Novel 7α-alkoxy-17α-(4′-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation

Steroids

Volumn 77, Issue 11, 2012, Pages 1123-1132

  Neto, Carina ^a   Oliveira, Maria Cristina ^a   Gano, Lurdes ^a   Marques, Fernanda ^a   Yasuda, Takumi ^b   Thiemann, Thies ^b,c   Kniess, Torsten ^d   Santos, Isabel ^a  

^a INSTITUTO TECNOLÓGICO E NUCLEAR   (Portugal)

^b KYUSHU UNIVERSITY   (Japan)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^d INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

Author keywords

Breast cancer; Estradiol; Estrogen receptor (ER); Imaging; Positron emission tomography (PET); Single photon emission computerized tomography (SPECT)

Indexed keywords

17ALPHA (4' FLUOROPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 17ALPHA (4' IODOPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 3 O (TERT BUTYLDIMETHYLSILYL) 7ALPHA METHOXY 17ALPHA TRIMETHYLSILYLETHYNYLESTRA 1,3,5(10) TRIEN 3,17BETA DIOL; 3 O (TERT BUTYLDIMETHYLSILYL) 7ALPHA METHOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE; 3 O (TERT BUTYLDIMETHYLSILYL) 7ALPHA PROPOXY 17ALPHA TRIMETHYLSILYLETHYNYLESTRA 1,3,5(10) TRIEN 3,17BETA DIOL; 3 O (TERT BUTYLDIMETHYLSILYL) 7ALPHA PROPOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE; 3 O BENZYL 6 OXOESTRA 1,3,5(10) TRIENE 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3'DIOXANE)]; 3 O BENZYL 6ALPHA,7ALPHA EPOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL 7ALPHA METHOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' (5' ,5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL 7ALPHA PROPOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' [5',5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL ESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL ESTRA 1,3,5(10) TRIEN 3,7ALPHA DIOL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL ESTRA 1,3,5(10) TRIENE 3,6 DIOL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 3 O BENZYL ESTRA 1,3,5(10), 6(7) TETRAEN 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 7ALPHA METHOXY 17ALPHA (4' FLUOROPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 7ALPHA METHOXY 17ALPHA (4' IODOPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 7ALPHA METHOXY 17ALPHA ETHYNYLESTRA 1,3,5(10) TRIEN 3,17BETA DIOL; 7ALPHA METHOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE; 7ALPHA METHOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; 7ALPHA PROPOXY 17ALPHA (4' FLUOROPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 7ALPHA PROPOXY 17ALPHA (4' IODOPHENYLETHYNYL)ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; 7ALPHA PROPOXY 17ALPHA ETHYNYLESTRA 1,3,5(10) TRIEN 3,17BETA DIOL; 7ALPHA PROPOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE; 7ALPHA PROPOXYESTRA 1,3,5(10) TRIEN 3 OL 17 ONE 17,17 [2' (5',5' DIMETHYL 1',3' DIOXANE)]; BIOLOGICAL MARKER; CONTRAST MEDIUM; ESTRADIOL DERIVATIVE; ESTROGEN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ETHERIFICATION; ISOTOPE LABELING; LIPOPHILICITY; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

BREAST NEOPLASMS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; FLUORINE; HUMANS; IODINE; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS, HORMONE-DEPENDENT; POSITRON-EMISSION TOMOGRAPHY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84865491838     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.05.004     Document Type: Article

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