-
1
-
-
0016831976
-
Suppression of tumour growth in mice by a drug-antibody conjugate using a novel approach to linkage
-
Rowland GF, O'Neill GJ, Davies DA. Suppression of tumour growth in mice by a drug-antibody conjugate using a novel approach to linkage. Nature 1975;255:487-8
-
(1975)
Nature
, vol.255
, pp. 487-488
-
-
Rowland, G.F.1
O'Neill, G.J.2
Davies, D.A.3
-
2
-
-
15944365883
-
A review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies not four letter words
-
Mirick GR, Bradt BM, Denardo SJ, Denardo GL. A review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies. Not four letter words. Q J Nucl Med Mol Imaging 2004;48:251-7 (Pubitemid 43932934)
-
(2004)
Quarterly Journal of Nuclear Medicine and Molecular Imaging
, vol.48
, Issue.4
, pp. 251-257
-
-
Mirick, G.R.1
Bradt, B.M.2
Denardo, S.J.3
Denardo, G.L.4
-
3
-
-
78649642694
-
Have we overestimated the benefit of human(ized) antibodies?
-
Getts DR, Getts MT, McCarthy DP, et al. Have we overestimated the benefit of human(ized) antibodies? MAbs 2010;2:682-94
-
(2010)
MAbs
, vol.2
, pp. 682-694
-
-
Getts, D.R.1
Getts, M.T.2
McCarthy, D.P.3
-
4
-
-
77957338351
-
Mining human antibody repertoires
-
Beerli RR, Rader C. Mining human antibody repertoires. MAbs 2010;2:365-78
-
(2010)
MAbs
, vol.2
, pp. 365-378
-
-
Beerli, R.R.1
Rader, C.2
-
5
-
-
70350438004
-
The versatile MHC class I-related FcRn protects IgG and albumin from degradation: Implications for development of new diagnostics and therapeutics
-
Andersen JT, Sandlie I. The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics. Drug Metab Pharmacokinet 2009;24:318-32
-
(2009)
Drug Metab Pharmacokinet
, vol.24
, pp. 318-332
-
-
Andersen, J.T.1
Sandlie, I.2
-
6
-
-
78651340524
-
Neonatal Fc receptor: From immunity to therapeutics
-
Kuo TT, Baker K, Yoshida M, et al. Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol 2010;30:777-89
-
(2010)
J Clin Immunol
, vol.30
, pp. 777-789
-
-
Kuo, T.T.1
Baker, K.2
Yoshida, M.3
-
7
-
-
33746836894
-
Targeted therapy of cancer: New prospects for antibodies and immunoconjugates
-
Sharkey RM, Goldenberg DM. Targeted therapy of cancer: new prospects for antibodies and immunoconjugates. CA Cancer J Clin 2006;56:226-43 (Pubitemid 44175051)
-
(2006)
Ca-A Cancer Journal for Clinicians
, vol.56
, Issue.4
, pp. 226-243
-
-
Sharkey, R.M.1
Goldenberg, D.M.2
-
9
-
-
46849103828
-
Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
-
Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv Drug Deliv Rev 2008;60:1421-34
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 1421-1434
-
-
Thurber, G.M.1
Schmidt, M.M.2
Wittrup, K.D.3
-
10
-
-
70350234894
-
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
-
Schmidt MM, Wittrup KD. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Mol Cancer Ther 2009;8:2861-71
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2861-2871
-
-
Schmidt, M.M.1
Wittrup, K.D.2
-
11
-
-
76749132728
-
Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: Effects of affinity and molecular size
-
Zahnd C, Kawe M, Stumpp MT, et al. Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size. Cancer Res 2010;70:1595-605
-
(2010)
Cancer Res
, vol.70
, pp. 1595-1605
-
-
Zahnd, C.1
Kawe, M.2
Stumpp, M.T.3
-
12
-
-
38949192547
-
Targeted cancer therapy: Conferring specificity to cytotoxic drugs
-
Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res 2008;41:98-107
-
(2008)
Acc Chem Res
, vol.41
, pp. 98-107
-
-
Chari, R.V.1
-
13
-
-
79960820705
-
Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components
-
Dosio F, Brusa P, Cattel L. Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components. Toxins (Basel) 2011;3:848-83
-
(2011)
Toxins (Basel)
, vol.3
, pp. 848-883
-
-
Dosio, F.1
Brusa, P.2
Cattel, L.3
-
14
-
-
10744222473
-
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
-
DOI 10.1038/nbt832
-
Doronina SO, Toki BE, Torgov MY, et al. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol 2003;21:778-84 (Pubitemid 36791396)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.7
, pp. 778-784
-
-
Doronina, S.O.1
Toki, B.E.2
Torgov, M.Y.3
Mendelsohn, B.A.4
Cerveny, C.G.5
Chace, D.F.6
DeBlanc, R.L.7
Gearing, R.P.8
Bovee, T.D.9
Siegall, C.B.10
Francisco, J.A.11
Wahl, A.F.12
Meyer, D.L.13
Senter, P.D.14
-
15
-
-
31544441685
-
Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
-
DOI 10.1021/bc0502917
-
Doronina SO, Mendelsohn BA, Bovee TD, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem 2006;17:114-24 (Pubitemid 43157592)
-
(2006)
Bioconjugate Chemistry
, vol.17
, Issue.1
, pp. 114-124
-
-
Doronina, S.O.1
Mendelsohn, B.A.2
Bovee, T.D.3
Cerveny, C.G.4
Alley, S.C.5
Meyer, D.L.6
Oflazoglu, E.7
Toki, B.E.8
Sanderson, R.J.9
Zabinski, R.F.10
Wahl, A.F.11
Senter, P.D.12
-
16
-
-
33745847797
-
Semisynthetic Maytansine analogues for the targeted treatment of cancer
-
DOI 10.1021/jm060319f
-
Widdison WC, Wilhelm SD, Cavanagh EE, et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. J Med Chem 2006;49:4392-408 (Pubitemid 44036683)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.14
, pp. 4392-4408
-
-
Widdison, W.C.1
Wilhelm, S.D.2
Cavanagh, E.E.3
Whiteman, K.R.4
Leece, B.A.5
Kovtun, Y.6
Goldmacher, V.S.7
Xie, H.8
Steeves, R.M.9
Lutz, R.J.10
Zhao, R.11
Wang, L.12
Blattler, W.A.13
Chari, R.V.J.14
-
20
-
-
79955867207
-
The development of pyrrolobenzodiazepines as antitumour agents
-
Hartley JA. The development of pyrrolobenzodiazepines as antitumour agents. Expert Opin Investig Drugs 2011;20:733-44
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 733-744
-
-
Hartley, J.A.1
-
21
-
-
79957683054
-
Bispecific digoxigenin-binding antibodies for targeted payload delivery
-
Metz S, Haas AK, Daub K, et al. Bispecific digoxigenin-binding antibodies for targeted payload delivery. Proc Natl Acad Sci USA 2011;108:8194-9
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 8194-8199
-
-
Metz, S.1
Haas, A.K.2
Daub, K.3
-
22
-
-
0037124507
-
Enzymatic procedure for site-specific pegylation of proteins
-
DOI 10.1016/S0169-409X(02)00024-8, PII S0169409X02000248
-
Sato H. Enzymatic procedure for site-specific pegylation of proteins. Adv Drug Deliv Rev 2002;54:487-504 (Pubitemid 34615545)
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.4
, pp. 487-504
-
-
Sato, H.1
-
23
-
-
84555177672
-
SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells
-
Hussain AF, Kampmeier F, von Felbert V, et al. SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells. Bioconjug Chem 2011;22:2487-95
-
(2011)
Bioconjug Chem
, vol.22
, pp. 2487-2495
-
-
Hussain, A.F.1
Kampmeier, F.2
Von Felbert, V.3
-
24
-
-
77956637683
-
Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: Changes due to modification and conjugation processes
-
Wakankar AA, Feeney MB, Rivera J, et al. Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes. Bioconjug Chem 2010;21:1588-95
-
(2010)
Bioconjug Chem
, vol.21
, pp. 1588-1595
-
-
Wakankar, A.A.1
Feeney, M.B.2
Rivera, J.3
-
25
-
-
0035091343
-
Antibody-targeted immunotherapy for treatment of malignancy
-
DOI 10.1146/annurev.med.52.1.125
-
White CA, Weaver RL, Grillo-Lopez AJ. Antibody-targeted immunotherapy for treatment of malignancy. Annu Rev Med 2001;52:125-45 (Pubitemid 32197306)
-
(2001)
Annual Review of Medicine
, vol.52
, pp. 125-145
-
-
White, C.A.1
Weaver, R.L.2
Grillo-Lopez, A.J.3
-
26
-
-
67349134673
-
A simplified suite of methods to evaluate chelator conjugation of antibodies: Effects on hydrodynamic radius and biodistribution
-
Al Ejeh F, Darby JM, Thierry B, Brown MP. A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution. Nucl Med Biol 2009;36:395-402
-
(2009)
Nucl Med Biol
, vol.36
, pp. 395-402
-
-
Al Ejeh, F.1
Darby, J.M.2
Thierry, B.3
Brown, M.P.4
-
27
-
-
82655181976
-
Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody
-
Shin IS, Lee SM, Kim HS, et al. Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody. Nucl Med Biol 2011;38:1119-27
-
(2011)
Nucl Med Biol
, vol.38
, pp. 1119-1127
-
-
Shin, I.S.1
Lee, S.M.2
Kim, H.S.3
-
28
-
-
79955832182
-
Trastuzumab emtansine: A novel antibody-drug conjugate for HER2-positive breast cancer
-
Burris HA. Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer. Expert Opin Biol Ther 2011;11:807-19
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 807-819
-
-
Burris, H.A.1
-
29
-
-
80054092983
-
Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
-
LoRusso PM, Weiss D, Guardino E, et al. Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res 2011;17:6437-47
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6437-6447
-
-
Lorusso, P.M.1
Weiss, D.2
Guardino, E.3
-
30
-
-
24344456964
-
Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
-
DOI 10.1110/ps.051478705
-
Wang L, Amphlett G, Blattler WA, et al. Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry. Protein Sci 2005;14:2436-46 (Pubitemid 41252812)
-
(2005)
Protein Science
, vol.14
, Issue.9
, pp. 2436-2446
-
-
Wang, L.1
Amphlett, G.2
Blattler, W.A.3
Lambert, J.M.4
Zhang, W.5
-
31
-
-
0037124498
-
Mono-N-terminal poly(ethylene glycol)-protein conjugates
-
DOI 10.1016/S0169-409X(02)00023-6, PII S0169409X02000236
-
Kinstler O, Molineux G, Treuheit M, et al. Mono-N-terminal poly(ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 2002;54:477-85 (Pubitemid 34615544)
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.4
, pp. 477-485
-
-
Kinstler, O.1
Molineux, G.2
Treuheit, M.3
Ladd, D.4
Gegg, C.5
-
32
-
-
79951944060
-
Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor
-
Manjappa AS, Chaudhari KR, Venkataraju MP, et al. Antibody derivatization and conjugation strategies: application in preparation of stealth immunoliposome to target chemotherapeutics to tumor. J Control Release 2011;150:2-22
-
(2011)
J Control Release
, vol.150
, pp. 2-22
-
-
Manjappa, A.S.1
Chaudhari, K.R.2
Venkataraju, M.P.3
-
33
-
-
25444507922
-
Reduction-alkylation strategies for the modification of specific monoclonal antibody bisulfides
-
DOI 10.1021/bc050201y
-
Sun MM, Beam KS, Cerveny CG, et al. Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides. Bioconjug Chem 2005;16:1282-90 (Pubitemid 41368132)
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.5
, pp. 1282-1290
-
-
Sun, M.M.C.1
Beam, K.S.2
Cerveny, C.G.3
Hamblett, K.J.4
Blackmore, R.S.5
Torgov, M.Y.6
Handley, F.G.M.7
Ihle, N.C.8
Senter, P.D.9
Alley, S.C.10
-
34
-
-
50449091735
-
An engineered selenocysteine defines a unique class of antibody derivatives
-
Hofer T, Thomas JD, Burke TR Jr, Rader C. An engineered selenocysteine defines a unique class of antibody derivatives. Proc Natl Acad Sci USA 2008;105:12451-6
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12451-12456
-
-
Hofer, T.1
Thomas, J.D.2
Burke Jr., T.R.3
Rader, C.4
-
35
-
-
49449087300
-
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
-
Junutula JR, Raab H, Clark S, et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol 2008;26:925-32
-
(2008)
Nat Biotechnol
, vol.26
, pp. 925-932
-
-
Junutula, J.R.1
Raab, H.2
Clark, S.3
-
36
-
-
0025140678
-
Site-specific attachment to recombinant antibodies via introduced surface cysteine residues
-
Lyons A, King DJ, Owens RJ, et al. Site-specific attachment to recombinant antibodies via introduced surface cysteine residues. Protein Eng 1990;3:703-8 (Pubitemid 20284843)
-
(1990)
Protein Engineering
, vol.3
, Issue.8
, pp. 703-708
-
-
Lyons, A.1
King, D.J.2
Owens, R.J.3
Yarranton, G.T.4
Millican, A.5
Whittle, N.R.6
Adair, J.R.7
-
37
-
-
54049093284
-
Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index
-
McDonagh CF, Kim KM, Turcott E, et al. Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index. Mol Cancer Ther 2008;7:2913-23
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2913-2923
-
-
McDonagh, C.F.1
Kim, K.M.2
Turcott, E.3
-
38
-
-
0034730518
-
Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies
-
Stimmel JB, Merrill BM, Kuyper LF, et al. Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies. J Biol Chem 2000;275:30445-50
-
(2000)
J Biol Chem
, vol.275
, pp. 30445-30450
-
-
Stimmel, J.B.1
Merrill, B.M.2
Kuyper, L.F.3
-
39
-
-
77049123763
-
Design and application of antibody cysteine variants
-
Voynov V, Chennamsetty N, Kayser V, et al. Design and application of antibody cysteine variants. Bioconjug Chem 2010;21:385-92
-
(2010)
Bioconjug Chem
, vol.21
, pp. 385-392
-
-
Voynov, V.1
Chennamsetty, N.2
Kayser, V.3
-
42
-
-
77953603827
-
Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LCMS Analysis
-
Liu H, Chumsae C, Gaza-Bulseco G, et al. Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LCMS Analysis. Anal Chem 2010;82:5219-26
-
(2010)
Anal Chem
, vol.82
, pp. 5219-5226
-
-
Liu, H.1
Chumsae, C.2
Gaza-Bulseco, G.3
-
43
-
-
0024999394
-
Antigen binding and biological activities of engineered mutant chimeric antibodies with human tumor specificities
-
Gillies SD, Wesolowski JS. Antigen binding and biological activities of engineered mutant chimeric antibodies with human tumor specificities. Hum Antibodies Hybridomas 1990;1:47-54 (Pubitemid 20320603)
-
(1990)
Human Antibodies and Hybridomas
, vol.1
, Issue.1
, pp. 47-54
-
-
Gillies, S.D.1
Wesolowski, J.S.2
-
44
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
DOI 10.1158/1078-0432.CCR-04-0789
-
Hamblett KJ, Senter PD, Chace DF, et al. Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin Cancer Res 2004;10:7063-70 (Pubitemid 39383058)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.20
, pp. 7063-7070
-
-
Hamblett, K.J.1
Senter, P.D.2
Chace, D.F.3
Sun, M.M.C.4
Lenox, J.5
Cerveny, C.G.6
Kissler, K.M.7
Bernhardt, S.X.8
Kopcha, A.K.9
Zabinski, R.F.10
Meyer, D.L.11
Francisco, J.A.12
-
45
-
-
33745684533
-
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment
-
DOI 10.1093/protein/gzl013
-
McDonagh CF, Turcott E, Westendorf L, et al. Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment. Protein Eng Des Sel 2006;19:299-307 (Pubitemid 43999640)
-
(2006)
Protein Engineering, Design and Selection
, vol.19
, Issue.7
, pp. 299-307
-
-
McDonagh, C.F.1
Turcott, E.2
Westendorf, L.3
Webster, J.B.4
Alley, S.C.5
Kim, K.6
Andreyka, J.7
Stone, I.8
Hamblett, K.J.9
Francisco, J.A.10
Carter, P.11
-
46
-
-
40649126110
-
Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs
-
Junutula JR, Bhakta S, Raab H, et al. Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs. J Immunol Methods 2008;332:41-52
-
(2008)
J Immunol Methods
, vol.332
, pp. 41-52
-
-
Junutula, J.R.1
Bhakta, S.2
Raab, H.3
-
47
-
-
34548021197
-
Alternative antibody Fab′ fragment PEGylation strategies: Combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering
-
DOI 10.1093/protein/gzm015
-
Humphreys DP, Heywood SP, Henry A, et al. Alternative antibody Fab fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering. Protein Eng Des Sel 2007;20:227-34 (Pubitemid 351321304)
-
(2007)
Protein Engineering, Design and Selection
, vol.20
, Issue.5
, pp. 227-234
-
-
Humphreys, D.P.1
Heywood, S.P.2
Henry, A.3
Ait-Lhadj, L.4
Antoniw, P.5
Palframan, R.6
Greenslade, K.J.7
Carrington, B.8
Reeks, D.G.9
Bowering, L.C.10
West, S.11
Brand, H.A.12
-
48
-
-
0022557571
-
The role of the V(L)- and V(H)-segments in the preferential reassociation of immunoglobulin subunits
-
DOI 10.1016/0161-5890(86)90113-6
-
Hamel PA, Klein MH, Dorrington KJ. The role of the VL-and VH-segments in the preferential reassociation of immunoglobulin subunits. Mol Immunol 1986;23:503-10 (Pubitemid 16113212)
-
(1986)
Molecular Immunology
, vol.23
, Issue.5
, pp. 503-510
-
-
Hamel, P.A.1
Klein, M.H.2
Dorrington, K.J.3
-
49
-
-
47049114087
-
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass
-
Dillon TM, Ricci MS, Vezina C, et al. Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J Biol Chem 2008;283:16206-15
-
(2008)
J Biol Chem
, vol.283
, pp. 16206-16215
-
-
Dillon, T.M.1
Ricci, M.S.2
Vezina, C.3
-
50
-
-
33646836792
-
Suppression of sodium dodecyl sulfate-polyacrylamide gel electrophoresis sample preparation artifacts for analysis of IgG4 half-antibody
-
DOI 10.1016/j.ab.2006.02.022, PII S0003269706001424
-
Taylor FR, Prentice HL, Garber EA, et al. Suppression of sodium dodecyl sulfate-polyacrylamide gel electrophoresis sample preparation artifacts for analysis of IgG4 half-antibody. Anal Biochem 2006;353:204-8 (Pubitemid 43775437)
-
(2006)
Analytical Biochemistry
, vol.353
, Issue.2
, pp. 204-208
-
-
Taylor, F.R.1
Prentice, H.L.2
Garber, E.A.3
Fajardo, H.A.4
Vasilyeva, E.5
Blake Pepinsky, R.6
-
51
-
-
33846406038
-
Site-specific PEGylation of protein bisulfide bonds using a three-carbon bridge
-
DOI 10.1021/bc0601471
-
Balan S, Choi JW, Godwin A, et al. Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge. Bioconjug Chem 2007;18:61-76 (Pubitemid 46145995)
-
(2007)
Bioconjugate Chemistry
, vol.18
, Issue.1
, pp. 61-76
-
-
Balan, S.1
Choi, J.-W.2
Godwin, A.3
Teo, I.4
Laborde, C.M.5
Heidelberger, S.6
Zloh, M.7
Shaunak, S.8
Brocchini, S.9
-
52
-
-
84865322651
-
-
Last accessed 3 March 2012
-
Mylotarg package insert: W10477C009 ET01. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2006/021174s020lbl.pdf [Last accessed 3 March 2012]
-
Mylotarg Package Insert: W10477C009 ET01
-
-
-
53
-
-
4544320025
-
Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma
-
DOI 10.1158/1078-0432.CCR-04-1134
-
DiJoseph JF, Goad ME, Dougher MM, et al. Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma. Clin Cancer Res 2004;10:8620-9 (Pubitemid 40053430)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.24
, pp. 8620-8629
-
-
DiJoseph, J.F.1
Goad, M.E.2
Dougher, M.M.3
Boghaert, E.R.4
Kunz, A.5
Hamann, P.R.6
Damle, N.K.7
-
54
-
-
84865326513
-
-
Seattle Genetics Inc Last accessed 3 March 2012
-
Full Prescribing Information for Adcetris. Seattle Genetics, Inc. Available from: http://www.adcetris.com/-pdf/Final-Adcetris-USPI-Jan12-2012.pdf [Last accessed 3 March 2012]
-
Full Prescribing Information for Adcetris
-
-
-
55
-
-
84865322652
-
-
CDER Application No 125388Orig1s000 Chemistry Review(s). Center For Drug Evaluation And Research Last accessed 3 March 2012
-
CDER Application No 125388Orig1s000 Chemistry Review(s). Center for Drug Evaluation and Research. Available from: http://www.accessdata.fda.gov/ drugsatfda-docs/nda/2011/125388Orig1s000ChemR.pdf [Last accessed 3 March 2012]
-
-
-
-
56
-
-
84863012529
-
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
-
Shen BQ, Xu K, Liu L, et al. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol 2012;30:184-9
-
(2012)
Nat Biotechnol
, vol.30
, pp. 184-189
-
-
Shen, B.Q.1
Xu, K.2
Liu, L.3
-
57
-
-
79953052077
-
Selective formation of covalent protein heterodimers with an unnatural amino acid
-
Hutchins BM, Kazane SA, Staflin K, et al. Selective formation of covalent protein heterodimers with an unnatural amino acid. Chem Biol 2011;18:299-303
-
(2011)
Chem Biol
, vol.18
, pp. 299-303
-
-
Hutchins, B.M.1
Kazane, S.A.2
Staflin, K.3
-
58
-
-
79955022475
-
Disulfide-linked antibody-maytansinoid conjugates: Optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage
-
Kellogg BA, Garrett L, Kovtun Y, et al. Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage. Bioconjug Chem 2011;22:717-27
-
(2011)
Bioconjug Chem
, vol.22
, pp. 717-727
-
-
Kellogg, B.A.1
Garrett, L.2
Kovtun, Y.3
-
59
-
-
74949107560
-
Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
-
Ducry L, Stump B. Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem 2010;21:5-13
-
(2010)
Bioconjug Chem
, vol.21
, pp. 5-13
-
-
Ducry, L.1
Stump, B.2
-
62
-
-
77950224905
-
Antibody-maytansinoid conjugates designed to bypass multidrug resistance
-
Kovtun YV, Audette CA, Mayo MF, et al. Antibody-maytansinoid conjugates designed to bypass multidrug resistance. Cancer Res 2010;70:2528-37
-
(2010)
Cancer Res
, vol.70
, pp. 2528-2537
-
-
Kovtun, Y.V.1
Audette, C.A.2
Mayo, M.F.3
-
63
-
-
33645500289
-
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
-
Erickson HK, Park PU, Widdison WC, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res 2006;66:4426-33
-
(2006)
Cancer Res
, vol.66
, pp. 4426-4433
-
-
Erickson, H.K.1
Park, P.U.2
Widdison, W.C.3
-
64
-
-
78650286160
-
Investigational antibody-drug conjugates for hematological malignancies
-
Polson AG, Ho WY, Ramakrishnan V. Investigational antibody-drug conjugates for hematological malignancies. Expert Opin Investig Drugs 2011;20:75-85
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 75-85
-
-
Polson, A.G.1
Ho, W.Y.2
Ramakrishnan, V.3
-
65
-
-
80054098573
-
Antibody conjugate therapeutics: Challenges and potential
-
Teicher BA, Chari RV. Antibody conjugate therapeutics: challenges and potential. Clin Cancer Res 2011;17:6389-97
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6389-6397
-
-
Teicher, B.A.1
Chari, R.V.2
-
66
-
-
74849092615
-
Antibody-drug conjugate targets
-
Teicher BA. Antibody-drug conjugate targets. Curr Cancer Drug Targets 2009;9:982-1004
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 982-1004
-
-
Teicher, B.A.1
-
67
-
-
77953655955
-
Industrialization of mAb production technology: The bioprocessing industry at a crossroads
-
Kelley B. Industrialization of mAb production technology: the bioprocessing industry at a crossroads. MAbs 2009;1:443-52
-
(2009)
MAbs
, vol.1
, pp. 443-452
-
-
Kelley, B.1
-
68
-
-
78651378808
-
Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: Mechanisms of action and resistance, safety and efficacy
-
Breccia M, Lo-Coco F. Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: mechanisms of action and resistance, safety and efficacy. Expert Opin Biol Ther 2011;11:225-34
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 225-234
-
-
Breccia, M.1
Lo-Coco, F.2
-
69
-
-
80052509765
-
Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia
-
Hutter ML, Schlenk RF. Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia. Expert Opin Biol Ther 2011;11:1369-80
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 1369-1380
-
-
Hutter, M.L.1
Schlenk, R.F.2
-
70
-
-
80054113954
-
Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
-
Ricart AD. Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res 2011;17:6417-27
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6417-6427
-
-
Ricart, A.D.1
-
71
-
-
0034900174
-
Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
-
Bross PF, Beitz J, Chen G, et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 2001;7:1490-6 (Pubitemid 32708610)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.6
, pp. 1490-1496
-
-
Bross, P.F.1
Beitz, J.2
Chen, G.3
Xiao Hong Chen4
Duffy, E.5
Kieffer, L.6
Roy, S.7
Sridhara, R.8
Rahman, A.9
Williams, G.10
Pazdur, R.11
-
72
-
-
84865316942
-
-
Pfizer Prepares For Voluntary Withdrawal Of U.S Pfizer Inc Last accessed 3 March 2012
-
Pfizer prepares for voluntary withdrawal of U.S. New drug application and for discontinuation of commercial availability Of Mylotarg® . Pfizer, Inc. Available from: http://www.pfizer.com/files/news/press-releases/2010/mylotarg- discontinuation-062110.pdf [Last accessed 3 March 2012]
-
New Drug Application and for Discontinuation of Commercial Availability of Mylotarg®
-
-
-
74
-
-
84865331380
-
-
S0106 Cytarabine And Daunorubicin With Or Without Gemtuzumab Ozogamicin Followed By High-dose Cytarabine Followed By Either Gemtuzumab Ozogamicin Or No Additional Therapy In Treating Patients With Previously Untreated De Novo Acute Myeloid Leukemia. ClinicalTrials.gov Last accessed 3 March 2012
-
S0106 Cytarabine and Daunorubicin with or without Gemtuzumab Ozogamicin Followed by high-dose cytarabine followed by either Gemtuzumab Ozogamicin or No additional therapy in treating patients with previously untreated De Novo acute myeloid leukemia. ClinicalTrials.gov Available from: http://www.clinicaltrials. gov/ct2/show/NCT00085709?term=S0106&rank=1 [Last accessed 3 March 2012]
-
-
-
-
76
-
-
84865331417
-
-
Cancernetwork.com Last accessed 3 March 2012
-
ASH: Gemtuzumab\-A Potential New Use for an Old Drug in AML. cancernetwork.com. Available from: http://www.cancernetwork. com/conference-reports/ash2011/content/article/10165/2005126 [Last accessed 3 March 2012]
-
ASH: Gemtuzumab-A Potential New Use for An Old Drug in AML
-
-
-
77
-
-
84865312848
-
-
BLOOMBERG L.P Last accessed 3 March 2012
-
Pfizer's failed blood cancer drug shows benefits in study of new patients. BLOOMBERG L.P. Available from: http://www.bloomberg.com/news/2011-12- 10/pfizer-s-failed-blood-cancer-drug-shows-benefits-in-study-of-new-patients. html [Last accessed 3 March 2012]
-
Pfizer's Failed Blood Cancer Drug Shows Benefits in Study of New Patients
-
-
-
78
-
-
84865326558
-
-
Genentech Inc Last accessed 3 March 2012
-
Genentech Provides Update on FDA Application for T-DM1. Genentech, Inc. Available from: http://www.gene.com/gene/news/press-releases/display.do?method= detail&id=12947 [Last accessed 3 March 2012]
-
Genentech Provides Update on FDA Application for T-DM1
-
-
-
82
-
-
78650301478
-
Brentuximab vedotin: Delivering an antimitotic drug to activated lymphoma cells
-
Ansell SM. Brentuximab vedotin: delivering an antimitotic drug to activated lymphoma cells. Expert Opin Investig Drugs 2011;20:99-105
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 99-105
-
-
Ansell, S.M.1
-
84
-
-
84865326546
-
-
Drug Approval Package: ADCETRIS (brentuximab Vedotin). U.S. Food And Drug Administration Last accessed 3 March 2012
-
Drug Approval Package: ADCETRIS (brentuximab vedotin). U.S. Food and Drug Administration. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/ nda/2011/125399-adcetris-toc.cfm [Last accessed 3 March 2012]
-
-
-
-
85
-
-
84865347192
-
-
Briefing Information For The July 14 2011 Meeting Of The Oncologic Drugs Advisory Committee. U.S. Food And Drug Administration Last accessed 3 March 2012
-
Briefing Information for the July 14, 2011 Meeting of the Oncologic Drugs Advisory Committee. U.S. Food and Drug Administration. Available from: http://www.fda.gov/advisorycommittees/committeesmeetingmaterials/drugs/ oncologicdrugsadvisorycommittee/ucm262590.htm [Last accessed 3 March 2012]
-
-
-
-
86
-
-
79851475357
-
Immunogenicity of protein therapeutics: The key causes, consequences and challenges
-
Baker MP, Reynolds HM, Lumicisi B, Bryson CJ. Immunogenicity of protein therapeutics: the key causes, consequences and challenges. Self Nonself 2010;1:314-22
-
(2010)
Self Nonself
, vol.1
, pp. 314-322
-
-
Baker, M.P.1
Reynolds, H.M.2
Lumicisi, B.3
Bryson, C.J.4
-
87
-
-
77953658260
-
The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions
-
Harding FA, Stickler MM, Razo J, DuBridge RB. The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions. MAbs 2010;2:256-65
-
(2010)
MAbs
, vol.2
, pp. 256-265
-
-
Harding, F.A.1
Stickler, M.M.2
Razo, J.3
Dubridge, R.B.4
-
88
-
-
77954681710
-
Inotuzumab ozogamicin as novel therapy in lymphomas
-
Wong BY, Dang NH. Inotuzumab ozogamicin as novel therapy in lymphomas. Expert Opin Biol Ther 2010;10:1251-8
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 1251-1258
-
-
Wong, B.Y.1
Dang, N.H.2
-
91
-
-
84865347197
-
-
Seattle Genetics Inc Last accessed 3 March 2012
-
Antibody-drug Conjugate Technology Collaborations. Seattle Genetics, Inc. Available from: http://www.seagen.com/collaborations-ADC.shtml [Last accessed 3 March 2012]
-
Antibody-drug Conjugate Technology Collaborations
-
-
-
92
-
-
84865311658
-
-
Immunogen Inc.: Securities and Exchange Commission form 8-K: Nov 29, 2011 Last accessed 3 March 2012
-
Immunogen, Inc.: Securities and Exchange Commission form 8-K: Nov 29, 2011. Available from: http://www.faqs.org/sec-filings/111129/IMMUNOGEN-INC-8-K/ [Last accessed 3 March 2012]
-
-
-
-
93
-
-
84865311664
-
-
Last accessed 3 March 2012
-
Morphosys 3rd Interim Report Oct 2011. Available from: http://www.morphosys.com/sites/default/files/111028-MOR-Q3-2011-e.pdf [Last accessed 3 March 2012]
-
Morphosys 3rd Interim Report Oct 2011
-
-
-
94
-
-
84865347195
-
-
Wilex AG Announces Acquisition Of Heidelberg Pharma AG. WILEX AG Last accessed 3 March 2012
-
Wilex AG announces acquisition of Heidelberg Pharma AG. WILEX AG. Available from: http://www.wilex.de/pdf/Adhoc/2010/20101103-AH-WILEX- HDPAcquisition-eng.pdf [Last accessed 3 March 2012]
-
-
-
-
95
-
-
84865326555
-
-
Synthon BV Last accessed 3 March 2012
-
Synthon acquires Syntarga and its Antibody-Drug Conjugate Technology. Synthon BV. Available from: http://www.synthon.com/en/nieuwsarchief/synthon- acquires-syntarga-and-its-antibody-drug-conjugate-technology.aspx [Last accessed 3 March 2012]
-
Synthon Acquires Syntarga and Its Antibody-Drug Conjugate Technology
-
-
-
97
-
-
84865326556
-
-
Seattle Genetics Inc Last accessed 23 April 2012
-
Seattle Genetics Demonstrates Continued Leadership in Antibody-Drug Conjugates at AACR. Seattle Genetics, Inc. Available from: http://www. businesswire.com/news/home/20120403006655/en/Seattle-Genetics-Demonstrates- Continued-Leadership-Antibody-Drug-Conjugates [Last accessed 23 April 2012]
-
Seattle Genetics Demonstrates Continued Leadership in Antibody-Drug Conjugates at AACR
-
-
|