Dual effects of β3 integrin subunit expression on human pancreatic cancer models

Cellular Oncology

Volumn 34, Issue 4, 2011, Pages 393-405

  Marchan S ^a   Perez Torras S ^a   Vidal, A ^a   Adan, J ^b,c   Mitjans, F ^b,c   Carbo N ^a   Mazo, A ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Laboratori de Bioinvestigació LBI   (Spain)

^c LEITAT TECHNOLOGICAL CENTER   (Spain)

Author keywords

v 3; Cell migration; Integrins; Pancreatic cancer; Tumor growth

Indexed keywords

BLOCKING ANTIBODY; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; VITRONECTIN RECEPTOR; ANTIBODY; BETA3 INTEGRIN; ITGB3 PROTEIN, HUMAN;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOIKIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; FOCAL ADHESION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TUMOR GROWTH; ANIMAL; APOPTOSIS; CELL CYCLE; CELL MOTION; CELL SHAPE; CELL SIZE; DRUG EFFECT; DRUG SCREENING; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PROTEIN SUBUNIT; TUMOR CELL LINE;

ANIMALS; ANTIBODIES; APOPTOSIS; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; CELL SIZE; HUMANS; INTEGRIN BETA3; MICE; PANCREATIC NEOPLASMS; PROTEIN SUBUNITS; RHO GTP-BINDING PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865340591     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-011-0039-3     Document Type: Article

References (42)

1. A. Abdollahi, D.W. Griggs, H. Zieher, A. Roth, K.E. Lipson, R. Saffrich, H.J. Grone, D.E. Hallahan, R.A. Reisfeld, J. Debus, A.G. Niethammer, P.E. Huber, Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res 11, 6270-6279 (2005) (Pubitemid 41262958)
2. Y. Adachi, S.S. Lakka, N. Chandrasekar, N. Yanamandra, C.S. Gondi, S. Mohanam, D.H. Dinh, W.C. Olivero, M. Gujrati, T. Tamiya, T. Ohmoto, G. Kouraklis, B. Aggarwal, J.S. Rao, Downregulation of integrin alpha(v)beta(3) expression and integrinmediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes. J Biol Chem 276, 47171-47177 (2001)
3. S.M. Albelda, S.A. Mette, D.E. Elder, R. Stewart, L. Damjanovich, M. Herlyn, C.A. Buck, Integrin distribution in malignant melanoma: Association of the beta 3 subunit with tumor progression. Cancer Res 50, 6757-6764 (1990) (Pubitemid 20348810)
4. E. Alhaja, J. Adan, R. Pagan, F. Mitjans, M. Cascallo, M. Rodriguez, V. Noe, C.J. Ciudad, A. Mazo, S. Vilaro, J. Piulats, Anti-migratory and anti-angiogenic effect of p16: A novel localization at membrane ruffles and lamellipodia in endothelial cells. Angiogenesis 7, 323-333 (2004) (Pubitemid 40767934)
5. A. Besson, M. Gurian-West, A. Schmidt, A. Hall, J.M. Roberts, p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18, 862-876 (2004) (Pubitemid 38529656)
6. M.F. Burbridge, V. Venot, P.J. Casara, F. Perron-Sierra, J.A. Hickman, G.C. Tucker, Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist. Mol Pharmacol 63, 1281-1288 (2003) (Pubitemid 36627222)
7. G. Capella, L. Farre, A. Villanueva, G. Reyes, C. Garcia, G. Tarafa, F. Lluis, Orthotopic models of human pancreatic cancer. Ann N Y Acad Sci 880, 103-109 (1999) (Pubitemid 29349118)
8. N. Cordes, Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury. Cancer Lett 242, 11-19 (2006) (Pubitemid 44485301)
9. E.H. Danen, A. Sonnenberg, Integrins in regulation of tissue development and function. J Pathol 201, 632-641 (2003)
10. E.H. Danen, P. Sonneveld, C. Brakebusch, R. Fassler, A. Sonnenberg, The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol 159, 1071-1086 (2002) (Pubitemid 36055761)
11. E.H. Danen, J. van Rheenen, W. Franken, S. Huveneers, P. Sonneveld, K. Jalink, A. Sonnenberg, Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol 169, 515-526 (2005) (Pubitemid 40686701)
12. J.S. Desgrosellier, L.A. Barnes, D.J. Shields, M. Huang, S.K. Lau, N. Prevost, D. Tarin, S.J. Shattil, D.A. Cheresh, An integrin alpha (v)beta(3)-c-Src oncogenic unit promotes anchorageindependence and tumor progression. Nat Med 15, 1163-1169 (2009)
13. M.S. Duxbury, H. Ito, S.W. Ashley, E.E. Whang, c-Src-dependent cross-talk between CEACAM6 and alphavbeta3 integrin enhances pancreatic adenocarcinoma cell adhesion to extracellular matrix components. Biochem Biophys Res Commun 317, 133-141 (2004) (Pubitemid 38401974)
14. R. Fahraeus, D.P. Lane, The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J 18, 2106-2118 (1999) (Pubitemid 29179168)
15. S.M. Frisch, E. Ruoslahti, Integrins and anoikis. Curr Opin Cell Biol 9, 701-706 (1997) (Pubitemid 27424927)
16. M.Z. Gilcrease, Integrin signaling in epithelial cells. Cancer Lett 247, 1-25 (2007) (Pubitemid 44959416)
17. J.J. Grzesiak, J.C. Ho, A.R. Moossa, M. Bouvet, The integrinextracellular matrix axis in pancreatic cancer. Pancreas 35, 293-301 (2007) (Pubitemid 350307370)
18. D.S. Harburger, D.A. Calderwood, Integrin signalling at a glance. J Cell Sci 122, 159-163 (2009)
19. R. Hosotani, M. Kawaguchi, T. Masui, T. Koshiba, J. Ida, K. Fujimoto, M. Wada, R. Doi, M. Imamura, Expression of integrin alphaVbeta3 in pancreatic carcinoma: Relation to MMP-2 activation and lymph node metastasis. Pancreas 25, e30-e35 (2002)
20. S. Huveneers, H. Truong, H.J. Danen, Integrins: Signaling, disease, and therapy. Int J Radiat Biol 83, 743-751 (2007) (Pubitemid 350219110)
21. R.O. Hynes, A reevaluation of integrins as regulators of angiogenesis. Nat Med 8, 918-921 (2002) (Pubitemid 35033683)
22. M. Kanamori, S.R. Vanden Berg, G. Bergers, M.S. Berger, R.O. Pieper, Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: Implications for the role of beta3 overexpression in glioblastoma multiforme. Cancer Res 64, 2751-2758 (2004) (Pubitemid 38500612)
23. T. Kawaguchi, Y. Yamashita, M. Kanamori, R. Endersby, K.S. Bankiewicz, S.J. Baker, G. Bergers, R.O. Pieper, The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growthinhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res 66, 11331-11340 (2006) (Pubitemid 46009964)
24. N.I. Kozlova, G.E. Morozevich, A.N. Chubukina, A.E. Berman, Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells. Oncogene 20, 4710-4717 (2001) (Pubitemid 32762442)
25. K.R. Legate, S.A. Wickstrom, R. Fassler, Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23, 397-418 (2009)
26. T. Manes, D.Q. Zheng, S. Tognin, A.S. Woodard, P.C. Marchisio, L.R. Languino, Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol 161, 817-826 (2003) (Pubitemid 36648764)
27. A. Noguchi, N. Ito, H. Sawa, M. Nagane, M. Hara, I. Saito, Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells. Brain Tumor Pathol 18, 73-81 (2001)
28. T. Plath, K. Detjen, M. Welzel, Z. von Marschall, D. Murphy, M. Schirner, B. Wiedenmann, S. Rosewicz, A novel function for the tumor suppressor p16(INK4a): Induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J Cell Biol 150, 1467-1478 (2000)
29. X.D. Ren, W.B. Kiosses, M.A. Schwartz, Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18, 578-585 (1999) (Pubitemid 29057242)
30. S.F. Retta, G. Cassara, M. D'Amato, R. Alessandro, M. Pellegrino, S. Degani, G. De Leo, L. Silengo, G. Tarone, Cross talk between beta(1) and alpha(V) integrins: Beta(1) affects beta (3) mRNA stability. Mol Biol Cell 12, 3126-3138 (2001)
31. A.R. Reynolds, L.E. Reynolds, T.E. Nagel, J.C. Lively, S.D. Robinson, D.J. Hicklin, S.C. Bodary, K.M. Hodivala-Dilke, Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrindeficient mice. Cancer Res 64, 8643-8650 (2004) (Pubitemid 39552078)
32. L.E. Reynolds, L. Wyder, J.C. Lively, D. Taverna, S.D. Robinson, X. Huang, D. Sheppard, R.O. Hynes, K.M. Hodivala-Dilke, Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 8, 27-34 (2002) (Pubitemid 34101725)
33. A.J. Ridley, Rho GTPases and cell migration. J Cell Sci 114, 2713-2722 (2001) (Pubitemid 32785451)
34. E. Sahai, Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15, 87-96 (2005) (Pubitemid 40127636)
35. R. Soldi, S. Mitola, M. Strasly, P. Defilippi, G. Tarone, F. Bussolino, Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18, 882-892 (1999) (Pubitemid 29082268)
36. C.H. Streuli, Integrins and cell-fate determination. J Cell Sci 122, 171-177 (2009)
37. D. Taverna, D. Crowley, M. Connolly, R.T. Bronson, R.O. Hynes, A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res 65, 10324-10329 (2005) (Pubitemid 41743725)
38. K. Tzukert, N. Shimony, L. Krasny, S. Urieli-Shoval, R. Gorodetsky, I. Avrahami, D.M. Nettelbeck, and Y.S. Haviv, Human melanoma cells expressing the alphavbeta3 integrin are partially protected from necrotic cell death induced by dynamic matrix detachment. Cancer Lett. (2009).
39. P. Villalonga, A.J. Ridley, Rho GTPases and cell cycle control. Growth Factors 24, 159-164 (2006) (Pubitemid 44669346)
40. G.K. Wang, W. Zhang, The signaling network of tumor invasion. Histol Histopathol 20, 593-602 (2005) (Pubitemid 40468278)
41. Y. Wu, J. Zuo, G. Ji, H. Saiyin, X. Liu, F. Yin, N. Cao, Y. Wen, J. J. Li, L. Yu, Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells. Clin Cancer Res 15, 60-69 (2009)
42. D.Q. Zheng, A.S. Woodard, M. Fornaro, G. Tallini, L.R. Languino, Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res 59, 1655-1664 (1999) (Pubitemid 29160140)