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Volumn 4, Issue , 2011, Pages 99-124

Mechanobiology of Primary Cilia

Author keywords

Autosomal Dominant Polycystic Kidney Disease; Fluid Shear Stress; Kidney Epithelial Cell; Polycystic Kidney Disease; Primary Cilium

Indexed keywords


EID: 84865378276     PISSN: 18682006     EISSN: 18682014     Source Type: Book Series    
DOI: 10.1007/8415_2010_28     Document Type: Chapter
Times cited : (4)

References (93)
  • 1
    • 65249117068 scopus 로고    scopus 로고
    • Ciliary polycystin 2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades
    • AbouAlaiwi, W.A., Takahashi, M., Mell, B.R., Jones, T.J., Ratnam, S., Kolb, R.J., Nauli, S.M.: Ciliary polycystin 2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Cell Biol. 104(7), 860–869 (2009)
    • (2009) Cell Biol , vol.104 , Issue.7 , pp. 860-869
    • Aboualaiwi, W.A.1    Takahashi, M.2    Mell, B.R.3    Jones, T.J.4    Ratnam, S.5    Kolb, R.J.6    Nauli, S.M.7
  • 2
    • 0017162819 scopus 로고
    • A human syndrome caused by immotile cilia
    • Afzelius, B.A.: A human syndrome caused by immotile cilia. Science 193(4250), 317–319 (1976)
    • (1976) Science , vol.193 , Issue.4250 , pp. 317-319
    • Afzelius, B.A.1
  • 3
    • 0016228408 scopus 로고
    • A scanning electron microscopic study of the nephron
    • Andrews, P.M., Porter, K.R.: A scanning electron microscopic study of the nephron. Am. J. Anat. 140(1), 81–115 (1974)
    • (1974) Am. J. Anat. , vol.140 , Issue.1 , pp. 81-115
    • Andrews, P.M.1    Porter, K.R.2
  • 4
    • 0033598394 scopus 로고    scopus 로고
    • A polycystic kidney-disease gene homologue required for male mating behaviour in C. Elegans
    • Barr, M.M., Sternberg, P.W.: A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature 401(6751), 386–389 (1999)
    • (1999) Nature , vol.401 , Issue.6751 , pp. 386-389
    • Barr, M.M.1    Sternberg, P.W.2
  • 5
    • 74449086803 scopus 로고    scopus 로고
    • Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation
    • Besschetnova, T.Y., Kolpakova-Hart, E., Guan, Y., Zhou, J., Olsen, B.R., Shah, J.V.: Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr. Biol. 20(2), 182–187 (2010)
    • (2010) Curr. Biol. , vol.20 , Issue.2 , pp. 182-187
    • Besschetnova, T.Y.1    Kolpakova-Hart, E.2    Guan, Y.3    Zhou, J.4    Olsen, B.R.5    Shah, J.V.6
  • 6
    • 33751526052 scopus 로고    scopus 로고
    • The roles of cilia in developmental disorders and disease
    • Bisgrove, B.W., Yost, H.J.: The roles of cilia in developmental disorders and disease. Development 133(21), 4131–4143 (2006)
    • (2006) Development , vol.133 , Issue.21 , pp. 4131-4143
    • Bisgrove, B.W.1    Yost, H.J.2
  • 7
    • 0025993792 scopus 로고
    • Determination of ciliary polarity precedes differentiation in the epithelial cells of quail oviduct
    • Boisvieux-Ulrich, E., Sandoz, D.: Determination of ciliary polarity precedes differentiation in the epithelial cells of quail oviduct. Biol. Cell 72(1–2), 3–14 (1991)
    • (1991) Biol. Cell , vol.72 , Issue.1-2 , pp. 3-14
    • Boisvieux-Ulrich, E.1    Sandoz, D.2
  • 8
    • 0024206489 scopus 로고
    • An ultrastructural study of centriolar complexes in adult and embryonic human aortic endothelial cells
    • Bystrevskaya, V.B., Lichkun, V.V., Antonov, A.S., Perov, A.S.: An ultrastructural study of centriolar complexes in adult and embryonic human aortic endothelial cells. Tissue Cell 20(4), 493–503 (1988)
    • (1988) Tissue Cell , vol.20 , Issue.4 , pp. 493-503
    • Bystrevskaya, V.B.1    Lichkun, V.V.2    Antonov, A.S.3    Perov, A.S.4
  • 9
    • 0027519779 scopus 로고
    • Novel heterotrimeric kinesin-related protein purified from sea urchin eggs
    • Cole, D.G., Chinn, S.W., Wedaman, K.P., Hall, K., Vuong, T., Scholey, J.M.: Novel heterotrimeric kinesin-related protein purified from sea urchin eggs. Nature 366(6452), 268–270 (1993)
    • (1993) Nature , vol.366 , Issue.6452 , pp. 268-270
    • Cole, D.G.1    Chinn, S.W.2    Wedaman, K.P.3    Hall, K.4    Vuong, T.5    Scholey, J.M.6
  • 10
    • 27944469172 scopus 로고    scopus 로고
    • An incredible decade for the primary cilium: A look at a once-forgotten organelle
    • Davenport, J.R., Yoder, B.K.: An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am. J. Physiol. Renal Physiol. 289(6), F1159–F1169 (2005)
    • (2005) Am. J. Physiol. Renal Physiol. , vol.289 , Issue.6 , pp. F1159-F1169
    • Davenport, J.R.1    Yoder, B.K.2
  • 12
    • 0041622973 scopus 로고    scopus 로고
    • Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport
    • Donahue, T.L.H., Haut, T.R., Yellowley, C.E., Donahue, H.J., Jacobs, C.R.: Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J. Biomech. 36(9), 1363–1371 (2003)
    • (2003) J. Biomech. , vol.36 , Issue.9 , pp. 1363-1371
    • Donahue, T.L.H.1    Haut, T.R.2    Yellowley, C.E.3    Donahue, H.J.4    Jacobs, C.R.5
  • 13
    • 34147096000 scopus 로고    scopus 로고
    • Structural insights into microtubule doublet interactions in axonemes
    • Downing, K.H., Sui, H.: Structural insights into microtubule doublet interactions in axonemes. Curr. Opin. Struct. Biol. 17(2), 253–259 (2007)
    • (2007) Curr. Opin. Struct. Biol. , vol.17 , Issue.2 , pp. 253-259
    • Downing, K.H.1    Sui, H.2
  • 14
    • 0016249015 scopus 로고
    • Bone cell cilia: Vestigial or functional organelles?
    • Federman, M., Nichols, G.: Bone cell cilia: vestigial or functional organelles? Calcif. Tissue Res. 17(1), 81–85 (1974)
    • (1974) Calcif. Tissue Res. , vol.17 , Issue.1 , pp. 81-85
    • Federman, M.1    Nichols, G.2
  • 15
    • 0030058586 scopus 로고    scopus 로고
    • Flexural rigidity of microtubules measured with the use of optical tweezers
    • Felgner, H., Frank, R., Schliwa, M.: Flexural rigidity of microtubules measured with the use of optical tweezers. J. Cell Sci. 109(2), 509–516 (1996)
    • (1996) J. Cell Sci. , vol.109 , Issue.2 , pp. 509-516
    • Felgner, H.1    Frank, R.2    Schliwa, M.3
  • 16
    • 0142073812 scopus 로고    scopus 로고
    • Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
    • Gattone, V.H., Wang, X., Harris, P.C., Torres, V.E.: Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat. Med. 9(10), 1323–1326 (2003)
    • (2003) Nat. Med. , vol.9 , Issue.10 , pp. 1323-1326
    • Gattone, V.H.1    Wang, X.2    Harris, P.C.3    Torres, V.E.4
  • 20
    • 0030777556 scopus 로고    scopus 로고
    • Development of striated rootlets during ciliogenesis in the human oviduct epithelium
    • Hagiwara, H., Aoki, T., Ohwada, N., Fujimoto, T.: Development of striated rootlets during ciliogenesis in the human oviduct epithelium. Cell Tissue Res. 290(1), 39–42 (1997)
    • (1997) Cell Tissue Res , vol.290 , Issue.1 , pp. 39-42
    • Hagiwara, H.1    Aoki, T.2    Ohwada, N.3    Fujimoto, T.4
  • 21
    • 0036212052 scopus 로고    scopus 로고
    • Ultrastructural and immunohistochemical study of the basal apparatus of solitary cilia in the human oviduct epithelium
    • Hagiwara, H., Harada, S., Maeda, S., Aoki, T., Ohwada, N., Takata, K.: Ultrastructural and immunohistochemical study of the basal apparatus of solitary cilia in the human oviduct epithelium. J. Anat. 200(1), 89–96 (2002)
    • (2002) J. Anat. , vol.200 , Issue.1 , pp. 89-96
    • Hagiwara, H.1    Harada, S.2    Maeda, S.3    Aoki, T.4    Ohwada, N.5    Takata, K.6
  • 24
    • 0034987372 scopus 로고    scopus 로고
    • The C. Elegans homolog of the murine cystic kidney disease gene tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms
    • Haycraft, C.J., Swoboda, P., Taulman, P.D., Thomas, J.H., Yoder, B.K.: The C. elegans homolog of the murine cystic kidney disease gene tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 128, 1493–1505 (2001)
    • (2001) Development , vol.128 , pp. 1493-1505
    • Haycraft, C.J.1    Swoboda, P.2    Taulman, P.D.3    Thomas, J.H.4    Yoder, B.K.5
  • 27
    • 0021363853 scopus 로고
    • The ciliary basal apparatus is adapted to the structure and mechanics of the epithelium
    • Holley, M.C.: The ciliary basal apparatus is adapted to the structure and mechanics of the epithelium. Tissue Cell 16(2), 287–310 (1984)
    • (1984) Tissue Cell , vol.16 , Issue.2 , pp. 287-310
    • Holley, M.C.1
  • 29
    • 0347477365 scopus 로고    scopus 로고
    • Mechanobiology and diseases of mechanotransduction
    • Ingber, D.E.: Mechanobiology and diseases of mechanotransduction. Ann. Med. 35(8), 564–577 (2003)
    • (2003) Ann. Med. , vol.35 , Issue.8 , pp. 564-577
    • Ingber, D.E.1
  • 30
    • 1642390921 scopus 로고    scopus 로고
    • Primary cilia of human endothelial cells disassemble under laminar shear stress
    • Iomini, C., Tejada, K., Mo, W., Vaananen, H., Piperno, G.: Primary cilia of human endothelial cells disassemble under laminar shear stress. J. Cell Biol. 164(6), 811–817 (2004)
    • (2004) J. Cell Biol. , vol.164 , Issue.6 , pp. 811-817
    • Iomini, C.1    Tejada, K.2    Mo, W.3    Vaananen, H.4    Piperno, G.5
  • 33
    • 0023790936 scopus 로고
    • Cytoskeletal architecture and immunocytochemical localization of fodrin in the terminal web of the ciliated epithelial cell
    • Kobayashi, N., Hirokawa, N.: Cytoskeletal architecture and immunocytochemical localization of fodrin in the terminal web of the ciliated epithelial cell. Cell Motil. Cytoskelet. 11(3), 167–177 (1988)
    • (1988) Cell Motil. Cytoskelet. , vol.11 , Issue.3 , pp. 167-177
    • Kobayashi, N.1    Hirokawa, N.2
  • 36
    • 78651514374 scopus 로고    scopus 로고
    • Quantification of lacunar-canalicular fluid flow through computational modeling of fluorescence recovery after photobleaching
    • Kwon, R.Y., Frangos, J.A.: Quantification of lacunar-canalicular fluid flow through computational modeling of fluorescence recovery after photobleaching. Cell. Mol. Bioeng. doi:10.1007/s12195-010-0129-8 (2010)
    • (2010) Cell. Mol. Bioeng.
    • Kwon, R.Y.1    Frangos, J.A.2
  • 37
    • 77955732833 scopus 로고    scopus 로고
    • Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice
    • Kwon, R.Y., Meays, D.R., Tang, W.J., Frangos, J.A.: Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice. J. Bone Miner. Res. doi:10.1002/jbmr.74 (2010)
    • (2010) J. Bone Miner. Res.
    • Kwon, R.Y.1    Meays, D.R.2    Tang, W.J.3    Frangos, J.A.4
  • 38
    • 77955799439 scopus 로고    scopus 로고
    • Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic amp in bone cells
    • Kwon, R.Y., Temiyasathit, S., Tummala, P., Quah, C.C., Jacobs, C.R.: Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic amp in bone cells. FASEB J. 24(8), 2859–2868 (2010)
    • (2010) FASEB J , vol.24 , Issue.8 , pp. 2859-2868
    • Kwon, R.Y.1    Temiyasathit, S.2    Tummala, P.3    Quah, C.C.4    Jacobs, C.R.5
  • 39
    • 18244420973 scopus 로고
    • Characterization of antibodies as probes for structural and biochemical studies of tektins from ciliary and flagellar microtubules
    • Linck, R.W., Goggin, M.J., Norrander, J.M., Steffen, W.: Characterization of antibodies as probes for structural and biochemical studies of tektins from ciliary and flagellar microtubules. J. Cell Sci. 88(4), 453–466 (1987)
    • (1987) J. Cell Sci. , vol.88 , Issue.4 , pp. 453-466
    • Linck, R.W.1    Goggin, M.J.2    Norrander, J.M.3    Steffen, W.4
  • 41
    • 29744470060 scopus 로고    scopus 로고
    • Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease
    • Low, S.H., Vasanth, S., Larson, C.H., Mukherjee, S., Sharma, N., Kinter, M.T., Kane, M.E., Obara, T., Weimbs, T.: Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev. Cell 10, 57–69 (2006)
    • (2006) Dev. Cell , vol.10 , pp. 57-69
    • Low, S.H.1    Vasanth, S.2    Larson, C.H.3    Mukherjee, S.4    Sharma, N.5    Kinter, M.T.6    Kane, M.E.7    Obara, T.8    Weimbs, T.9
  • 43
    • 0033609103 scopus 로고    scopus 로고
    • Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
    • Marszalek, J.R., Ruiz-Lozano, P., Roberts, E., Chien, K.R., Goldstein, L.S.: Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. USA 96(9), 5043–5048 (1999)
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.9 , pp. 5043-5048
    • Marszalek, J.R.1    Ruiz-Lozano, P.2    Roberts, E.3    Chien, K.R.4    Goldstein, L.S.5
  • 44
    • 49449094484 scopus 로고    scopus 로고
    • Cholangiocyte primary cilia in liver health and disease
    • Masyuk, A.I., Masyuk, T.V., LaRusso, N.F.: Cholangiocyte primary cilia in liver health and disease. Dev. Dyn. 237(8), 2007–2012 (2008)
    • (2008) Dev. Dyn. , vol.237 , Issue.8 , pp. 2007-2012
    • Masyuk, A.I.1    Masyuk, T.V.2    Larusso, N.F.3
  • 46
    • 0038784537 scopus 로고    scopus 로고
    • Two populations of node monocilia initiate left–right asymmetry in the mouse
    • McGrath, J., Somlo, S., Makova, S., Tian, X., Brueckner, M.: Two populations of node monocilia initiate left–right asymmetry in the mouse. Cell 114(1), 61–73 (2003)
    • (2003) Cell , vol.114 , Issue.1 , pp. 61-73
    • McGrath, J.1    Somlo, S.2    Makova, S.3    Tian, X.4    Brueckner, M.5
  • 47
    • 0034042763 scopus 로고    scopus 로고
    • The Oak Ridge Polycystic Kidney (Orpk) disease gene is required for left–right axis determination
    • Murcia, N.S., Richards, W.G., Yoder, B.K., Mucenski, M.L., Dunlap, J.R., Woychik, R.P.: The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left–right axis determination. Development 127(11), 2347–2355 (2000)
    • (2000) Development , vol.127 , Issue.11 , pp. 2347-2355
    • Murcia, N.S.1    Richards, W.G.2    Yoder, B.K.3    Mucenski, M.L.4    Dunlap, J.R.5    Woychik, R.P.6
  • 49
    • 39849099174 scopus 로고    scopus 로고
    • Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1
    • Nauli, S.M., Kawanabe, Y., Kaminski, J.J., Pearce, W.J., Ingber, D.E., Zhou, J.: Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117(9), 1161–1171 (2008)
    • (2008) Circulation , vol.117 , Issue.9 , pp. 1161-1171
    • Nauli, S.M.1    Kawanabe, Y.2    Kaminski, J.J.3    Pearce, W.J.4    Ingber, D.E.5    Zhou, J.6
  • 50
    • 4344672618 scopus 로고    scopus 로고
    • Polycystins and mechanosensation in renal and nodal cilia
    • Nauli, S.M., Zhou, J.: Polycystins and mechanosensation in renal and nodal cilia. Bio Essays 26(8), 844–856 (2004)
    • (2004) Bio Essays , vol.26 , Issue.8 , pp. 844-856
    • Nauli, S.M.1    Zhou, J.2
  • 51
    • 0037019287 scopus 로고    scopus 로고
    • Determination of left–right patterning of the mouse embryo by artificial nodal flow
    • Nonaka, S., Shiratori, H., Saijoh, Y., Hamada, H.: Determination of left–right patterning of the mouse embryo by artificial nodal flow. Nature 418(6893), 96–99 (2002)
    • (2002) Nature , vol.418 , Issue.6893 , pp. 96-99
    • Nonaka, S.1    Shiratori, H.2    Saijoh, Y.3    Hamada, H.4
  • 52
    • 0032428685 scopus 로고    scopus 로고
    • Randomization of left–right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
    • Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M., Hirokawa, N.: Randomization of left–right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95(6):829–837 (1998)
    • (1998) Cell , vol.95 , Issue.6 , pp. 829-837
    • Nonaka, S.1    Tanaka, Y.2    Okada, Y.3    Takeda, S.4    Harada, A.5    Kanai, Y.6    Kido, M.7    Hirokawa, N.8
  • 53
    • 0022352165 scopus 로고
    • Observations on the solitary cilium of rabbit oviductal epithelium: Its motility and ultrastructure
    • Odor, D.L., Blandau, R.J.: Observations on the solitary cilium of rabbit oviductal epithelium: its motility and ultrastructure. Am. J. Anat. 174(4), 437–453 (1985)
    • (1985) Am. J. Anat. , vol.174 , Issue.4 , pp. 437-453
    • Odor, D.L.1    Blandau, R.J.2
  • 54
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mutant mice with polycystic kidney disease
    • Pazour, G.J., San Agustin, J.T., Follit, J.A., Rosenbaum, J.L., Witman, G.B.: Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mutant mice with polycystic kidney disease. Curr. Biol. 12(11), R378–R380 (2002)
    • (2002) Curr. Biol. , vol.12 , Issue.11 , pp. R378-R380
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3    Rosenbaum, J.L.4    Witman, G.B.5
  • 55
    • 0031777851 scopus 로고    scopus 로고
    • A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)
    • Pazour, G.J., Wilkerson, C.G., Witman, G.B.: A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J. Cell Biol. 141(4), 979–992 (1998)
    • (1998) J. Cell Biol. , vol.141 , Issue.4 , pp. 979-992
    • Pazour, G.J.1    Wilkerson, C.G.2    Witman, G.B.3
  • 56
    • 0037018850 scopus 로고    scopus 로고
    • The ion channel polycystin-2 is required for left–right axis determination in mice
    • Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A., Skryabin, B.: The ion channel polycystin-2 is required for left–right axis determination in mice. Curr. Biol. 12(11), 938–943 (2002)
    • (2002) Curr. Biol. , vol.12 , Issue.11 , pp. 938-943
    • Pennekamp, P.1    Karcher, C.2    Fischer, A.3    Schweickert, A.4    Skryabin, B.5
  • 57
    • 0017654342 scopus 로고
    • Transport mechanism operating between blood supply and osteocytes in long bones
    • Piekarski, K., Munro, M.: Transport mechanism operating between blood supply and osteocytes in long bones. Nature 269(5623), 80–82 (1977)
    • (1977) Nature , vol.269 , Issue.5623 , pp. 80-82
    • Piekarski, K.1    Munro, M.2
  • 59
    • 0035498717 scopus 로고    scopus 로고
    • Bending the MDCK cell primary cilium increases intracellular calcium
    • Praetorius, H.A., Spring, K.R.: Bending the MDCK cell primary cilium increases intracellular calcium. J. Membr. Biol. 184(1), 71–79 (2001)
    • (2001) J. Membr. Biol. , vol.184 , Issue.1 , pp. 71-79
    • Praetorius, H.A.1    Spring, K.R.2
  • 60
    • 0037557518 scopus 로고    scopus 로고
    • Removal of the MDCK cell primary cilium abolishes flow sensing
    • Praetorius, H.A., Spring, K.R.: Removal of the MDCK cell primary cilium abolishes flow sensing. J. Membr. Biol. 191(1), 69–76 (2003)
    • (2003) J. Membr. Biol. , vol.191 , Issue.1 , pp. 69-76
    • Praetorius, H.A.1    Spring, K.R.2
  • 61
    • 15544367400 scopus 로고    scopus 로고
    • A physiological view of the primary cilium
    • Praetorius, H.A., Spring, K.R.: A physiological view of the primary cilium. Annu. Rev. Physiol. 67, 515–529 (2005)
    • (2005) Annu. Rev. Physiol. , vol.67 , pp. 515-529
    • Praetorius, H.A.1    Spring, K.R.2
  • 62
    • 60349093994 scopus 로고    scopus 로고
    • Ciliary ion channels: Location, location, location
    • Quarmby, L.: Ciliary ion channels: location, location, location. Curr. Biol. 19(4), R158–R160 (2009)
    • (2009) Curr. Biol. , vol.19 , Issue.4 , pp. R158-R160
    • Quarmby, L.1
  • 63
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi, R., Milenkovic, L., Scott, M.P.: Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836), 372–376 (2007)
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 66
    • 18144444613 scopus 로고
    • Flexible substratum technique for viewing cells from the side: Some in vivo properties of primary (9+0) cilia in cultured kidney epithelia
    • Pt. 4
    • Roth, K.E., Rieder, C.L., Bowser, S.S.: Flexible substratum technique for viewing cells from the side: some in vivo properties of primary (9+0) cilia in cultured kidney epithelia. J. Cell Sci. 89(Pt. 4), 457–466 (1988)
    • (1988) J. Cell Sci. , vol.89 , pp. 457-466
    • Roth, K.E.1    Rieder, C.L.2    Bowser, S.S.3
  • 70
    • 0030845225 scopus 로고    scopus 로고
    • Analysis and modeling of the primary cilium bending response to fluid shear
    • Schwartz, E.A., Leonard, M.L., Bizios, R., Bowser, S.S.: Analysis and modeling of the primary cilium bending response to fluid shear. Am. J. Physiol. Renal Physiol. 272(41), F132–F138 (1997)
    • (1997) Am. J. Physiol. Renal Physiol. , vol.272 , Issue.41 , pp. F132-F138
    • Schwartz, E.A.1    Leonard, M.L.2    Bizios, R.3    Bowser, S.S.4
  • 72
    • 0035499874 scopus 로고    scopus 로고
    • Polycystin channels and kidney disease
    • Stayner, C., Zhou, J.: Polycystin channels and kidney disease. Trends Pharmacol. Sci. 22(11), 543–546 (2001)
    • (2001) Trends Pharmacol. Sci. , vol.22 , Issue.11 , pp. 543-546
    • Stayner, C.1    Zhou, J.2
  • 73
    • 52449085471 scopus 로고    scopus 로고
    • Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice
    • Sugiyama, T., Saxon, L.K., Zaman, G., Moustafa, A., Sunters, A., Price, J.S., Lanyon, L.E.: Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice. Bone 43(2), 238–248 (2008)
    • (2008) Bone , vol.43 , Issue.2 , pp. 238-248
    • Sugiyama, T.1    Saxon, L.K.2    Zaman, G.3    Moustafa, A.4    Sunters, A.5    Price, J.S.6    Lanyon, L.E.7
  • 74
    • 33747088253 scopus 로고    scopus 로고
    • Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography
    • Sui, H., Downing, K.H.: Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography. Nature 442(7101), 475–478 (2006)
    • (2006) Nature , vol.442 , Issue.7101 , pp. 475-478
    • Sui, H.1    Downing, K.H.2
  • 75
    • 0027102583 scopus 로고
    • Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins
    • Takemura, R., Okabe, S., Umeyama, T., Kanai, Y., Cowan, N.J., Hirokawa, N.: Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins. J. Cell Sci. 103(4), 953–964 (1992)
    • (1992) J. Cell Sci. , vol.103 , Issue.4 , pp. 953-964
    • Takemura, R.1    Okabe, S.2    Umeyama, T.3    Kanai, Y.4    Cowan, N.J.5    Hirokawa, N.6
  • 76
    • 0035159015 scopus 로고    scopus 로고
    • Polaris, a protein involved in left–right axis patterning, localizes to basal bodies and cilia
    • Taulman, P.D., Haycraft, C.J., Balkovetz, D.F., Yoder, B.K.: Polaris, a protein involved in left–right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 12(3), 589–599 (2001)
    • (2001) Mol. Biol. Cell , vol.12 , Issue.3 , pp. 589-599
    • Taulman, P.D.1    Haycraft, C.J.2    Balkovetz, D.F.3    Yoder, B.K.4
  • 80
    • 0037959910 scopus 로고    scopus 로고
    • The left–right determinant inversin is a component of node monocilia and other 9+0 cilia
    • Watanabe, D., Saijoh, Y., Nonaka, S., Sasaki, G., Ikawa, Y., Yokoyama, T., Hamada, H.: The left–right determinant inversin is a component of node monocilia and other 9+0 cilia. Development 130(9), 1725–1734 (2003)
    • (2003) Development , vol.130 , Issue.9 , pp. 1725-1734
    • Watanabe, D.1    Saijoh, Y.2    Nonaka, S.3    Sasaki, G.4    Ikawa, Y.5    Yokoyama, T.6    Hamada, H.7
  • 81
    • 0028386524 scopus 로고
    • A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
    • Weinbaum, S., Cowin, S.C., Zeng, Y.: A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 27(3), 339–360 (1994)
    • (1994) J. Biomech. , vol.27 , Issue.3 , pp. 339-360
    • Weinbaum, S.1    Cowin, S.C.2    Zeng, Y.3
  • 82
    • 0345169048 scopus 로고    scopus 로고
    • Post-translational modifications regulate microtubule function
    • Westermann, S., Weber, K.: Post-translational modifications regulate microtubule function. Nat. Rev. Mol. Cell Biol. 4(12), 938–947 (2003)
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , Issue.12 , pp. 938-947
    • Westermann, S.1    Weber, K.2
  • 83
    • 34547585202 scopus 로고    scopus 로고
    • The shear stress of it all: The cell membrane and mechanochemical transduction
    • White, C.R., Frangos, J.A.: The shear stress of it all: The cell membrane and mechanochemical transduction. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 362(1484), 1459–1467 (2007)
    • (2007) Philos. Trans. R. Soc. Lond. B. Biol. Sci. , vol.362 , Issue.1484 , pp. 1459-1467
    • White, C.R.1    Frangos, J.A.2
  • 85
    • 45549101592 scopus 로고    scopus 로고
    • Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor runx2-ii
    • Xiao, Z., Zhang, S., Magenheimer, B.S., Luo, J., Quarles, D.: Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor runx2-ii. J. Biol. Chem. 283(18), 12624–12634 (2008)
    • (2008) J. Biol. Chem. , vol.283 , Issue.18 , pp. 12624-12634
    • Xiao, Z.1    Zhang, S.2    Magenheimer, B.S.3    Luo, J.4    Quarles, D.5
  • 87
    • 0022981756 scopus 로고
    • Electron microscopic observation of the primary cilium in the pancreatic islets
    • Yamamoto, M., Kataoka, K.: Electron microscopic observation of the primary cilium in the pancreatic islets. Arch. Histol. Jap. 49(4), 449–457 (1986)
    • (1986) Arch. Histol. Jap. , vol.49 , Issue.4 , pp. 449-457
    • Yamamoto, M.1    Kataoka, K.2
  • 88
    • 34248151938 scopus 로고    scopus 로고
    • Role of primary cilia in the pathogenesis of polycystic kidney disease
    • Yoder, B.K.: Role of primary cilia in the pathogenesis of polycystic kidney disease. J. Am. Soc. Nephrol. 18(5), 1381–1388 (2007)
    • (2007) J. Am. Soc. Nephrol. , vol.18 , Issue.5 , pp. 1381-1388
    • Yoder, B.K.1
  • 89
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1 and polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder, B.K., Hou, X., Guay-Woodford, L.M.: 2002) The polycystic kidney disease proteins, polycystin-1 and polycystin-2, polaris, and cystin, are co-localized in renal cilia. J. Am. Soc. Nephrol. 13(10), 2508–2516.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , Issue.10 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3
  • 91
    • 0035918140 scopus 로고    scopus 로고
    • Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts
    • You, J., Reilly, G.C., Zhen, X., Yellowley, C.E., Chen, Q., Donahue, H.J., Jacobs, C.R.: Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J. Biol. Chem. 276(16), 13365–13371 (2001)
    • (2001) J. Biol. Chem. , vol.276 , Issue.16 , pp. 13365-13371
    • You, J.1    Reilly, G.C.2    Zhen, X.3    Yellowley, C.E.4    Chen, Q.5    Donahue, H.J.6    Jacobs, C.R.7
  • 92
    • 0028048167 scopus 로고
    • A fiber-matrix model for fluid-flow and streaming potentials in the canaliculi of an osteon
    • Zeng, Y., Cowin, S.C., Weinbaum, S.: A fiber-matrix model for fluid-flow and streaming potentials in the canaliculi of an osteon. Ann. Biomed. Eng. 22(3), 280–292 (1994)
    • (1994) Ann. Biomed. Eng. , vol.22 , Issue.3 , pp. 280-292
    • Zeng, Y.1    Cowin, S.C.2    Weinbaum, S.3


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