Expression of antimicrobial peptides in cutaneous infections after skin surgery

British Journal of Dermatology

Volumn 163, Issue 1, 2010, Pages 121-127

  Kesting, M R ^a   Stoeckelhuber, M ^a   Holzle F ^a   Mucke T ^a   Neumann, K ^a   Woermann, K ^a   Jacobsen, F ^b   Steinstraesser, L ^b   Wolff, K D ^a   Loeffelbein, D J ^a   Rohleder, N H ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

human defensin; innate immunity; psoriasin; S100A7; surgical site infection

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; PSORIASIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EPITHELIUM; FEMALE; GENETIC CODE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFECTION; SKIN SURGERY; TISSUE DISTRIBUTION;

EID: 77953977632     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.09781.x     Document Type: Article

References (33)

1. Gould IM. The epidemiology of antibiotic resistance. Int J Antimicrob Agents 2008 32 (Suppl. 1 S2 9.
2. Wilson MA. Skin and soft-tissue infections: impact of resistant Gram-positive bacteria. Am J Surg 2003 186 : 35S 43S, 61S-64S.
3. Livermore DM. The need for new antibiotics. Clin Microbiol Infect 2004 10 (Suppl. 4 1 9.
4. Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol 2005 125 : 9 13.
5. Schittek B, Paulmann M, Senyürek I, Steffen H. The role of antimicrobial peptides in human skin and in skin infectious diseases. Infect Disord Drug Targets 2008 8 : 135 143.
6. Kaus A, Jacobsen F, Sorkin M et al. Host defence peptides in human burns. Burns 2008 34 : 32 40.
7. Steinstraesser L, Koehler T, Jacobsen F et al. Host defense peptides in wound healing. Mol Med 2008 14 : 528 537.
8. Gallo RL, Huttner KM. Antimicrobial peptides: an emerging concept in cutaneous biology. J Invest Dermatol 1998 111 : 739 743.
9. Lehrer RI, Barton A, Daher KA et al. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 1989 84 : 553 561.
10. Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 1990 87 : 210 214.
11. Harder J, Bartels J, Christophers E, Schroder JM. A peptide antibiotic from human skin. Nature 1997 387 : 861.
12. Stoeckelhuber M, Matthias C, Andratschke M et al. Human ceruminous gland: ultrastructure and histochemical analysis of antimicrobial and cytoskeletal components. Anat Rec A Discov Mol Cell Evol Biol 2006 288 : 877 884.
13. Stoeckelhuber M, Messmer EM, Schubert C et al. Immunolocalization of defensins and cathelicidin in human glands of Moll. Ann Anat 2008 190 : 230 237.
14. Fulton C, Anderson GM, Zasloff M et al. Expression of natural peptide antibiotics in human skin. Lancet 1997 350 : 1750 1751.
15. Madsen P, Rasmussen HH, Leffers H et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. J Invest Dermatol 1991 97 : 701 712.
16. Michalek M, Gelhaus C, Hecht O et al. The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes. Dev Comp Immunol 2009 33 : 740 746.
17. Wolf R, Howard OM, Dong HF et al. Chemotactic activity of S100A7 (psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol 2008 181 : 1499 1506.
18. Rennie J, Arnt L, Tang H et al. Simple oligomers as antimicrobial peptide mimics. J Ind Microbiol Biotechnol 2005 32 : 296 300.
19. Vaara M. New approaches in peptide antibiotics. Curr Opin Pharmacol 2009 9 : 571 576.
20. Tew GN, Scott RW, Klein ML, Degrado WF. De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Acc Chem Res 2010 43 : 30 9.
21. Zhao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996 396 : 319 322.
22. Sorensen OE, Thapa DR, Rosenthal A et al. Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 2005 174 : 4870 4879.
23. Liu AY, Destoumieux D, Wong AV et al. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002 118 : 275 281.
24. Yang D, Chertov O, Bykovskaia SN et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999 286 : 525 528.
25. Hirsch T, Spielmann M, Zuhaili B et al. Human beta-defensin-3 promotes wound healing in infected diabetic wounds. J Gene Med 2009 11 : 220 228.
26. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol 1995 32 : 982 986.
27. Butmarc J, Yufit T, Carson P, Falanga V. Human beta-defensin-2 expression is increased in chronic wounds. Wound Repair Regen 2004 12 : 439 443.
28. Milner SM, Ortega MR. Reduced antimicrobial peptide expression in human burn wounds. Burns 1999 25 : 411 413.
29. Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis 2008 47 : 1537 1545.
30. Steinstraesser L, Kraneburg UM, Hirsch T et al. Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance? Int J Mol Sci 2009 10 : 3951 3970.
31. Giacometti A, Ghiselli R, Cirioni O et al. Therapeutic efficacy of the magainin analogue MSI-78 in different intra-abdominal sepsis rat models. J Antimicrob Chemother 2004 54 : 654 660.
32. Gopinath D, Kumar MS, Selvaraj D, Jayakumar R. Pexiganan-incorporated collagen matrices for infected wound-healing processes in rat. J Biomed Mater Res A 2005 73 : 320 331.
33. Dressel S, Harder J, Cordes J et al. Differential expression of antimicrobial peptides in margins of chronic wounds. Exp Dermatol 2010 Jan 19 [Epub ahead of print].