T cells, murine chronic graft-versus-host disease and autoimmunity

Journal of Autoimmunity

Volumn 39, Issue 3, 2012, Pages 240-247

  Eisenberg, Robert A ^a   Via, Charles S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

CD4 T cells; CD8 T cells; Chronic GVHD; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOIMMUNITY; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CYTOTOXICITY; DISEASE SEVERITY; DOWN REGULATION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOPATHOLOGY; MEMORY T LYMPHOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; DISEASE MODELS, ANIMAL; FEMALE; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; SEX FACTORS; TISSUE DONORS;

EID: 84865356890     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.05.017     Document Type: Review

References (76)

1. Eisenberg R. Mechanisms of autoimmunity. Immunol Res 2003, 27:203-218.
2. Howie J.B., Helyer B.J. The immunology and pathology of NZB mice. Adv Immunol 1968, 9:215-266.
3. Borchers A., Ansari A.A., Hsu T., Kono D.H., Gershwin M.E. The pathogenesis of autoimmunity in New Zealand mice. Semin Arthritis Rheum 2000, 29:385-399.
4. Kono D.H., Theofilopoulos A.N. Genetics of SLE in mice. Springer Semin Immunopathol 2006, 28:83-96.
5. Maldonado M.A., Kakkanaiah V., MacDonald G.C., Chen F., Reap E.A., Balish E., et al. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J Immunol 1999, 162:6322-6330.
6. Cheung Y.H., Loh C., Pau E., Kim J., Wither J. Insights into the genetic basis and immunopathogenesis of systemic lupus erythematosus from the study of mouse models. Semin Immunol 2009, 21:372-382.
7. Morel L. Genetics of SLE: evidence from mouse models. Nat Rev Rheumatol 2010, 6:348-357.
8. Shlomchik M., Mascelli M., Shan H., Radic M.Z., Pisetsky D., Marshak-Rothstein A., et al. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med 1990, 171:265-292.
9. Yount W.J., Cohen P., Eisenberg R.A. Distribution of IgG subclasses among human autoantibodies to Sm, RNP, dsDNA, SS-B and IgG rheumatoid factor. Monogr Allergy 1988, 23:41-56.
10. Sobel E.S., Katagiri T., Katagiri K., Morris S.C., Cohen P.L., Eisenberg R.A. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J Exp Med 1991, 173:1441-1449.
11. Sobel E.S., Cohen P.L., Eisenberg R.A. Lpr T cells are necessary for autoantibody production in lpr mice. J Immunol 1993, 150:4160-4167.
12. Lu L., Kaliyaperumal A., Boumpas D.T., Datta S.K. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J Clin Invest 1999, 104:345-355.
13. Via C.S. Advances in lupus stemming from the parent-into-F1 model. Trends Immunol 2010, 31:236-245.
14. Eisenberg R.A. The chronic graft-versus-host model of systemic autoimmunity. B cell biology in autoimmunity 2002, 228-243. Karger, Basel. D. Nemazee (Ed.).
15. Blazar B.R., Murphy W.J., Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol 2012.
16. Sarkar K., Miller F.W. Possible roles and determinants of microchimerism in autoimmune and other disorders. Autoimmun Rev 2004, 3:454-463.
17. Kremer Hovinga I.C., Koopmans M., de Heer E., Bruijn J.A., Bajema I.M. Chimerism in systemic lupus erythematosus-three hypotheses. Rheumatology (Oxford) 2007, 46:200-208.
18. Stevens A.M. Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?. Lupus 2006, 15:820-826.
19. Eisenberg R.A., Cohen P.L. Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus. Clin Immunol Immunopathol 1983, 29:1-6.
20. Sekiguchi D.R., Jainandunsing S.M., Fields M.L., Maldonado M.A., Madaio M.P., Erikson J., et al. Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cells. J Immunol 2002, 168:4142-4153.
21. Sekiguchi D.R., Eisenberg R.A., Weigert M. Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells. J Exp Med 2003, 197:27-39.
22. Rolink A.G., Gleichmann E. Allosuppressor- and allohelper-T cells in acute and chronic graft-vs.-host (GVH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndromes. J Exp Med 1983, 158:546-558.
23. Rolink A.G., Pals S.T., Gleichmann E. Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A. J Exp Med 1983, 157:755-771.
24. Via C.S., Sharrow S.O., Shearer G.M. Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease. J Immunol 1987, 139:1840-1849.
25. Bradley D.S., Jennette J.C., Cohen P.L., Eisenberg R.A. Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J Immunol 1994, 152:1960-1969.
26. Lafuse W.P., McCormick J.F., Melvold R.W., David C.S. Serological and biochemical analysis of Ia molecules in the I-A mutant B6.C-H-2. Transplantation 1981, 31:434-438.
27. Tse H.Y., Kanamori S., Walsh W.D., Hansen T.H. The murine bm12 gene conversion provides evidence that T cells recognize predominantly Ia conformation. Proc Natl Acad Sci U S A 1985, 82:7058-7062.
28. Portanova J.P., Ebling F.M., Hammond W.S., Hahn B.H., Kotzin B.L. Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease. J Immunol 1988, 141:3370-3376.
29. Morris S.C., Cheek R.L., Cohen P.L., Eisenberg R.A. Autoantibodies in chronic graft versus host result from cognate T-B interactions. J Exp Med 1990, 171:503-517.
30. Busser B.W., Adair B.S., Erikson J., Laufer T.M. Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance. J Clin Invest 2003, 112:1361-1371.
31. Rozendaal L., Pals S.T., Gleichmann E., Melief C.J. Persistence of allospecific helper T cells is required for maintaining autoantibody formation in lupus-like graft-versus-host disease. Clin Exp Immunol 1990, 82:527-532.
32. Halpern M.D., Fisher C.L., Cohen P.L., Eisenberg R.A. Influence of the Ig H chain locus on autoantibody production in autoimmune mice. J Immunol 1992, 149:3735-3740.
33. Chen F., Maldonado M.A., Madaio M., Eisenberg R.A. The role of host (endogenous) T cells in chronic graft-versus-host autoimmune disease. J Immunol 1998, 161:5880-5885.
34. Choudhury A., Maldonado M.A., Cohen P.L., Eisenberg R.A. The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 2005, 174:7600-7609.
35. Tschetter J.R., Mozes E., Shearer G.M. Progression from acute to chronic disease in a murine parent-into-F1 model of graft-versus-host disease. J Immunol 2000, 165:5987-5994.
36. Puliaev R., Puliaeva I., Welniak L.A., Ryan A.E., Haas M., Murphy W.J., et al. CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus. J Immunol 2008, 181:47-61.
37. Puliaeva I., Puliaev R., Shustov A., Haas M., Via C.S. Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses. J Immunol 2008, 181:5912-5929.
38. Rus V., Svetic A., Nguyen P., Gause W.C., Via C.S. Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J Immunol 1995, 155:2396-2406.
39. Puliaev R., Nguyen P., Finkelman F.D., Via C.S. Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease. J Immunol 2004, 173:910-919.
40. Puliaeva I., Soloviova K., Puliaiev M., Lang T., Puliaev R., Via C.S. Enhancement of suboptimal CD8 cytotoxic T cell effector function in vivo using antigen-specific CD80 defective T cells. J Immunol 2011, 186:291-304.
41. Shustov A., Nguyen P., Finkelman F., Elkon K.B., Via C.S. Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease: up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production. J Immunol 1998, 161:2848-2855.
42. Shortman K., Heath W.R. The CD8+ dendritic cell subset. Immunol Rev 2010, 234:18-31.
43. Puliaeva I., Puliaev R., Via C.S. Therapeutic potential of CD8+ cytotoxic T lymphocytes in SLE. Autoimmun Rev 2009, 8:219-223.
44. Grader-Beck T., Casciola-Rosen L., Lang T.J., Puliaev R., Rosen A., Via C.S. Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) polymerase 1 in a murine model of lupus. J Immunol 2007, 178:95-102.
45. Foster A.D., Haas M., Puliaeva I., Soloviova K., Puliaev R., Via C.S. Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression. Clin Immunol 2010, 136:61-73.
46. Foster A.D., Soloviova K., Puliaeva I., Puliaiev M., Puliaev R., Finkelman F., et al. Donor CD8 T cells and IFN-gamma are critical for sex-based differences in donor CD4 T cell engraftment and lupus-like phenotype in short-term chronic graft-versus-host disease mice. J Immunol 2011, 186:6238-6254.
47. Spaner D., Raju K., Rabinovich B., Miller R.G. A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J Immunol 1999, 162:1192-1199.
48. Spaner D., Raju K., Radvanyi L., Lin Y., Miller R.G. A role for perforin in activation-induced cell death. J Immunol 1998, 160:2655-2664.
49. Kosmatopoulos K., Scott-Algara D., Orbach-Arbouys S., Halle-Pannenko O. Specific resistance to local graft-versus-host reaction in F1 hybrids pretreated intravenously with parent-strain spleen cells. Role of cytotoxic T lymphocytes directed against receptors for the major histocompatibility complex. Transplantation 1988, 46:570-574.
50. Niculescu F., Niculescu T., Nguyen P., Puliaev R., Papadimitriou J.C., Gaspari A., et al. Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease. Exp Mol Pathol 2005, 79:136-145.
51. Hadley G.A., Bartlett S.T., Via C.S., Rostapshova E.A., Moainie S. The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL. J Immunol 1997, 159:3748-3756.
52. Hakim F.T., Sharrow S.O., Payne S., Shearer G.M. Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes. J Immunol 1991, 146:2108-2115.
53. Shustov A., Luzina I., Nguyen P., Papadimitriou J.C., Handwerger B., Elkon K.B., et al. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J Clin Invest 2000, 106:R39-R47.
54. Shedlock D.J., Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003, 300:337-339.
55. Harty J.T., Badovinac V.P. Shaping and reshaping CD8+ T-cell memory. Nat Rev Immunol 2008, 8:107-119.
56. Janssen E.M., Lemmens E.E., Wolfe T., Christen U., von Herrath M.G., Schoenberger S.P. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 2003, 421:852-856.
57. Morris S.C., Cohen P.L., Eisenberg R.A. Experimental induction of systemic lupus erythematosus by recognition of foreign Ia. Clin Immunol Immunopathol 1990, 57:263-273.
58. Lang T.J., Nguyen P., Papadimitriou J.C., Via C.S. Increased severity of murine lupus in female mice is due to enhanced expansion of pathogenic T cells. J Immunol 2003, 171:5795-5801.
59. Oritani K., Kincade P.W., Zhang C., Tomiyama Y., Matsuzawa Y. Type I interferons and limitin: a comparison of structures, receptors, and functions. Cytokine Growth Factor Rev 2001, 12:337-348.
60. Leonard W.J., Zeng R., Spolski R. Interleukin 21: a cytokine/cytokine receptor system that has come of age. J Leukoc Biol 2008, 84:348-356.
61. Kim J., Kim H.J., Choi W.S., Nam S.H., Cho H.R., Kwon B. Maintenance of CD8+ T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease. Exp Mol Med 2006, 38:494-501.
62. Zheng S.G., Wang J.H., Koss M.N., Quismorio F., Gray J.D., Horwitz D.A. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 2004, 172:1531-1539.
63. Vugmeyster Y., Guay H., Szklut P., Qian M.D., Jin M., Widom A., et al. In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus. MAbs 2010, 2:335-346.
64. Lichtman E.I., Helfgott S.M., Kriegel M.A. Emerging therapies for systemic lupus erythematosus - focus on targeting interferon-alpha. Clin Immunol 2012.
65. Goldman M., Druet P., Gleichmann E. TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol Today 1991, 12:223-227.
66. Goldman M., Feng H.M., Engers H., Hochman A., Louis J., Lambert P.H. Autoimmunity and immune complex disease after neonatal induction of transplantation tolerance in mice. J Immunol 1983, 131:251-258.
67. Reeves W.H., Lee P.Y., Weinstein J.S., Satoh M., Lu L. Induction of autoimmunity by pristane and other naturally occurring hydrocarbons. Trends Immunol 2009, 30:455-464.
68. Eisenberg R.A., Pisetsky D., Cohen P.L. Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. Clin Immunol Immunopathol 1985, 35:337-345.
69. Satoh M., Richards H.B., Shaheen V.M., Yoshida H., Shaw M., Naim J.O., et al. Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane. Clin Exp Immunol 2000, 121:399-405.
70. Silbergeld E.K., Silva I.A., Nyland J.F. Mercury and autoimmunity: implications for occupational and environmental health. Toxicol Appl Pharmacol 2005, 207:282-292.
71. Bigazzi P.E. Autoimmunity and heavy metals. Lupus 1994, 3:449-453.
72. Reuter R., Tessars G., Vohr H.W., Gleichmann E., Luhrmann R. Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Proc Natl Acad Sci U S A 1989, 86:237-241.
73. Rowley B., Monestier M. Mechanisms of heavy metal-induced autoimmunity. Mol Immunol 2005, 42:833-838.
74. s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity. Eur J Immunol 1994, 24:723-730.
75. Robinson C.J., Balazs T., Egorov I.K. Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice. Toxicol Appl Pharmacol 1986, 86:159-169.
76. Pals S.T., Radaszkiewicz T., Roozendaal L., Gleichmann E. Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction. J Immunol 1985, 134:1475-1482.