Deacetylation of H4-K16Ac and heterochromatin assembly in senescence

Epigenetics and Chromatin

Volumn 5, Issue 1, 2012, Pages

  Contrepois, Kévin ^a   Thuret, Jean Yves ^a   Courbeyrette, Régis ^a   Fenaille, François ^a   Mann, Carl ^a,b  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b CEA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A1A PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; HISTONE DEACETYLASE 3; HISTONE H4; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P16; SIRTUIN 2; TRICHOSTATIN A;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; DEACETYLATION; FEMALE; HETEROCHROMATIN; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE;

MAMMALIA;

EID: 84865419712     PISSN: None     EISSN: 17568935     Source Type: Journal    
DOI: 10.1186/1756-8935-5-15     Document Type: Article

References (61)

1. Facultative heterochromatin: is there a distinctive molecular signature? Trojer P, Reinberg D, Mol Cell 2007 28 1 1 13 10.1016/j.molcel.2007.09.011 17936700 (Pubitemid 47531977)
2. Chromatin modifications and their function. Kouzarides T, Cell 2007 128 4 693 705 10.1016/j.cell.2007.02.005 17320507 (Pubitemid 46273577)
3. NAD+dependent deacetylation of H4 lysine 16 by class III HDACs. Vaquero A, Sternglanz R, Reinberg D, Oncogene 2007 26 37 5505 5520 10.1038/sj.onc. 1210617 17694090 (Pubitemid 47255931)
4. The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association. Allahverdi A, Yang R, Korolev N, Fan Y, Davey CA, Liu CF, Nordenskiold L, Nucleic Acids Res 2011 39 5 1680 1691 10.1093/nar/gkq900 21047799
5. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL, Science 2006 311 5762 844 847 10.1126/science.1124000 16469925 (Pubitemid 43228847)
6. - 30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. Robinson PJ, An W, Routh A, Martino F, Chapman L, Roeder RG, Rhodes D, J Mol Biol 2008 381 4 816 825 10.1016/j.jmb.2008.04.050 18653199
7. Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Zippo A, Serafini R, Rocchigiani M, Pennacchini S, Krepelova A, Oliviero S, Cell 2009 138 6 1122 1136 10.1016/j.cell.2009.07.031 19766566
8. Reconstitution of heterochromatin-dependent transcriptional gene silencing. Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D, Mol Cell 2009 35 6 769 781 10.1016/j.molcel.2009.07.030 19782027
9. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Jeppesen P, Turner BM, Cell 1993 74 2 281 289 10.1016/0092-8674(93)90419-Q 8343956 (Pubitemid 23221704)
10. The MSL complex: X chromosome and beyond. Laverty C, Lucci J, Akhtar A, Curr Opin Genet Dev 2010 20 2 171 178 10.1016/j.gde.2010.01.007 20167472
11. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Smith ER, Cayrou C, Huang R, Lane WS, Cote J, Lucchesi JC, Mol Cell Biol 2005 25 21 9175 9188 10.1128/MCB.25.21.9175-9188.2005 16227571 (Pubitemid 41507821)
12. hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A, Mol Cell Biol 2005 25 15 6798 6810 10.1128/MCB.25.15.6798- 6810.2005 16024812 (Pubitemid 41023250)
13. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK, Mol Cell Biol 2008 28 1 397 409 10.1128/MCB.01045-07 17967868
14. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y, Mol Cell Biol 2010 30 22 5335 5347 10.1128/MCB.00350-10 20837706
15. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Mol Cell Biol 2010 30 14 3582 3595 10.1128/MCB.01476-09 20479123
16. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D, Genes Dev 2006 20 10 1256 1261 10.1101/gad.1412706 16648462 (Pubitemid 43727586)
17. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D, Mol Cell 2004 16 1 93 105 10.1016/j.molcel.2004.08.031 15469825 (Pubitemid 39330155)
18. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP, Nat Struct Mol Biol 2010 17 9 1144 1151 10.1038/nsmb.1899 20802485
19. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. North BJ, Verdin E, PLoS One 2007 2 8 784 10.1371/journal.pone.0000784 17726514 (Pubitemid 351386023)
20. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Adams PD, Gene 2007 397 1-2 84 93 17544228 (Pubitemid 46992697)
21. The essence of senescence. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS, Genes Dev 2010 24 22 2463 2479 10.1101/gad.1971610 21078816
22. Four faces of cellular senescence. Rodier F, Campisi J, J Cell Biol 2011 192 4 547 556 10.1083/jcb.201009094 21321098
23. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW, Cell 2003 113 6 703 716 10.1016/S0092-8674(03) 00401-X 12809602 (Pubitemid 36724935)
24. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Narita M, Krizhanovsky V, Nunez S, Chicas A, Hearn SA, Myers MP, Lowe SW, Cell 2006 126 3 503 514 10.1016/j.cell.2006.05.052 16901784 (Pubitemid 44163608)
25. Loss of linker histone H1 in cellular senescence. Funayama R, Saito M, Tanobe H, Ishikawa F, J Cell Biol 2006 175 6 869 880 10.1083/jcb.200604005 17158953 (Pubitemid 44969193)
26. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD, Dev Cell 2005 8 1 19 30 10.1016/j.devcel.2004.10.019 15621527 (Pubitemid 40058002)
27. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS, Nature 2005 436 7051 720 724 10.1038/nature03890 16079850 (Pubitemid 41117276)
28. Ultra-high performance liquid chromatography-mass spectrometry for the fast profiling of histone post-translational modifications. Contrepois K, Ezan E, Mann C, Fenaille F, J Proteome Res 2010 9 10 5501 5509 10.1021/pr100497a 20707390
29. Parallel pathways in RAF-induced senescence and conditions for its reversion. Jeanblanc M, Ragu S, Gey C, Contrepois K, Courbeyrette R, Thuret JY, Mann C, Oncogene 2012 31 25 3072 3085 10.1038/onc.2011.481 22020327
30. DNA damage checkpoint kinase Chk2 triggers replicative senescence. Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V, EMBO J 2004 23 13 2554 2563 10.1038/sj.emboj.7600259 15192702 (Pubitemid 38988227)
31. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD, Genes Dev 2002 16 17 2225 2230 10.1101/gad.1014902 12208845 (Pubitemid 35013085)
32. Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Pesavento JJ, Yang H, Kelleher NL, Mizzen CA, Mol Cell Biol 2008 28 1 468 486 10.1128/MCB.01517-07 17967882
33. Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. Pesavento JJ, Bullock CR, LeDuc RD, Mizzen CA, Kelleher NL, J Biol Chem 2008 283 22 14927 14937 10.1074/jbc.M709796200 18381279
34. Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown. Plazas-Mayorca MD, Bloom JS, Zeissler U, Leroy G, Young NL, DiMaggio PA, Krugylak L, Schneider R, Garcia BA, Mol Biosyst 2010 6 9 1719 1729 10.1039/c003307c 20577673
35. Genomic characterization reveals a simple histone H4 acetylation code. Dion MF, Altschuler SJ, Wu LF, Rando OJ, Proc Natl Acad Sci USA 2005 102 15 5501 5506 10.1073/pnas.0500136102 15795371 (Pubitemid 40530287)
36. Global turnover of histone post-translational modifications and variants in human cells. Zee BM, Levin RS, Dimaggio PA, Garcia BA, Epigenetics Chromatin 2010 3 1 22 10.1186/1756-8935-3-22 21134274
37. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M, Oncogene 2006 25 2 176 185 16170353 (Pubitemid 43083679)
38. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF, Oncogene 2009 28 6 781 791 10.1038/onc.2008.436 19060927
39. The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? Taddei A, Roche D, Bickmore WA, Almouzni G, EMBO Rep 2005 6 6 520 524 10.1038/sj.embor.7400441 15940285 (Pubitemid 40973959)
40. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Munro J, Barr NI, Ireland H, Morrison V, Parkinson EK, Exp Cell Res 2004 295 2 525 538 10.1016/j.yexcr.2004.01.017 15093749 (Pubitemid 38490504)
41. Autophagy mediates the mitotic senescence transition. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavare S, Arakawa S, Shimizu S, Watt FM, Genes Dev 2009 23 7 798 803 10.1101/gad.519709 19279323
42. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J, Cell Cycle 2011 10 3 457 468 10.4161/cc.10.3.14707 21248468
43. Reversal of human cellular senescence: roles of the p53 and p16 pathways. Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J, EMBO J 2003 22 16 4212 4222 10.1093/emboj/cdg417 12912919 (Pubitemid 37021749)
44. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, Zuffo R, Matti V, Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, dAdda di Fagagna F, Nat Cell Biol 2011 13 3 292 302 10.1038/ncb2170 21336312
45. Diversity, topographic differentiation, and positional memory in human fibroblasts. Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO, Proc Natl Acad Sci U S A 2002 99 20 12877 12882 10.1073/pnas.162488599 12297622
46. Histone H4 lysine 16 acetylation regulates cellular lifespan. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL, Nature 2009 459 7248 802 807 10.1038/nature08085 19516333
47. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Krishnan V, Chow MZ, Wang Z, Zhang L, Liu B, Liu X, Zhou Z, Proc Natl Acad Sci USA 2011 108 30 12325 12330 10.1073/pnas.1102789108 21746928
48. Differential acetylation of core histones in rat cerebral cortex neurons during development and aging. Pina B, Martinez P, Suau P, Eur J Biochem 1988 174 2 311 315 10.1111/j.1432-1033.1988.tb14099.x 3383848
49. Organismal differences in post-translational modifications in histones H3 and H4. Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Allis CD, Hunt DF, J Biol Chem 2007 282 10 7641 7655 17194708 (Pubitemid 47093632)
50. Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. Sarg B, Koutzamani E, Helliger W, Rundquist I, Lindner HH, J Biol Chem 2002 277 42 39195 39201 10.1074/jbc.M205166200 12154089 (Pubitemid 35190888)
51. Age-associated increase in heterochromatic marks in murine and primate tissues. Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM, Aging Cell 2011 10 2 292 304 10.1111/j.1474-9726.2010.00666.x 21176091
52. Lamin A-dependent nuclear defects in human aging. Scaffidi P, Misteli T, Science 2006 312 5776 1059 1063 10.1126/science.1127168 16645051
53. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. Deng Q, Liao R, Wu BL, Sun P, J Biol Chem 2004 279 2 1050 1059 14593117 (Pubitemid 38082626)
54. How does SIRT1 affect metabolism, senescence and cancer? Brooks CL, Gu W, Nat Rev Cancer 2009 9 2 123 128 10.1038/nrc2562 19132007
55. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX, Cancer Cell 2011 20 4 487 499 10.1016/j.ccr.2011.09.004 22014574
56. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs AR, Frontini M, Tora L, EMBO J 2010 29 14 2381 2394 10.1038/emboj.2010.125 20562830
57. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. Pandithage R, Lilischkis R, Harting K, Wolf A, Jedamzik B, Luscher-Firzlaff J, Vervoorts J, Lasonder E, Kremmer E, Knoll B, Lüscher B, J Cell Biol 2008 180 5 915 929 10.1083/jcb.200707126 18332217 (Pubitemid 351398419)
58. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Chicas A, Wang X, Zhang C, McCurrach M, Zhao Z, Mert O, Dickins RA, Narita M, Zhang M, Lowe SW, Cancer Cell 2010 17 4 376 387 10.1016/j.ccr.2010.01.023 20385362
59. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Pérez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M, Nat Genet 2005 37 4 391 400 10.1038/ng1531 15765097
60. DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Jakob B, Splinter J, Conrad S, Voss KO, Zink D, Durante M, Lobrich M, Taucher-Scholz G, Nucleic Acids Res 2011 39 15 6489 6499 10.1093/nar/gkr230 21511815
61. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH, Cell 2011 144 5 732 744 10.1016/j.cell.2011.02. 012 21353298