16-Aza-ent-beyerane and 16-aza-ent-trachylobane: Potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana

Journal of the American Chemical Society

Volumn 129, Issue 41, 2007, Pages 12453-12460

  Roy, Arnab ^a,c   Roberts, Frank G ^a,d   Wilderman, P Ross ^b   Zhou, Ke ^b   Peters, Reuben J ^b   Coates, Robert M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c Albany Molecular Sciences   (India)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS THALIANA; CYCLIC STRUCTURES; INHIBITION CONSTANTS; MECHANISTIC HYPOTHESES;

BINDING ENERGY; CHEMICAL BONDS; CYCLIZATION; ENZYME INHIBITION; HYDROLYSIS;

PARAFFINS;

13,16 SECO 16 NORCARBAMATE; 16 AZABEYERANE; 16 AZATRACHYLOBANE; ATISERENE; BEYERAN 16 ONE OXIME; CARBAMIC ACID DERIVATIVE; DITERPENE; ENZYME INHIBITOR; GIBBERELLIN; HETEROCYCLIC COMPOUND; KAURENE SYNTHASE; LEAD; MERCURY; METHYL GROUP; OXIME DERIVATIVE; PYROPHOSPHATE; RECOMBINANT ENZYME; SYNTHETASE; UNCLASSIFIED DRUG;

ARABIDOPSIS; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; COVALENT BOND; CURTIUS REARRANGEMENT; CYCLIZATION; ENZYME INHIBITION; FRAGMENTATION REACTION; HYDROLYSIS; NONHUMAN; PRECURSOR; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; ARABIDOPSIS; AZA COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHATES; TERPENES;

EID: 35348947451     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja072447e     Document Type: Article

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