Klotho inhibits the capacity of cell migration and invasion in cervical cancer

Oncology Reports

Volumn 28, Issue 3, 2012, Pages 1022-1028

  Chang, Boogi ^a   Kim, Jinsun ^a   Jeong, Dongjun ^b   Jeong, Yujun ^b   Jeon, Seob ^b   Jung, Sam Il ^a   Yang, Young ^a   Kim, Keun Il ^a   Lim, Jong Seok ^a   Kim, Changjin ^b   Lee, Myeong Sok ^a  

^a Sookmyung Women's University   (South Korea)

^b Soonchunhyang University   (South Korea)

Author keywords

Cervical cancer; Epithelial to mesenchymal transition; Klotho; Metastasis; Wnt catenin pathway

Indexed keywords

BETA CATENIN; CYCLIN D1; GELATINASE B; KLOTHO PROTEIN; MATRILYSIN; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; PROTEIN ANTIBODY; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; WNT PROTEIN;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT RESPONSE; UTERINE CERVIX CANCER;

CADHERINS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONIDASE; HUMAN PAPILLOMAVIRUS 16; HUMANS; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PAPILLOMAVIRUS INFECTIONS; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR; UTERINE CERVICAL NEOPLASMS; WNT SIGNALING PATHWAY;

EID: 84865340299     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1865     Document Type: Article

References (40)

1. Parkin DM and Bray F: The burden of HPV-related cancers. Vaccine 24 (Suppl 3): Chapter 2: S3/11-25, 2006.
2. Woodman CB, Collins SI and Young LS: The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 7: 11-22, 2007.
3. Parkin DM, Bray F, Ferlay J and Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153-156, 2001.
4. Uren A, Fallen S, Yuan H, Usubutun A, Kucukali T, Schlegel R, et al: Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 65: 6199-6206, 2005.
5. Perez-Plasencia C, Duenas-Gonzalez A and Alatorre-Tavera B: Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. Int Arch Med 1: 10, 2008.
6. MacDonald BT, Tamai K and He X: Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26, 2009.
7. Paul S and Dey A: Wnt signaling and cancer development: therapeutic implication. Neoplasma 55: 165-176, 2008.
8. Shinohara A, Yokoyama Y, Wan X, Takahashi Y, Mori Y, Takami T, et al: Cytoplasmic/nuclear expression without mutation of exon 3 of the β-catenin gene is frequent in the development of the neoplasm of the uterine cervix. Gynecol Oncol 82: 450-455, 2001.
9. Ueda M, Gemmill RM, West J, Winn R, Sugita M, Tanaka N, et al: Mutations of the β- and γ-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas. Br J Cancer 85: 64-68, 2001.
10. Chung MT, Sytwu HK, Yan MD, Shih YL, Chang CC, Yu MH, et al: Promoter methylation of SFRPs gene family in cervical cancer. Gynecol Oncol 112: 301-306, 2009.
11. Lee EJ, Jo M, Rho SB, Park K, Yoo YN, Park J, et al: Dkk3, downregulated in cervical cancer, functions as a negative regulator of β-catenin. Int J Cancer 124: 287-297, 2009.
12. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51, 1997.
13. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, et al: Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 565: 143-147, 2004.
14. Chen CD, Podvin S, Gillespie E, Leeman SE and Abraham CR: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA 104: 19796-19801, 2007.
15. Mian IS: Sequence, structural, functional, and phylogenetic analyses of three glycosidase families. Blood Cells Mol Dis 24: 83-100, 1998.
16. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, et al: Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281: 6120-6123, 2006.
17. Tao Y, Pinzi V, Bourhis J and Deutsch E: Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat Clin Pract Oncol 4: 591-602, 2007.
18. Mattarocci S, Abbruzzese C, Mileo AM, Visca P, Antoniani B, Alessandrini G, et al: Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer. J Cell Physiol 221: 766-770, 2009.
19. Lee J, Jeong DJ, Kim J, Lee S, Park JH, Chang B, et al: The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer 9: 109, 2010.
20. Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, et al: Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27: 7094-7105, 2008.
21. Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273, 2009.
22. Huber AH and Weis WI: The structure of the β-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by β-catenin. Cell 105: 391-402, 2001.
23. Laux H, Tomer R, Mader MT, Smida J, Budczies J, Kappler R, et al: Tumor-associated E-cadherin mutations do not induce Wnt target gene expression, but affect E-cadherin repressors. Lab Invest 84: 1372-1386, 2004.
24. Yang J and Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008.
25. Vallin J, Thuret R, Giacomello E, Faraldo MM, Thiery JP and Broders F: Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/β-catenin signaling. J Biol Chem 276: 30350-30358, 2001.
26. Howe LR, Watanabe O, Leonard J and Brown AM: Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res 63: 1906-1913, 2003.
27. Marchenko GN, Marchenko ND, Leng J and Strongin AY: Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. Biochem J 363: 253-262, 2002.
28. Wu B, Crampton SP and Hughes CC: Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 26: 227-239, 2007.
29. Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, et al: The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer 9: 162, 2010.
30. Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas MS, Gudkov AV, et al: c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle. Oncogene 27: 1905-1915, 2008.
31. Fu M, Wang C, Li Z, Sakamaki T and Pestell RG: Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145: 5439-5447, 2004.
32. Kainz C, Kohlberger P, Tempfer C, Sliutz G, Gitsch G, Reinthaller A, et al: Prognostic value of CD44 splice variants in human stage III cervical cancer. Eur J Cancer 31A: 1706-1709, 1995.
33. Wang L, Wang X, Jie P, Lu H, Zhang S, Lin X, et al: Klotho is silenced through promoter hypermethylation in gastric cancer. Am J Cancer Res 1: 111-119, 2011.
34. King GD, Rosene DL and Abraham CR: Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr): Sep 16, 2011 (Epub ahead of print).
35. Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, et al: Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol 32: 729-735, 2011.
36. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, et al: Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806, 2007.
37. Kang Y and Massague J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279, 2004.
38. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, et al: Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665, 2011.
39. Branca M, Giorgi C, Ciotti M, Santini D, Di Bonito L, Costa S, et al: Down-regulation of E-cadherin is closely associated with progression of cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus (HPV) or disease outcome in cervical cancer. Eur J Gynaecol Oncol 27: 215-223, 2006.
40. Camilli TC, Xu M, O'Connell MP, Chien B, Frank BP, Subaran S, et al: Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res 24: 175-186, 2011.