메뉴 건너뛰기




Volumn 108, Issue SUPPL. 1, 2012, Pages

Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats

Author keywords

Colon cancer; Common beans; Gene expression; Non digestible fractions; Phaseolus vulgaris; Quantitative PCR array

Indexed keywords

AZOXYMETHANE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN BAX;

EID: 84865413009     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512000785     Document Type: Article
Times cited : (36)

References (66)
  • 4
    • 13244275034 scopus 로고    scopus 로고
    • The role of nutrition in cancer development and prevention
    • DOI 10.1002/ijc.20662
    • Michels KB (2005) The role of nutrition in cancer development and prevention. Int J Cancer 114, 163-165. (Pubitemid 40194281)
    • (2005) International Journal of Cancer , vol.114 , Issue.2 , pp. 163-165
    • Michels, K.B.1
  • 7
    • 79953269642 scopus 로고    scopus 로고
    • Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats
    • Vergara-Castañeda HA, Guevara-Gonzalez RG, Ramos-Gómez M, et al. (2010) Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats. Food Funct 1, 294-300.
    • (2010) Food Funct , vol.1 , pp. 294-300
    • Vergara-Castañeda, H.A.1    Guevara-Gonzalez, R.G.2    Ramos-Gómez, M.3
  • 8
    • 68949210323 scopus 로고    scopus 로고
    • Angiotensin-I converting enzyme inhibitory and antioxidant activities of protein hydrolysates from Phaseolus lunatus and Phaseolus vulgaris seeds
    • Torruco-Uco J, Chel-Guerrero L, Mart́nez-Ayala A, et al. (2009) Angiotensin-I converting enzyme inhibitory and antioxidant activities of protein hydrolysates from Phaseolus lunatus and Phaseolus vulgaris seeds. Food Sci Technol 42, 1597-1604.
    • (2009) Food Sci Technol , vol.42 , pp. 1597-1604
    • Torruco-Uco, J.1    Chel-Guerrero, L.2    Mart́nez-Ayala, A.3
  • 9
    • 69749120276 scopus 로고    scopus 로고
    • Chemical composition and in vitro polysaccharide fermentation of different beans (Phaseolus vulgaris L.
    • Campos-Vega R, Reynoso-Camacho R, Pedraza-Aboytes G, et al. (2009) Chemical composition and in vitro polysaccharide fermentation of different beans (Phaseolus vulgaris L.). J Food Sci 74, 59-65.
    • (2009) J Food Sci , vol.74 , pp. 59-65
    • Campos-Vega, R.1    Reynoso-Camacho, R.2    Pedraza-Aboytes, G.3
  • 10
    • 33846707942 scopus 로고    scopus 로고
    • Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B
    • Chen J, Ghazawi FM, Bakkar W, et al. (2006) Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B. Mol Cancer 5, 71.
    • (2006) Mol Cancer , vol.5 , pp. 71
    • Chen, J.1    Ghazawi, F.M.2    Bakkar, W.3
  • 12
    • 67649366235 scopus 로고    scopus 로고
    • Oligosaccharides from human milk induce growth arrest via G2/M by influencing growth-related cell cycle genes in intestinal epithelial cells
    • Kuntz S, Kunz C & Rudloff S (2009) Oligosaccharides from human milk induce growth arrest via G2/M by influencing growth-related cell cycle genes in intestinal epithelial cells. Br J Nutr 101, 1306-1315.
    • (2009) Br J Nutr , vol.101 , pp. 1306-1315
    • Kuntz, S.1    Kunz, C.2    Rudloff, S.3
  • 13
    • 53649095333 scopus 로고    scopus 로고
    • Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer
    • Feregrino-Pérez AA, Berumen LC, Garća-Alcocer G, et al. (2008) Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer. J Agric Food Chem 56, 8737-8744.
    • (2008) J Agric Food Chem , vol.56 , pp. 8737-8744
    • Feregrino-Pérez, A.A.1    Berumen, L.C.2    Garća-Alcocer, G.3
  • 14
    • 77953321174 scopus 로고    scopus 로고
    • Bean (Phaseolus vulgaris L. polysaccharides modulate gene expression in human colon cancer cells (HT-29)
    • Campos-Vega R, Guevara-Gonzalez RG, Guevara-Olvera BL, et al. (2010) Bean (Phaseolus vulgaris L.) polysaccharides modulate gene expression in human colon cancer cells (HT-29). Food Res Int 43, 1057-1064.
    • (2010) Food Res Int , vol.43 , pp. 1057-1064
    • Campos-Vega, R.1    Guevara-Gonzalez, R.G.2    Guevara-Olvera, B.L.3
  • 16
    • 0014875884 scopus 로고
    • Polysaccharide from dry navy beans, Phaseolus vulgaris: Its isolation and stimulation of clostridium perfringens
    • Kurtzman RH & Halbrook WU (1970) Polysaccharide from dry navy beans, Phaseolus vulgaris: its isolation and stimulation of clostridium perfringens. Appl Microbiol 20, 715-719.
    • (1970) Appl Microbiol , vol.20 , pp. 715-719
    • Kurtzman, R.H.1    Halbrook, W.U.2
  • 18
    • 0038751837 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the p53 tumour suppressor
    • DOI 10.1038/sj.cdd.4401191
    • Ho J & Benchimol S (2003) Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 10, 404-408. (Pubitemid 36636906)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.4 , pp. 404-408
    • Ho, J.1    Benchimol, S.2
  • 20
    • 0034830491 scopus 로고    scopus 로고
    • Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation
    • Li L, Rao JN, Guo X, et al. (2001) Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am J Physiol Cell Physiol 281, 941-953.
    • (2001) Am J Physiol Cell Physiol , vol.281 , pp. 941-953
    • Li, L.1    Rao, J.N.2    Guo, X.3
  • 21
    • 0035821788 scopus 로고    scopus 로고
    • P21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents
    • DOI 10.1038/sj.onc.1204440
    • Mahyar-Roemer M & Roemer K (2001) p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene 20, 3387-3398. (Pubitemid 32588987)
    • (2001) Oncogene , vol.20 , Issue.26 , pp. 3387-3398
    • Mahyar-Roemer, M.1    Roemer, K.2
  • 22
    • 2942685963 scopus 로고    scopus 로고
    • Cell cycle checkpoint proteins and cellular to treatment by anticancer agents
    • Damia G & Broggini M (2004) Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents. Cell Cycle 3, 46-50. (Pubitemid 40268586)
    • (2004) Cell Cycle , vol.3 , Issue.1 , pp. 46-50
    • Damia, G.1    Broggini, M.2
  • 24
    • 34248363679 scopus 로고    scopus 로고
    • Restriction beyond the restriction point: Mitogen requirement for G2 passage
    • Foijer F & Te Riele H (2006) Restriction beyond the restriction point: mitogen requirement for G2 passage. Cell Div 1, 1-5.
    • (2006) Cell Div , vol.1 , pp. 1-5
    • Foijer, F.1    Te Riele, H.2
  • 25
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with RB, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • DOI 10.1038/77124
    • Robertson KD, Ait-Si-Ali S, Yokochi T, et al. (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25, 338-342. (Pubitemid 30437325)
    • (2000) Nature Genetics , vol.25 , Issue.3 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 27
    • 77949261504 scopus 로고    scopus 로고
    • Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli
    • Harford TJ, Shaltouki A & Weyman CM (2010) Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis 15, 71-82.
    • (2010) Apoptosis , vol.15 , pp. 71-82
    • Harford, T.J.1    Shaltouki, A.2    Weyman, C.M.3
  • 29
    • 2342619615 scopus 로고    scopus 로고
    • Hypermethylation of the MYOD1 gene is a novel prognostic factor in patients with colorectal cancer
    • Hiranuma C, Kawakami K, Oyama K, et al. (2004) Hypermethylation of the MYOD1 gene is a novel prognostic factor in patients with colorectal cancer. Int J Mol Med 13, 413-417.
    • (2004) Int J Mol Med , vol.13 , pp. 413-417
    • Hiranuma, C.1    Kawakami, K.2    Oyama, K.3
  • 31
    • 0036023401 scopus 로고    scopus 로고
    • Gadd45a: An elusive yet attractive candidate gene in pancreatic cancer
    • Hildesheim J & Fornace AJ (2002) Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. Clin Cancer Res 8, 2475-2479. (Pubitemid 34856328)
    • (2002) Clinical Cancer Research , vol.8 , Issue.8 , pp. 2475-2479
    • Hildesheim, J.1    Fornace Jr., A.J.2
  • 32
    • 36749082147 scopus 로고    scopus 로고
    • Base excision DNA repair defect in Gadd45a-deficient cells
    • DOI 10.1038/sj.onc.1210557, PII 1210557
    • Jung HJ, Kim EH, Mun JY, et al. (2007) Base excision DNA repair defect in Gadd45a-deficient cells. Oncogene 26, 7517-7525. (Pubitemid 350207706)
    • (2007) Oncogene , vol.26 , Issue.54 , pp. 7517-7525
    • Jung, H.J.1    Kim, E.H.2    Mun, J.-Y.3    Park, S.4    Smith, M.L.5    Han, S.S.6    Seo, Y.R.7
  • 33
    • 38749124317 scopus 로고    scopus 로고
    • Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae
    • Li M, Liu L, Wang Z, et al. (2008) Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Oncol Rep 19, 401-406. (Pubitemid 351176100)
    • (2008) Oncology Reports , vol.19 , Issue.2 , pp. 401-406
    • Li, M.1    Liu, L.2    Wang, Z.3    Wang, L.4    Liu, Z.5    Xu, G.6    Lu, S.7
  • 34
    • 84865442073 scopus 로고    scopus 로고
    • DNA double strand break and repair: Mechanisms and involvement in human cancer
    • Sengupta S & Roychoudhury S (2005) DNA double strand break and repair: mechanisms and involvement in human cancer. Int J Hum Genet 5, 1-10.
    • (2005) Int J Hum Genet , vol.5 , pp. 1-10
    • Sengupta, S.1    Roychoudhury, S.2
  • 36
    • 0034725698 scopus 로고    scopus 로고
    • Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression
    • DOI 10.1074/jbc.M905616199
    • Laronga C, Yang HY, Neal C, et al. (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275, 23106-23112. (Pubitemid 30646202)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.30 , pp. 23106-23112
    • Laronga, C.1    Yang, H.-Y.2    Neal, C.3    Lee, M.-H.4
  • 37
    • 21744446405 scopus 로고    scopus 로고
    • Cell cycle arrest by a natural product via G2/M checkpoint
    • Luk SCW, Siu SWF, Lai CK, et al. (2005) Cell cycle arrest by a natural product via G2/M checkpoint. Int J Med Sci 2, 64-69.
    • (2005) Int J Med Sci , vol.2 , pp. 64-69
    • Luk, S.C.W.1    Siu, S.W.F.2    Lai, C.K.3
  • 38
    • 33751296789 scopus 로고    scopus 로고
    • FOXO transcription factors: Key regulators of cell fate
    • DOI 10.1042/BST0340722
    • Lam EWF, Francis RE & Petkovic M (2006) FOXO transcription factors: key regulators of cell fate. Biochem Soc Trans 34, 722-726. (Pubitemid 44796405)
    • (2006) Biochemical Society Transactions , vol.34 , Issue.5 , pp. 722-726
    • Lam, E.W.-F.1    Francis, R.E.2    Petkovic, M.3
  • 39
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • DOI 10.1038/sj.onc.1209086, PII 1209086
    • Greer EL & Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24, 7410-7425. (Pubitemid 41637981)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 41
    • 0034002461 scopus 로고    scopus 로고
    • Integration of positive and negative growth signals during Ras pathway activation in vivo
    • Frame S & Balmain A (2000) Integration of positive and negative growth signals during Ras pathway activation in vivo. Curr Opin Genet Dev 10, 06-113.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 06-113
    • Frame, S.1    Balmain, A.2
  • 42
    • 0842269247 scopus 로고    scopus 로고
    • The importance of p53 location: Nuclear or cytoplasmic zip code?
    • DOI 10.1016/j.drup.2003.10.004
    • O'Brate A & Giannakakou P (2003) The importance of p53 location: nuclear or cytoplasmic zip code? Bax-induced apoptotic cell death. Drug Resist Updat 6, 313-322. (Pubitemid 38173582)
    • (2003) Drug Resistance Updates , vol.6 , Issue.6 , pp. 313-322
    • O'Brate, A.1    Giannakakou, P.2
  • 44
    • 28244479285 scopus 로고    scopus 로고
    • Expression of apoptosis-related genes in livers from rats exposed to sulfur dioxide
    • DOI 10.1016/j.tox.2005.08.016, PII S0300483X05003756
    • Bai J & Meng Z (2005) Expression of apoptosis-related genes in livers from rats exposed to sulfur dioxide. Toxicology 216, 253-260. (Pubitemid 41712014)
    • (2005) Toxicology , vol.216 , Issue.2-3 , pp. 253-260
    • Bai, J.1    Meng, Z.2
  • 45
    • 0033984094 scopus 로고    scopus 로고
    • BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
    • DOI 10.1074/jbc.275.2.1439
    • Ray R, Chen G, Velde CV, et al. (2000) BNIP3 heterodimerizes with Bcl-2/Bcl-XL and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem 275, 1439-1448. (Pubitemid 30051204)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 1439-1448
    • Ray, R.1    Chen, G.2    Velde, C.V.3    Cizeau, J.4    Park, J.H.5    Reed, J.C.6    Daniel Gietz, R.7    Greenberg, A.H.8
  • 47
    • 3042592579 scopus 로고    scopus 로고
    • Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    • DOI 10.1083/jcb.200312030
    • Marsden VS, Ekert PG, Van Delft M, et al. (2004) Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9. J Cell Biol 165, 775-780. (Pubitemid 38821968)
    • (2004) Journal of Cell Biology , vol.165 , Issue.6 , pp. 775-780
    • Marsden, V.S.1    Ekert, P.G.2    Van Delft, M.3    Vaux, D.L.4    Adams, J.M.5    Strasser, A.6
  • 49
    • 0036308059 scopus 로고    scopus 로고
    • Mitochondria, the killer organelles and their weapons
    • DOI 10.1002/jcp.10111
    • Ravagnan L, Roumier T & Kroemer G (2002) Mitochondria, the killer organelles and their weapons. J Cell Physiol 192, 131-137. (Pubitemid 34747781)
    • (2002) Journal of Cellular Physiology , vol.192 , Issue.2 , pp. 131-137
    • Ravagnan, L.1    Roumier, T.2    Kroemer, G.3
  • 50
    • 5644227426 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells
    • DOI 10.1016/j.canlet.2004.06.010, PII S0304383504004276
    • Yu Z, Li W & Liu F (2004) Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215, 159-166. (Pubitemid 39370033)
    • (2004) Cancer Letters , vol.215 , Issue.2 , pp. 159-166
    • Yu, Z.1    Li, W.2    Liu, F.3
  • 52
    • 73449139088 scopus 로고    scopus 로고
    • P63 and p73 transcriptionally regulate genes involved in DNA repair
    • Lin YL, Sengupta S, Gurdziel K, et al. (2009) p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet 5, 1-13.
    • (2009) PLoS Genet , vol.5 , pp. 1-13
    • Lin, Y.L.1    Sengupta, S.2    Gurdziel, K.3
  • 53
    • 0037041392 scopus 로고    scopus 로고
    • P63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • DOI 10.1038/416560a
    • Flores ER, Tsai KY, Crowley D, et al. (2002) p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416, 560-564. (Pubitemid 34288861)
    • (2002) Nature , vol.416 , Issue.6880 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3    Sengupta, S.4    Yang, A.5    McKeon, F.6    Jacks, T.7
  • 54
    • 0037148901 scopus 로고    scopus 로고
    • PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow
    • DOI 10.1038/sj/onc/1205213
    • Haier J & Nicolson GL (2002) PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow. Oncogene 21, 1450-1460. (Pubitemid 34214509)
    • (2002) Oncogene , vol.21 , Issue.9 , pp. 1450-1460
    • Haier, J.1    Nicolson, G.L.2
  • 55
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-κB
    • DOI 10.1016/S1097-2765(04)00131-5, PII S1097276504001315
    • Campbell KJ, Rocha S & Perkins ND (2004) Active repression of antiapoptotic gene expression by RelA (p65) NF-kB. Mol Cell 13, 853-865. (Pubitemid 38438480)
    • (2004) Molecular Cell , vol.13 , Issue.6 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 57
    • 47949129452 scopus 로고    scopus 로고
    • Induction of a pro-apoptotic ATM-NF-kB pathway and its repression by ATR in response to replication stress
    • Wu ZH & Miyamoto S (2008) Induction of a pro-apoptotic ATM-NF-kB pathway and its repression by ATR in response to replication stress. EMBO J 27, 1963-1973.
    • (2008) EMBO J , vol.27 , pp. 1963-1973
    • Zh, W.1    Miyamoto, S.2
  • 58
    • 0142244121 scopus 로고    scopus 로고
    • Oncogene at last - c-Jun promotes liver cancer in mice
    • DOI 10.1016/S1535-6108(03)00025-4
    • Maeda S & Karin M (2003) Oncogene at last c-Jun promotes liver cancer in mice. Cancer Cell 3, 102-104. (Pubitemid 37443382)
    • (2003) Cancer Cell , vol.3 , Issue.2 , pp. 102-104
    • Maeda, S.1    Karin, M.2
  • 59
    • 54449088686 scopus 로고    scopus 로고
    • Interleukin (IL) 1b induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinasedependent AKT/Ib kinase a pathway targeting activator protein-1
    • Cahill CM & Rogers JT (2008) Interleukin (IL) 1b induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinasedependent AKT/Ib kinase a pathway targeting activator protein-1. J Biol Chem 283, 25900-25912.
    • (2008) J Biol Chem , vol.283 , pp. 25900-25912
    • Cahill, C.M.1    Rogers, J.T.2
  • 60
    • 29744443925 scopus 로고    scopus 로고
    • Transcription factor NF-κB: A sensor for smoke and stress signals
    • DOI 10.1196/annals.1352.026
    • Ahn KS & Aggarwal BB (2005) Transcription factor NF-kB. A sensor for smoke and stress signals. Ann NY Acad Sci 1056, 218-233. (Pubitemid 43030980)
    • (2005) Annals of the New York Academy of Sciences , vol.1056 , pp. 218-233
    • Ahn, K.S.1    Aggarwal, B.B.2
  • 62
  • 63
    • 0034725694 scopus 로고    scopus 로고
    • Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase
    • Ohki R, Nemoto J, Murasawa H, et al. (2004) Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem 275, 22627-22630.
    • (2004) J Biol Chem , vol.275 , pp. 22627-22630
    • Ohki, R.1    Nemoto, J.2    Murasawa, H.3
  • 64
    • 3042591342 scopus 로고    scopus 로고
    • Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress
    • DOI 10.1074/jbc.M312135200
    • Nair VD, Yuen T, Olanow CW, et al. (2004) Early single cell bifurcation of pro-and antiapoptotic states during oxidative stress. J Biol Chem 279, 27494-27501. (Pubitemid 38812589)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.26 , pp. 27494-27501
    • Nair, V.D.1    Yuen, T.2    Olanow, C.W.3    Sealfon, S.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.