Combining ion pairing agents for enhanced analysis of oligonucleotide therapeutics by reversed phase-ion pairing ultra performance liquid chromatography (UPLC)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 19, 2011, Pages 1587-1595

  Levin, Daren S ^a   Shepperd, Benjamin T ^a   Gruenloh, Christopher J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Ion pairing; Oligonucleotide; Purity; Reversed phase; SiRNA; UPLC

Indexed keywords

ION-PAIRING; PURITY; REVERSED-PHASE; SIRNA; UPLC;

BIOPOLYMERS; IONIC LIQUIDS; IONS; LIQUID CHROMATOGRAPHY; MOBILE AGENTS; QUALITY CONTROL; RNA;

OLIGONUCLEOTIDES;

BIOPOLYMER; DNA; ION; LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; RNA;

ARTICLE; CONTROLLED STUDY; ISOMER; MACROMOLECULE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PURIFICATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; RNA INTERFERENCE; RNA SPLICING; SYNTHESIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; ETHYLAMINES; IONS; OLIGONUCLEOTIDES; PROPYLAMINES; RNA, SMALL INTERFERING;

EID: 79955884483     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.03.051     Document Type: Article

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