A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

Nuclear Medicine and Biology

Volumn 36, Issue 4, 2009, Pages 395-402

  Al Ejeh, Fares ^a   Darby, Jocelyn M ^a   Thierry, Benjamin ^b   Brown, Michael P ^a,c  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

DOTA antibody ratio; Hydrodynamic radius; Radioimmunoconjugates; Radioimmunoscintigraphy; Radioimmunotherapy

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ANTIBODY CONJUGATE; APOMAB; AUTOANTIBODY; LA ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DAB4; UNCLASSIFIED DRUG;

ARTICLE; CHELATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDRODYNAMICS; IMMUNOSCINTIGRAPHY; ISOTOPE LABELING; MICROTITER PLATE ASSAY; RADIOACTIVITY; RADIOIMMUNOTHERAPY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ARSENAZO III; AUTOANTIGENS; CELL LINE, TUMOR; CHELATING AGENTS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; IMMUNOCONJUGATES; METALS; MICE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 67349134673     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.01.001     Document Type: Article

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