Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

Cell Cycle

Volumn 11, Issue 16, 2012, Pages 3132-3140

  McKenna, Elise ^a   Traganos, Frank ^a   Zhao, Hong ^a   Darzynkiewicz, Zbigniew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Cell cycle; Human non small cell lung carcinoma; Metronomic chemotherapy; mTOR; Oncogenes; Personalized cancer treatment; Senescence; H2AX

Indexed keywords

HISTONE H2AX; MAMMALIAN TARGET OF RAPAMYCIN; MITOMYCIN C; PROTEIN P21;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL AGING; CELL LEVEL; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA REPLICATION; DRUG EFFECT; DRUG EXPOSURE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION;

EID: 84865325090     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.21506     Document Type: Article

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