Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine

Aquatic Toxicology

Volumn 124-125, Issue , 2012, Pages 72-82

  James, Margaret O ^a   Marth, Christopher J ^a,b   Rowland Faux, Laura ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biotransformation; Channel catfish; Glucuronidation; Methyl triclosan; O Demethylation; Sulfonation

Indexed keywords

3 METHYLCHOLANTHRENE; 3,3',4',4,5 PENTACHLOROBIPHENYL; CLOTRIMAZOLE; CYTOCHROME P450; DIMETHYL SULFOXIDE; KETOCONAZOLE; METHYLTRICLOSAN; PHENOL; POLYCHLORINATED BIPHENYL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRICLOSAN; UNCLASSIFIED DRUG;

ANATOMY; BIOACCUMULATION; BIOTRANSFORMATION; CYTOCHROME; ENZYME ACTIVITY; FISH; FOOD CHAIN; INHIBITION; PHENOLIC COMPOUND; POLLUTION EFFECT; POLLUTION EXPOSURE; SULFONATE;

ACCURACY; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CELL FRACTIONATION; CHANNEL CATFISH; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TEMPERATURE; INTESTINE; LIMIT OF QUANTITATION; LIVER; MASS SPECTROMETRY; METABOLISM; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; SULFONATION; SUMMER; WATER TEMPERATURE;

ANIMALS; BIOTRANSFORMATION; CYTOSOL; DIET; DIMETHYL SULFOXIDE; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLUCURONIDES; ICTALURIDAE; INTESTINES; LIVER; METHYLATION; MICROSOMES; TEMPERATURE; TRICLOSAN; WATER POLLUTANTS, CHEMICAL;

ICTALURUS PUNCTATUS; INVERTEBRATA;

EID: 84865334806     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2012.07.009     Document Type: Article

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