Six-membered ring phosphates and phosphonates as model compounds for cyclic phosphate prodrugs: Is the anomeric effect involved in the selective and spontaneous cleavage of cyclic phosphate prodrugs?

Journal of Organic Chemistry

Volumn 74, Issue 1, 2009, Pages 197-205

  Cruz Gregorio, Silvano ^a   Rodriguez Palacios, Vicente ^a   Höpfl, Herbert ^b   Quintero, Leticia ^a   Sartillo Piscil, Fernando ^a  

^a BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANOMERIC EFFECTS; ANTITUMOR AGENTS; ARYL GROUPS; AS MODELS; BIOLOGICAL ACTIVITIES; BOND CLEAVAGES; CHEMICAL EQUATIONS; CYCLIC PHOSPHATES; ELECTRONIC NATURES; HETEROCYCLIC RINGS; LIVER DISEASES; MODE OF ACTIONS; PHOSPHONATES; PRODRUGS; PYRIDYL GROUPS; SIMPLE MODELS;

ATOMIC PHYSICS; CHEMICAL BONDS; CHEMICAL REACTIONS; OZONE WATER TREATMENT; PHOSPHATES; STEREOCHEMISTRY;

POSITIVE IONS;

MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHATES; PHOSPHONIC ACIDS; PRODRUGS; STEREOISOMERISM;

EID: 58149296142     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo8017473     Document Type: Article

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48. First, phosphorylation, then spontaneous conversion (in situ), and finally removal of the phosphate group with lithium aluminium hydride (LAH): (Chemical Equation Presented)