β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure-activity relationship study

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5924-5929

  Du, Jinfa ^a   Bao, Donghui ^a   Chun, Byoung Kwon ^a   Jiang, Ying ^a   Ganapati Reddy, P ^a   Zhang, Hai Ren ^a   Ross, Bruce S ^a   Bansal, Shalini ^a   Bao, Haiying ^a   Espiritu, Christine ^a   Lam, Angela M ^a   Murakami, Eisuke ^a   Niu, Congrong ^a   Micolochick Steuer, Holly M ^a   Furman, Phillip A ^a   Otto, Michael J ^a   Sofia, Michael J ^a  

^a PHARMASSET INC   (United States)

Author keywords

Antiviral; Cyclic phosphate; HCV; Hepatitis C virus; NS5B; Nucleoside; Nucleotide; Prodrug; PSI 352938; PSI 353661

Indexed keywords

3',5'CYCLIC PHOSPHATE NUCLEOTIDE DERIVATIVE; 9 [BETA DEXTRO 2' DEOXY 2' ALPHA FLUORO 2' BETA C METHYLRIBOFURANOSYL] 2 AMINO 6 ETHOXYPURINE; ANTIVIRUS AGENT; NUCLEOTIDE DERIVATIVE; PRODRUG; PSI 352938; PSI 353661; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL CLONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MAXIMUM PLASMA CONCENTRATION; MITOCHONDRIAL TOXICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; HEPACIVIRUS; HUMANS; LIVER; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOTIDES, CYCLIC; PRODRUGS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HEPATITIS C VIRUS; RATTUS;

EID: 84865499224     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.066     Document Type: Article

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