Adenosine deaminase-like protein 1 (ADAL1): Characterization and substrate specificity in the hydrolysis of N 6- or O 6-substituted purine or 2-aminopurine nucleoside monophosphates

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5902-5914

  Murakami, Eisuke ^a   Bao, Haiying ^a   Mosley, Ralph T ^a   Du, Jinfa ^a   Sofia, Michael J ^a   Furman, Phillip A ^a  

^a PHARMASSET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE; ADENOSINE DEAMINASE LIKE PROTEIN 1; ALKYL GROUP; HYDROLASE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PHOSPHATE; PRODRUG; PURINE NUCLEOSIDE DERIVATIVE; SUGAR; UNCLASSIFIED DRUG; ZINC ION;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR CLONING; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

2-AMINOPURINE; ADENOSINE MONOPHOSPHATE; AMINO ACID SEQUENCE; AMINOHYDROLASES; BIOCATALYSIS; CELL LINE, TUMOR; CLONING, MOLECULAR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROLYSIS; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NUCLEOSIDE DEAMINASES; PHOSPHORYLATION; PURINES; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; ZINC;

EID: 80051912401     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200650j     Document Type: Article

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