner, A. L. Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-298 (1991).
44. Roelink, H. & Nusse, R. Expression of two members of the Wnt family during mouse development: restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 5, 381-388 (1991).
45. Parr, B. A., Shea, M. J., Vassileva, G. & McMahon, A. P. Mouse Wnt genes exhibit discrete domains of expression in its early embryonic CNS and limb buds. Development 119, 247-261 (1993).
46. Schaeren-Wiemers, N. & Gerfin-Moser, A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100, 431-440 (1993).
47. Wilson, P. A. & Hemmati-Brivanlou, A. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376, 331-333 (1995).
48. Yamada, T., Pfaff, S. L., Edlund, T. & Jessell, T. M. Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Cell 73, 673-686 (1993).
49. Gao, W.-Q. & Hatten, M. E. Neuronal differentiation rescued by implantation of weaver granule cell precursors into wild-type cerebellar cortex. Science 260, 367-369 (1993).
50. Arnold, D. B. & Heintz, N. A calcium responsive element that regulates expression of two calcium binding proteins in Purkinje cells. Proc. Natl. Acad. Sci. USA 94, 8842-8847 (1997).