Cytoplasmic/nuclear expression without mutation of exon 3 of the β-catenin gene is frequent in the development of the neoplasm of the uterine cervix

Gynecologic Oncology

Volumn 82, Issue 3, 2001, Pages 450-455

  Shinohara, Ariyoshi ^a   Yokoyama, Yasuhiro ^a   Wan, Xiaoyun ^a   Takahashi, Yuichiro ^a   Mori, Yoshio ^b   Takami, Tsuyoshi ^a   Shimokawa, Kuniyasu ^a   Tamaya, Teruhiko ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Tokai Central Hospital of Japan Mutual Aid Association of Public School Teachers   (Japan)

Author keywords

Carcinoma; Dysplasia; Immunocytochemistry; Mutation; Uterine cervix; Wnt signaling pathway cell cell adhesion; catenin

Indexed keywords

BETA CATENIN;

ARTICLE; CANCER GRADING; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; EXON; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; PRECANCER; PRIORITY JOURNAL; SOMATIC MUTATION; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX DYSPLASIA;

EID: 0034830582     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.2001.6298     Document Type: Article

References (27)

1. Beta-catenin as oncogene: The smoking gun
2. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
3. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
4. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
5. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
6. Stabilization of beta-catenin by genetic defects in melanoma cell lines
7. Beta-catenin mutation in carcinoma of the uterine endometrium
8. Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: Frequent mutations at codon 34 that cause nuclear accumulation
9. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
10. Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors
11. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma
12. Cellular mechanisms of wingless/Wnt signal transduction
13. Interaction between Wnt and TGF-beta signaling pathways during formation of Spemann's organizer
14. The adenomatous polyposis coli (APC) tumor suppressor
15. Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma
16. Well-differentiated villoglandular adenocarcinoma of the uterine cervix: Oncogene/tumor suppressor gene alterations and human papillomavirus genotyping
17. Wnt signaling and cancer
18. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family
19. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family
20. Beta-catenin expression pattern in stage I and II ovarian carcinomas relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
21. Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer
22. Beta-catenin expression in primary and metastatic colorectal carcinoma
23. Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
24. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
25. Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression array
26. Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix
27. Expression of E-cadherin and alpha- and beta-catenin mRNAs in uterine cervical cancers