Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 30014-30023

  Rama, Nicolas ^a   Goldschneider, David ^a   Corset, Véronique ^a   Lambert, Jérémy ^a   Pays, Laurent ^a   Mehlen, Patrick ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT BRAIN; ALZHEIMER DISEASE; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; AXON GUIDANCES; GROWTH CONES; INTRACELLULAR SIGNALING; MULTIFUNCTIONAL PROTEIN; NEGATIVE REGULATORS; RECEPTOR COMPLEX; TRANSMEMBRANE RECEPTORS;

BIOCHEMISTRY; BIOLOGY;

GLYCOPROTEINS;

AMYLOID PRECURSOR PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NETRIN 1; PROTEIN DCC; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC TRANSFECTION; GROWTH CONE; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; GROWTH CONES; MICE; MICE, MUTANT STRAINS; NERVE GROWTH FACTORS; PROTEOLYSIS; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 84865455602     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.324780     Document Type: Article

References (39)

1. Cirulli, V., and Yebra, M. (2007) Netrins: beyond the brain. Nat. Rev. Mol. Cell Biol. 8, 296-306
2. Castets, M., and Mehlen, P. (2010) Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor? Cell Cycle 9, 1466-1471
3. Castets, M., Coissieux, M. M., Delloye-Bourgeois, C., Bernard, L., Delcros, J. G., Bernet, A., Laudet, V., and Mehlen, P. (2009) Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Dev. Cell 16, 614-620
4. Serafini, T., Kennedy, T. E., Galko, M. J., Mirzayan, C., Jessell, T. M., and Tessier-Lavigne, M. (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424
5. Tessier-Lavigne, M., and Goodman, C. S. (1996) The molecular biology of axon guidance. Science 274, 1123-1133
6. Serafini, T., Colamarino, S. A., Leonardo, E. D., Wang, H., Beddington, R., Skarnes, W. C., and Tessier-Lavigne, M. (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014
7. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S., Culotti, J. G., and Tessier-Lavigne, M. (1996) Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 87, 175-185
8. Leonardo, E. D., Hinck, L., Masu, M., Keino-Masu, K., Ackerman, S. L., and Tessier-Lavigne, M. (1997) Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838
9. Corset, V., Nguyen-Ba-Charvet, K. T., Forcet, C., Moyse, E., Chédotal, A., and Mehlen, P. (2000) Netrin-1-mediated axon outgrowth and cAMP production require interaction with adenosine A2b receptor. Nature 407, 747-750
10. Ly, A., Nikolaev, A., Suresh, G., Zheng, Y., Tessier-Lavigne, M., and Stein, E. (2008) DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell 133, 1241-1254
11. Fazeli, A., Dickinson, S. L., Hermiston, M. L., Tighe, R. V., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino-Masu, K., Masu, M., Rayburn, H., Simons, J., Bronson, R. T., Gordon, J. I., Tessier-Lavigne, M., and Weinberg, R. A. (1997) Phenotype of mice lacking functional deleted in colorectal cancer (Dcc) gene. Nature 386, 796-804
12. Mehlen, P., and Fearon, E. R. (2004) Role of the dependence receptor DCC in colorectal cancer pathogenesis. J. Clin. Oncol. 22, 3420-3428
13. Li, X., Saint-Cyr-Proulx, E., Aktories, K., and Lamarche-Vane, N. (2002) Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207-15214
14. Forcet, C., Stein, E., Pays, L., Corset, V., Llambi, F., Tessier-Lavigne, M., and Mehlen, P. (2002) Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417, 443-447
15. Ren, X. R., Ming, G. L., Xie, Y., Hong, Y., Sun, D. M., Zhao, Z. Q., Feng, Z., Wang, Q., Shim, S., Chen, Z. F., Song, H. J., Mei, L., and Xiong, W. C. (2004) Focal adhesion kinase in netrin-1 signaling. Nat. Neurosci. 7, 1204-1212
16. Li, W., Lee, J., Vikis, H. G., Lee, S. H., Liu, G., Aurandt, J., Shen, T. L., Fearon, E. R., Guan, J. L., Han, M., Rao, Y., Hong, K., and Guan, K. L. (2004) Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat. Neurosci. 7, 1213-1221
17. Stein, E., and Tessier-Lavigne, M. (2001) Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo-DCC receptor complex. Science 291, 1928-1938
18. Charron, F., Stein, E., Jeong, J., McMahon, A. P., and Tessier-Lavigne, M. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113, 11-23
19. Okada, A., Charron, F., Morin, S., Shin, D. S., Wong, K., Fabre, P. J., Tessier-Lavigne, M., and McConnell, S. K. (2006) Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444, 369-373
20. Lourenço, F. C., Galvan, V., Fombonne, J., Corset, V., Llambi, F., Müller, U., Bredesen, D. E., and Mehlen, P. (2009) Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production. Cell Death Differ. 16, 655-663
21. Hansen, L. A., and Terry, R. D. (1997) Position paper on diagnostic criteria for Alzheimer disease. Neurobiol. Aging 18, S71-S73
22. Koo, E. H. (2002) The β-amyloid precursor protein (APP) and Alzheimer disease: does the tail wag the dog? Traffic 3, 763-770
23. Turner, P. R., O'Connor, K., Tate, W. P., and Abraham, W. C. (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity, and memory. Prog. Neurobiol. 70, 1-32
24. Magara, F., Müller, U., Li, Z. W., Lipp, H. P., Weissmann, C., Stagljar, M., and Wolfer, D. P. (1999) Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the β-amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 96, 4656-4661
25. Mazelin, L., Bernet, A., Bonod-Bidaud, C., Pays, L., Arnaud, S., Gespach, C., Bredesen, D. E., Scoazec, J. Y., and Mehlen, P. (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431, 80-84
26. Mehlen, P., Rabizadeh, S., Snipas, S. J., Assa-Munt, N., Salvesen, G. S., and Bredesen, D. E. (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395, 801-804
27. Taniguchi, Y., Kim, S. H., and Sisodia, S. S. (2003) Presenilin-dependent "γ-secretase" processing of deleted in colorectal cancer (DCC). J. Biol. Chem. 278, 30425-30428
28. Llambi, F., Causeret, F., Bloch-Gallego, E., and Mehlen, P. (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J. 20, 2715-2722
29. Furne, C., Rama, N., Corset, V., Chédotal, A., and Mehlen, P. (2008) Netrin-1 is a survival factor during commissural neuron navigation. Proc. Natl. Acad. Sci. U.S.A. 105, 14465-14470
30. Goldschneider, D., Rama, N., Guix, C., and Mehlen, P. (2008) The neogenin intracellular domain regulates gene transcription via nuclear translocation. Mol. Cell. Biol. 28, 4068-4079
31. Heber, S., Herms, J., Gajic, V., Hainfellner, J., Aguzzi, A., Rülicke, T., von Kretzschmar, H., von Koch, C., Sisodia, S., Tremml, P., Lipp, H. P., Wolfer, D. P., and Müller, U. (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20, 7951-7963
32. Parent, A. T., Barnes, N. Y., Taniguchi, Y., Thinakaran, G., and Sisodia, S. S. (2005) Presenilin attenuates receptor-mediated signaling and synaptic function. J. Neurosci. 25, 1540-1549
33. Hong, K., Nishiyama, M., Henley, J., Tessier-Lavigne, M., and Poo, M. (2000) Calcium signaling in the guidance of nerve growth by netrin-1. Nature 403, 93-98
34. Yang, L., Garbe, D. S., and Bashaw, G. J. (2009) A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance. Science 324, 944-947
35. Hong, K., Hinck, L., Nishiyama, M., Poo, M. M., Tessier-Lavigne, M., and Stein, E. (1999) A ligand-gated association between cytoplasmic domains of UNC-5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941
36. Stein, E., Zou, Y., Poo, M., and Tessier-Lavigne, M. (2001) Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2b receptor activation. Science 291, 1976-1982
37. Mille, F., Llambi, F., Guix, C., Delloye-Bourgeois, C., Guenebeaud, C., Castro-Obregon, S., Bredesen, D. E., Thibert, C., and Mehlen, P. (2009) Interfering with multimerization of netrin-1 receptors triggers tumor cell death. Cell Death Differ. 16, 1344-1351
38. Shewan, D., Dwivedy, A., Anderson, R., and Holt, C. E. (2002) Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway. Nat. Neurosci. 5, 955-962
39. Lu, D. C., Soriano, S., Bredesen, D. E., and Koo, E. H. (2003) Caspase cleavage of the amyloid precursor protein modulates amyloid β-protein toxicity. J. Neurochem. 87, 733-741