Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides

Journal of Chromatography A

Volumn 1255, Issue , 2012, Pages 237-243

  Li, Qin ^a,b   Lynen, Frédéric ^a   Wang, Jian ^c   Li, Hanlin ^c   Xu, Guowang ^b   Sandra, Pat ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c PFIZER INC   (United States)

Author keywords

Comprehensive two dimensional liquid chromatography; Hydrophilic interaction liquid chromatography; Ion pair reversed phase liquid chromatography; LC LC interface; Oligonucleotides

Indexed keywords

CHROMATOGRAPHIC PEAKS; COMPREHENSIVE TWO-DIMENSIONAL; COMPREHENSIVE TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; HYDROPHILIC INTERACTION; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; ION PAIRS; IONIZATION MODES; IP-RPLC; OCTADECYL SILICA; ORTHOGONALITY; REVERSED-PHASE LIQUID CHROMATOGRAPHY; TRIETHYLAMINES; TWO-DIMENSION;

IONS; MASS SPECTROMETRY; OLIGONUCLEOTIDES; SILICA; TWO DIMENSIONAL;

LIQUID CHROMATOGRAPHY;

BUFFER; OLIGONUCLEOTIDE; TRIETHYLAMINE ACETATE; UNCLASSIFIED DRUG; WATER;

ANALYTIC METHOD; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IMMOBILIZATION; ION PAIR CHROMATOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; VOLATILIZATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; ETHYLAMINES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; OLIGONUCLEOTIDES; REPRODUCIBILITY OF RESULTS;

EID: 84865354880     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.11.062     Document Type: Article

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