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Volumn 103, Issue , 2011, Pages 149-188

Fluorescence-Based Detection and Quantification of Features of Cellular Senescence

Author keywords

Doubling capacity; Dynamics; Membrane potential; Replicative; Superoxide; Telomere

Indexed keywords

BETA GALACTOSIDASE; H2AFX PROTEIN, HUMAN; HISTONE; HYDROXYL RADICAL; LIPOFUSCIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TUMOR SUPPRESSOR PROTEIN;

EID: 79959695728     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385493-3.00007-3     Document Type: Book
Times cited : (42)

References (191)
  • 1
    • 70349773104 scopus 로고    scopus 로고
    • Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    • Adams P.D. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 2009, 36:2-14.
    • (2009) Mol. Cell , vol.36 , pp. 2-14
    • Adams, P.D.1
  • 2
    • 0000086787 scopus 로고
    • Vital staining and fluorescence microscopy of lysosomes
    • North-Holland Publishing Co., Amsterdam
    • Allison A.C., Young M.R. Vital staining and fluorescence microscopy of lysosomes. Lysosomes in Biology and Pathology 1969, Vol. 2:600-628. North-Holland Publishing Co., Amsterdam.
    • (1969) Lysosomes in Biology and Pathology , vol.2 , pp. 600-628
    • Allison, A.C.1    Young, M.R.2
  • 3
    • 84925548155 scopus 로고    scopus 로고
    • Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls
    • Baerlocher G., Mak M.J., Tien T., Lansdorp P.M. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 2002, 47:89-99.
    • (2002) Cytometry , vol.47 , pp. 89-99
    • Baerlocher, G.1    Mak, M.J.2    Tien, T.3    Lansdorp, P.M.4
  • 4
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 5
    • 0036545818 scopus 로고    scopus 로고
    • Determination of mitochondrial reactive oxygen species: methodological aspects
    • Batandier C., Fontaine E., Kériel C., Leverve X.M. Determination of mitochondrial reactive oxygen species: methodological aspects. J. Cell. Mol. Med. 2002, 6:175-187.
    • (2002) J. Cell. Mol. Med. , vol.6 , pp. 175-187
    • Batandier, C.1    Fontaine, E.2    Kériel, C.3    Leverve, X.M.4
  • 6
    • 0024951774 scopus 로고
    • Compared flow cytometric analysis of mitochondria using 10-n-nonyl acridine orange and rhodamine 123
    • Benel L., Ronot X., Mounolou J.C., Gaudemer F., Adolphe M. Compared flow cytometric analysis of mitochondria using 10-n-nonyl acridine orange and rhodamine 123. Basic Appl. Histochem. 1989, 33:71-80.
    • (1989) Basic Appl. Histochem. , vol.33 , pp. 71-80
    • Benel, L.1    Ronot, X.2    Mounolou, J.C.3    Gaudemer, F.4    Adolphe, M.5
  • 7
    • 0032211437 scopus 로고    scopus 로고
    • Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
    • Benov L., Sztejnberg L., Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic. Biol. Med. 1998, 25:826-831.
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 826-831
    • Benov, L.1    Sztejnberg, L.2    Fridovich, I.3
  • 8
    • 0023465842 scopus 로고
    • Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells
    • Beregi E., Regius O. Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells. Acta Morphol. Hung. 1987, 35:219-224.
    • (1987) Acta Morphol. Hung. , vol.35 , pp. 219-224
    • Beregi, E.1    Regius, O.2
  • 9
    • 35948982621 scopus 로고    scopus 로고
    • The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction
    • Bergamini E., Cavallini G., Donati A., Gori Z. The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann. N. Y. Acad. Sci. 2007, 1114:69-78.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1114 , pp. 69-78
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 10
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny M.V. Aging: ROS or TOR. Cell Cycle 2008, 7:3344-3354.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 12
    • 0003097634 scopus 로고    scopus 로고
    • Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders
    • Bota D.A., Davies K.J.A. Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders. Mitochondrion 2001, 1:33-49.
    • (2001) Mitochondrion , vol.1 , pp. 33-49
    • Bota, D.A.1    Davies, K.J.A.2
  • 14
    • 0002844195 scopus 로고
    • Synthesis of diacetyldichlorofluorescin: a stable reagent for fluorometric analysis
    • Brandt R., Keston A.S. Synthesis of diacetyldichlorofluorescin: a stable reagent for fluorometric analysis. Anal. Biochem. 1965, 11:6-9.
    • (1965) Anal. Biochem. , vol.11 , pp. 6-9
    • Brandt, R.1    Keston, A.S.2
  • 15
    • 0036710928 scopus 로고    scopus 로고
    • Lipofuscin: mechanisms of age-related accumulation and influence on cell function
    • Brunk U.T., Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic. Biol. Med. 2002, 33:611-619.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 611-619
    • Brunk, U.T.1    Terman, A.2
  • 16
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    • Brunk U.T., Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 2002, 269:1996-2002.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 17
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
    • Brunk U.T., Jones C.B., Sohal R.S. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat. Res. 1992, 275:395-403.
    • (1992) Mutat. Res. , vol.275 , pp. 395-403
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 18
    • 0022519244 scopus 로고
    • Uptake and accumulation of the vital dye hydroethidine in neoplastic cells
    • Bucana C., Saiki I., Nayar R. Uptake and accumulation of the vital dye hydroethidine in neoplastic cells. J. Histochem. Cytochem. 1986, 34:1109-1115.
    • (1986) J. Histochem. Cytochem. , vol.34 , pp. 1109-1115
    • Bucana, C.1    Saiki, I.2    Nayar, R.3
  • 19
    • 0018075201 scopus 로고
    • Uptake and intracellular distribution of neutral red in cultured fibroblasts
    • Bulychev A., Trouet A., Tulkens P. Uptake and intracellular distribution of neutral red in cultured fibroblasts. Exp. Cell Res. 1978, 115:343-355.
    • (1978) Exp. Cell Res. , vol.115 , pp. 343-355
    • Bulychev, A.1    Trouet, A.2    Tulkens, P.3
  • 20
    • 33846334501 scopus 로고    scopus 로고
    • Oncogene-induced senescence pathways weave an intricate tapestry
    • Campisi J. Oncogene-induced senescence pathways weave an intricate tapestry. Cell 2007, 128:233-234.
    • (2007) Cell , vol.128 , pp. 233-234
    • Campisi, J.1
  • 21
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 22
    • 0034774859 scopus 로고    scopus 로고
    • Cellular senescence, cancer and aging: the telomere connection
    • Campisi J., Kim S.H., Lim C.S., Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp. Gerontol. 2001, 36:1619-1637.
    • (2001) Exp. Gerontol. , vol.36 , pp. 1619-1637
    • Campisi, J.1    Kim, S.H.2    Lim, C.S.3    Rubio, M.4
  • 23
    • 0024483266 scopus 로고
    • Fluorescent labeling of mitochondria
    • Chen L.B. Fluorescent labeling of mitochondria. Methods Cell Biol. 1989, 29:103-123.
    • (1989) Methods Cell Biol. , vol.29 , pp. 103-123
    • Chen, L.B.1
  • 24
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Chen Q., Ames B.N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:4130-4134.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 25
    • 0034472888 scopus 로고    scopus 로고
    • Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide
    • Chen Q.M., Tu V.C., Catania J., Burton M., Toussaint O., Dilley T. Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J. Cell Sci. 2000, 113:4087-4097.
    • (2000) J. Cell Sci. , vol.113 , pp. 4087-4097
    • Chen, Q.M.1    Tu, V.C.2    Catania, J.3    Burton, M.4    Toussaint, O.5    Dilley, T.6
  • 27
    • 0023732274 scopus 로고
    • A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals
    • Chevion M. A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals. Free Radic. Biol. Med. 1988, 5:27-37.
    • (1988) Free Radic. Biol. Med. , vol.5 , pp. 27-37
    • Chevion, M.1
  • 28
    • 0036203197 scopus 로고    scopus 로고
    • Markers of senescence?
    • Coates P.J. Markers of senescence?. J. Pathol. 2002, 196:371-373.
    • (2002) J. Pathol. , vol.196 , pp. 371-373
    • Coates, P.J.1
  • 29
    • 0017188298 scopus 로고
    • Characterization of residual bodies formed in phase II cultivated human glial cells
    • Collins V.P., Brunk U.T. Characterization of residual bodies formed in phase II cultivated human glial cells. Mech. Ageing Dev. 1976, 5:193-207.
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 193-207
    • Collins, V.P.1    Brunk, U.T.2
  • 30
    • 0014831743 scopus 로고
    • Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth
    • Comings D.E., Okada T.A. Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth. Exp. Cell Res. 1970, 61:295-301.
    • (1970) Exp. Cell Res. , vol.61 , pp. 295-301
    • Comings, D.E.1    Okada, T.A.2
  • 32
    • 0030917307 scopus 로고    scopus 로고
    • Peptide nucleic acids: expanding the scope of nucleic acid recognition
    • Corey D.R. Peptide nucleic acids: expanding the scope of nucleic acid recognition. Trends Biotechnol. 1997, 15:224-229.
    • (1997) Trends Biotechnol. , vol.15 , pp. 224-229
    • Corey, D.R.1
  • 33
    • 0027374638 scopus 로고
    • A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
    • Cossarizza A., Baccarani-Contri M., Kalashnikova G., Franceschi C. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem. Biophys. Res. Commun. 1993, 197:40-45.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 40-45
    • Cossarizza, A.1    Baccarani-Contri, M.2    Kalashnikova, G.3    Franceschi, C.4
  • 35
    • 26244436644 scopus 로고    scopus 로고
    • SA β-Gal staining: biomarker or delusion
    • Cristofalo V.J. SA β-Gal staining: biomarker or delusion. Exp. Gerontol. 2005, 40:836-838.
    • (2005) Exp. Gerontol. , vol.40 , pp. 836-838
    • Cristofalo, V.J.1
  • 36
    • 84941325677 scopus 로고
    • Cell size and nucleic acid content in the diploid human cell line WI-38 during aging
    • Cristofalo V.J., Kritchevsky D. Cell size and nucleic acid content in the diploid human cell line WI-38 during aging. Med. Exp. Int. J. Exp. Med. 1969, 19:313-320.
    • (1969) Med. Exp. Int. J. Exp. Med. , vol.19 , pp. 313-320
    • Cristofalo, V.J.1    Kritchevsky, D.2
  • 37
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperone-mediated autophagy
    • Cuervo A.M., Dice J.F. Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 2000, 275:31505-31513.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 38
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene 2002, 21:532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • de Lange, T.1
  • 39
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: the senescence connection
    • Deng Y., Chan S.S., Chang S. Telomere dysfunction and tumour suppression: the senescence connection. Nat. Rev. Cancer 2008, 8:450-458.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 41
    • 0021189636 scopus 로고
    • Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies
    • De Priester W., Van Manen R., Knook D.L. Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies. Mech. Ageing Dev. 1984, 26:205-216.
    • (1984) Mech. Ageing Dev. , vol.26 , pp. 205-216
    • De Priester, W.1    Van Manen, R.2    Knook, D.L.3
  • 43
    • 38149103006 scopus 로고    scopus 로고
    • High NaCl promotes cellular senescence
    • Dmitrieva N.I., Burg M.B. High NaCl promotes cellular senescence. Cell Cycle 2007, 6:3108-3113.
    • (2007) Cell Cycle , vol.6 , pp. 3108-3113
    • Dmitrieva, N.I.1    Burg, M.B.2
  • 44
    • 0019615725 scopus 로고
    • Quantitative studies of the autofluorescence derived from neuronal lipofuscin
    • Dowson J.H., Harris S.J. Quantitative studies of the autofluorescence derived from neuronal lipofuscin. J. Microsc. 1981, 123:249-258.
    • (1981) J. Microsc. , vol.123 , pp. 249-258
    • Dowson, J.H.1    Harris, S.J.2
  • 45
    • 0023814969 scopus 로고
    • Fluorophores of the human retinal pigment epithelium: separation and spectral characterization
    • Eldred G.E., Katz M.L. Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp. Eye Res. 1988, 47:71-86.
    • (1988) Exp. Eye Res. , vol.47 , pp. 71-86
    • Eldred, G.E.1    Katz, M.L.2
  • 46
    • 0020323939 scopus 로고
    • Lipofuscin: resolution of discrepant fluorescence data
    • Eldred G.E., Miller G.V., Stark W.S., Feeney-Burns L. Lipofuscin: resolution of discrepant fluorescence data. Science 1982, 216:757-759.
    • (1982) Science , vol.216 , pp. 757-759
    • Eldred, G.E.1    Miller, G.V.2    Stark, W.S.3    Feeney-Burns, L.4
  • 48
    • 0028838494 scopus 로고
    • Rhodamine 123: a useful probe for monitoring T cell activation
    • Ferlini C., Biselli R., Nisini R., Fattorossi A. Rhodamine 123: a useful probe for monitoring T cell activation. Cytometry 1995, 21:284-293.
    • (1995) Cytometry , vol.21 , pp. 284-293
    • Ferlini, C.1    Biselli, R.2    Nisini, R.3    Fattorossi, A.4
  • 49
    • 0025856351 scopus 로고
    • Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs
    • Fiering S.N., Roederer M., Nolan G.P., Micklem D.R., Parks D.R., Herzenberg L.A. Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 1991, 12:291-301.
    • (1991) Cytometry , vol.12 , pp. 291-301
    • Fiering, S.N.1    Roederer, M.2    Nolan, G.P.3    Micklem, D.R.4    Parks, D.R.5    Herzenberg, L.A.6
  • 50
    • 44349184864 scopus 로고    scopus 로고
    • Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation
    • Fu X., Wan S., Lyu Y.L., Liu L.F., Qi H. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS ONE 2008, 3:e2009.
    • (2008) PLoS ONE , vol.3
    • Fu, X.1    Wan, S.2    Lyu, Y.L.3    Liu, L.F.4    Qi, H.5
  • 51
    • 0028788763 scopus 로고
    • Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-B: studies with isolated mitochondria and rat hepatocytes
    • Garcia-Ruiz C., Colell A., Morales A., Kaplowitz N., Fernandez-Checa J.C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 1995, 48:825-834.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 825-834
    • Garcia-Ruiz, C.1    Colell, A.2    Morales, A.3    Kaplowitz, N.4    Fernandez-Checa, J.C.5
  • 53
    • 39749136529 scopus 로고    scopus 로고
    • Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors
    • Görlach A., Kietzmann T. Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. Methods Enzymol 2007, 435:421-446.
    • (2007) Methods Enzymol , vol.435 , pp. 421-446
    • Görlach, A.1    Kietzmann, T.2
  • 55
    • 0033569943 scopus 로고    scopus 로고
    • Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays
    • Hacia J.G., Novotny E.A., Mayer R.A., Woski S.A., Ashlock M.A., Collins F.S. Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays. Nucleic Acids Res. 1999, 27:4034-4039.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4034-4039
    • Hacia, J.G.1    Novotny, E.A.2    Mayer, R.A.3    Woski, S.A.4    Ashlock, M.A.5    Collins, F.S.6
  • 58
    • 79959762911 scopus 로고
    • TELORUN for Excel. Ver 1.4 For Analysis of mean TRF length. Geron Corporation.
    • Harley, C., Allsopp, R., and Vaziri, H. (1995). TELORUN for Excel. Ver 1.4 For Analysis of mean TRF length. Geron Corporation.
    • (1995)
    • Harley, C.1    Allsopp, R.2    Vaziri, H.3
  • 59
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 60
    • 0015319592 scopus 로고
    • The biologic clock: the mitochondria?
    • Harman D. The biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 1972, 20:145-147.
    • (1972) J. Am. Geriatr. Soc. , vol.20 , pp. 145-147
    • Harman, D.1
  • 61
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 1965, 37:614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 62
    • 0019203659 scopus 로고
    • Recent advances in the cell biology of aging
    • Hayflick L. Recent advances in the cell biology of aging. Mech. Ageing Dev. 1980, 14:59-79.
    • (1980) Mech. Ageing Dev. , vol.14 , pp. 59-79
    • Hayflick, L.1
  • 64
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
    • Herbig U., Jobling W.A., Chen B.P.C., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a. Mol. Cell 2004, 14:501-513.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.C.3    Chen, D.J.4    Sedivy, J.M.5
  • 65
    • 0027430156 scopus 로고
    • Dihydrorhodamine 123: a fluorescent probe for superoxide generation?
    • Henderson L.M., Chappell J.B. Dihydrorhodamine 123: a fluorescent probe for superoxide generation?. Eur. J. Biochem. 1993, 217:973-980.
    • (1993) Eur. J. Biochem. , vol.217 , pp. 973-980
    • Henderson, L.M.1    Chappell, J.B.2
  • 66
    • 0000217378 scopus 로고
    • A new class of uncoupling agents: carbonyl cyanide phenylhydrazones
    • Heytler Prichard
    • Heytler, Prichard A new class of uncoupling agents: carbonyl cyanide phenylhydrazones. Biochem. Biophys. Res. Comm. 1962, 7:272.
    • (1962) Biochem. Biophys. Res. Comm. , vol.7 , pp. 272
  • 67
    • 0036814967 scopus 로고    scopus 로고
    • Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress
    • Hutter E., Unterluggauer H., Uberall F., Schramek H., Jansen-Durr P. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress. Exp. Gerontol. 2002, 37:1165-11674.
    • (2002) Exp. Gerontol. , vol.37 , pp. 1165-11674
    • Hutter, E.1    Unterluggauer, H.2    Uberall, F.3    Schramek, H.4    Jansen-Durr, P.5
  • 68
    • 67650828068 scopus 로고    scopus 로고
    • A comparative analysis of the cell biology of senescence and aging
    • Hwang E.S., Yoon G., Kang H.T. A comparative analysis of the cell biology of senescence and aging. Cell. Mol. Life Sci. 2009, 66:2503-2524.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2503-2524
    • Hwang, E.S.1    Yoon, G.2    Kang, H.T.3
  • 69
    • 77955276502 scopus 로고    scopus 로고
    • Organellar vs. cellular control of mitochondrial dynamics
    • Hyde B.B., Twig G., Shirihai O.S. Organellar vs. cellular control of mitochondrial dynamics. Semin. Cell Dev. Biol. 2010, 21:575-581.
    • (2010) Semin. Cell Dev. Biol. , vol.21 , pp. 575-581
    • Hyde, B.B.1    Twig, G.2    Shirihai, O.S.3
  • 70
    • 79251574964 scopus 로고    scopus 로고
    • Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation
    • Kim I., Lemasters J.J. Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am. J. Physiol. Cell Physiol. 2011, 300:C308-C317. http://www.ncbi.nlm.nih.gov/pubmed/21106691.
    • (2011) Am. J. Physiol. Cell Physiol. , vol.300
    • Kim, I.1    Lemasters, J.J.2
  • 71
    • 79959766852 scopus 로고    scopus 로고
    • Invitrogen. Probes for MitochondriaMolecular Probes Handbook, a guide to fluorescent porobes and labeling technologies. 11th ed. Section 12.2. Available at. ().
    • Invitrogen. (2010). Probes for MitochondriaMolecular Probes Handbook, a guide to fluorescent porobes and labeling technologies. 11th ed. Section 12.2. Available at. (). http://www.invitrogen.com/site/us/en/home/References/Molecular-Probes-The-Handbook/Probes-for-Organelles/Probes-for-Mitochondria.html.
    • (2010)
  • 72
    • 79959750782 scopus 로고    scopus 로고
    • Fluorogenic Detection of Mitochondrial Superoxide in Live Cells.
    • The American Society for Cell Biology 44th Annual Meeting, Washington, DC. December 4-8, 2004.
    • Janes, M. S., Hill, D. M., Cardon, C. M., Robinson, K. M., Walls, J. R., Leung, W. Y., Beckman, J. S., and Ignatius, M. J. (2004). Fluorogenic Detection of Mitochondrial Superoxide in Live Cells. The American Society for Cell Biology 44th Annual Meeting, Washington, DC. December 4-8, 2004.
    • (2004)
    • Janes, M.S.1    Hill, D.M.2    Cardon, C.M.3    Robinson, K.M.4    Walls, J.R.5    Leung, W.Y.6    Beckman, J.S.7    Ignatius, M.J.8
  • 74
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 75
    • 0007574262 scopus 로고
    • Localization of mitochondria in living cells with rhodamine 123
    • Johnson L.V., Walsh M.L., Chen L.B. Localization of mitochondria in living cells with rhodamine 123. Proc. Natl. Acad. Sci. U.S.A. 1980, 77:990-994.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 990-994
    • Johnson, L.V.1    Walsh, M.L.2    Chen, L.B.3
  • 76
    • 33847184227 scopus 로고    scopus 로고
    • Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence
    • Johung K., Goodwin E.C., DiMaio D. Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 2007, 81:2102-2116.
    • (2007) J. Virol. , vol.81 , pp. 2102-2116
    • Johung, K.1    Goodwin, E.C.2    DiMaio, D.3
  • 77
    • 67651183851 scopus 로고    scopus 로고
    • Nicotinamide enhances mitochondria quality through autophagy activation in human cells
    • Kang H.T., Hwang E.S. Nicotinamide enhances mitochondria quality through autophagy activation in human cells. Aging Cell 2009, 8:426-438.
    • (2009) Aging Cell , vol.8 , pp. 426-438
    • Kang, H.T.1    Hwang, E.S.2
  • 78
    • 33748306003 scopus 로고    scopus 로고
    • Nicotinamide extends replicative lifespan of human cells
    • Kang H.T., Lee H.I., Hwang E.S. Nicotinamide extends replicative lifespan of human cells. Aging Cell 2006, 5:423-436.
    • (2006) Aging Cell , vol.5 , pp. 423-436
    • Kang, H.T.1    Lee, H.I.2    Hwang, E.S.3
  • 79
    • 34247490248 scopus 로고    scopus 로고
    • Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications
    • Kaufmann A.M., Krise J.P. Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. J. Pharm. Sci. 2007, 96:729-746.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 729-746
    • Kaufmann, A.M.1    Krise, J.P.2
  • 80
    • 0034161442 scopus 로고    scopus 로고
    • TM green is affected by mitochondrial membrane potential altering drugs
    • TM green is affected by mitochondrial membrane potential altering drugs. Cytometry 2000, 39:203-210.
    • (2000) Cytometry , vol.39 , pp. 203-210
    • Keij, J.F.1    Bell-Prince, C.2    Steinkamp, J.A.3
  • 81
    • 0026445548 scopus 로고
    • A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen
    • Khan A.U., Mei Y.H., Wilson T. A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:11426-11427.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 11426-11427
    • Khan, A.U.1    Mei, Y.H.2    Wilson, T.3
  • 83
    • 0017149860 scopus 로고
    • Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats
    • Knook D.L., Sleyster E.C. Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats. Mech. Ageing Dev. 1976, 5:389-398.
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 389-398
    • Knook, D.L.1    Sleyster, E.C.2
  • 85
  • 86
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • Kurz D.J., Decary S., Hong Y., Erusalimsky J.D. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J. Cell Sci. 2000, 113:3613-3622.
    • (2000) J. Cell Sci. , vol.113 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 88
    • 0026554428 scopus 로고
    • Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
    • LeBel C.P., Ischiropoulos H., Bondy S.C. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 1992, 5:227-231.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 227-231
    • LeBel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 91
    • 0032429396 scopus 로고    scopus 로고
    • Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung
    • Lee H.C., Lu C.Y., Fahn H.J., Wei Y.H. Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett. 1998, 441:292-296.
    • (1998) FEBS Lett. , vol.441 , pp. 292-296
    • Lee, H.C.1    Lu, C.Y.2    Fahn, H.J.3    Wei, Y.H.4
  • 92
    • 0035685590 scopus 로고    scopus 로고
    • Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging
    • Lee H.C., Wei Y.H. Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2001, 2:231-244.
    • (2001) Biogerontology , vol.2 , pp. 231-244
    • Lee, H.C.1    Wei, Y.H.2
  • 93
    • 0036420161 scopus 로고    scopus 로고
    • Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
    • Lee H.C., Yin P.H., Chi C.W., Wei Y.H. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J. Biomed. Sci. 2002, 9:517-526.
    • (2002) J. Biomed. Sci. , vol.9 , pp. 517-526
    • Lee, H.C.1    Yin, P.H.2    Chi, C.W.3    Wei, Y.H.4
  • 94
    • 0034214103 scopus 로고    scopus 로고
    • Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
    • Lee H.C., Yin P.H., Lu C.Y., Chi C.W., Wei Y.H. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem. J. 2000, 348:425-432.
    • (2000) Biochem. J. , vol.348 , pp. 425-432
    • Lee, H.C.1    Yin, P.H.2    Lu, C.Y.3    Chi, C.W.4    Wei, Y.H.5
  • 96
    • 34547958816 scopus 로고    scopus 로고
    • Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
    • Lee S., Jeong S.Y., Lim W.C., Kim S., Park Y.Y., Sun X., Youle R.J., Cho H. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J. Biol. Chem. 2007, 282:22977-22983.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22977-22983
    • Lee, S.1    Jeong, S.Y.2    Lim, W.C.3    Kim, S.4    Park, Y.Y.5    Sun, X.6    Youle, R.J.7    Cho, H.8
  • 97
    • 0028109380 scopus 로고
    • Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles
    • Lezza A.M.S., Boffoli D., Scacco S., Cantatore P., Gadaleta M.N. Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biochem. Biophys. Res. Commun. 1994, 205:772-779.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , pp. 772-779
    • Lezza, A.M.S.1    Boffoli, D.2    Scacco, S.3    Cantatore, P.4    Gadaleta, M.N.5
  • 98
    • 0035854649 scopus 로고    scopus 로고
    • Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects
    • Lezza A.M.S., Pesce V., Cormio A., Fracasso F., Vecchiet J., Felzani G., Cantatore P., Gadaleta M.N. Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. FEBS Lett. 2001, 501:74-78.
    • (2001) FEBS Lett. , vol.501 , pp. 74-78
    • Lezza, A.M.S.1    Pesce, V.2    Cormio, A.3    Fracasso, F.4    Vecchiet, J.5    Felzani, G.6    Cantatore, P.7    Gadaleta, M.N.8
  • 99
    • 34548238224 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
    • Linge A., Weinhold K., Bläsche R., Kasper M., Barth K. Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells. Int. J. Biochem. Cell Biol. 2007, 39:1964-1974.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1964-1974
    • Linge, A.1    Weinhold, K.2    Bläsche, R.3    Kasper, M.4    Barth, K.5
  • 100
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease
    • Linnane A.W., Marzuki S., Ozawa T., Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease. Lancet 1989, 1(8639):642-645.
    • (1989) Lancet , vol.1 , Issue.8639 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 107
    • 0032780959 scopus 로고    scopus 로고
    • Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells
    • Minamikawa T., Sriratana A., Williams D.A., Bowser D.N., Hill J.S., Nagley P. Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells. J. Cell Sci. 1999, 112:2419-2430.
    • (1999) J. Cell Sci. , vol.112 , pp. 2419-2430
    • Minamikawa, T.1    Sriratana, A.2    Williams, D.A.3    Bowser, D.N.4    Hill, J.S.5    Nagley, P.6
  • 108
    • 0033614441 scopus 로고    scopus 로고
    • Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells
    • Miranda S., Foncea R., Guerrero J., Leighton F. Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells. Biochem. Biophys. Res. Commun. 1999, 258:44-49.
    • (1999) Biochem. Biophys. Res. Commun. , vol.258 , pp. 44-49
    • Miranda, S.1    Foncea, R.2    Guerrero, J.3    Leighton, F.4
  • 110
    • 33748422079 scopus 로고    scopus 로고
    • Oncogene-induced cell senescence: halting on the road to cancer
    • Mooi W.J., Peeper D.S. Oncogene-induced cell senescence: halting on the road to cancer. N. Engl. J. Med. 2006, 355:1037-1046.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1037-1046
    • Mooi, W.J.1    Peeper, D.S.2
  • 111
    • 0037718255 scopus 로고    scopus 로고
    • Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation
    • Myhre O., Andersen J.M., Aarnes H., Fonnum F. Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem. Pharmacol. 2003, 65:1575-1582.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1575-1582
    • Myhre, O.1    Andersen, J.M.2    Aarnes, H.3    Fonnum, F.4
  • 112
    • 33746752125 scopus 로고    scopus 로고
    • A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation
    • Narita M., Narita M., Krizhanovsky V., Nunez S., Chicas A., Hearn S.A., Myers M.P., Lowe S.W. A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation. Cell 2006, 126:503-514.
    • (2006) Cell , vol.126 , pp. 503-514
    • Narita, M.1    Narita, M.2    Krizhanovsky, V.3    Nunez, S.4    Chicas, A.5    Hearn, S.A.6    Myers, M.P.7    Lowe, S.W.8
  • 114
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • Navarro A., Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 2007, 292:C670-C686.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292
    • Navarro, A.1    Boveris, A.2
  • 115
    • 0032925881 scopus 로고    scopus 로고
    • Applications of peptide nucleic acids
    • Nielsen P.E. Applications of peptide nucleic acids. Curr. Opin. Biotechnol. 1999, 10:71-75.
    • (1999) Curr. Opin. Biotechnol. , vol.10 , pp. 71-75
    • Nielsen, P.E.1
  • 116
    • 0034788516 scopus 로고    scopus 로고
    • Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts
    • Nishio K., Inoue A., Qiao S., Kondo H., Mimura A. Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts. Histochem. Cell Biol. 2001, 116:321-327.
    • (2001) Histochem. Cell Biol. , vol.116 , pp. 321-327
    • Nishio, K.1    Inoue, A.2    Qiao, S.3    Kondo, H.4    Mimura, A.5
  • 117
    • 0023989715 scopus 로고
    • Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-d-galactosidase activity after transduction of Escherichia coli lacZ
    • Nolan G.P., Fiering S., Nicolas J.F., Herzenberg L.A. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-d-galactosidase activity after transduction of Escherichia coli lacZ. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:2603-2607.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 2603-2607
    • Nolan, G.P.1    Fiering, S.2    Nicolas, J.F.3    Herzenberg, L.A.4
  • 118
    • 73149108205 scopus 로고    scopus 로고
    • Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle
    • O'Connell K., Ohlendieck K. Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle. Proteomics 2009, 9:5509-5524.
    • (2009) Proteomics , vol.9 , pp. 5509-5524
    • O'Connell, K.1    Ohlendieck, K.2
  • 119
    • 65349126392 scopus 로고    scopus 로고
    • Cellular senescence: its role in tumor suppression and aging
    • Ohtani N., Mann D.J., Hara E. Cellular senescence: its role in tumor suppression and aging. Cancer Sci. 2009, 100:792-797.
    • (2009) Cancer Sci. , vol.100 , pp. 792-797
    • Ohtani, N.1    Mann, D.J.2    Hara, E.3
  • 120
    • 30544445468 scopus 로고    scopus 로고
    • Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
    • Ota H., Tokunaga E., Chang K., Hikasa M., Iijima K., Eto M., Kozaki K., Akishita M., Ouchi Y., Kaneki M. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006, 25:176-185.
    • (2006) Oncogene , vol.25 , pp. 176-185
    • Ota, H.1    Tokunaga, E.2    Chang, K.3    Hikasa, M.4    Iijima, K.5    Eto, M.6    Kozaki, K.7    Akishita, M.8    Ouchi, Y.9    Kaneki, M.10
  • 121
    • 0017405185 scopus 로고
    • Low oxygen concentration extends the lifespan of cultured human diploid cells
    • Packer L., Fuehr K. Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 1977, 267:423-425.
    • (1977) Nature , vol.267 , pp. 423-425
    • Packer, L.1    Fuehr, K.2
  • 122
    • 38549123398 scopus 로고    scopus 로고
    • Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence
    • Park J.H., Yi H.W., DiMaio D., Hwang E.S. Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence. Korean J. Genet. 2007, 29:521-527.
    • (2007) Korean J. Genet. , vol.29 , pp. 521-527
    • Park, J.H.1    Yi, H.W.2    DiMaio, D.3    Hwang, E.S.4
  • 124
    • 38349000967 scopus 로고    scopus 로고
    • Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells
    • Patschan S., Chen J., Gealekman O., Krupincza K., Wang M., Shu L., Shayman J.A., Goligorsky M.S. Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells. Am. J. Physiol. Renal. Physiol. 2008, 294:100-109.
    • (2008) Am. J. Physiol. Renal. Physiol. , vol.294 , pp. 100-109
    • Patschan, S.1    Chen, J.2    Gealekman, O.3    Krupincza, K.4    Wang, M.5    Shu, L.6    Shayman, J.A.7    Goligorsky, M.S.8
  • 125
    • 1542563727 scopus 로고    scopus 로고
    • The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
    • Perez-Campo R., Lopez-Torres M., Cadenas S., Rojas C., Barja G. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach. J. Comp. Physiol. 1998, 68:149-158.
    • (1998) J. Comp. Physiol. , vol.68 , pp. 149-158
    • Perez-Campo, R.1    Lopez-Torres, M.2    Cadenas, S.3    Rojas, C.4    Barja, G.5
  • 127
    • 0026742850 scopus 로고
    • 10-N-nonyl acridine orange interacts with cardiolipin and allows the quantification of the phospholipids in isolated mitochondria
    • Petit J.M., Maftah A., Ratinaud M.H., Julien R. 10-N-nonyl acridine orange interacts with cardiolipin and allows the quantification of the phospholipids in isolated mitochondria. Eur. J. Biochem. 1992, 209:267-273.
    • (1992) Eur. J. Biochem. , vol.209 , pp. 267-273
    • Petit, J.M.1    Maftah, A.2    Ratinaud, M.H.3    Julien, R.4
  • 128
    • 0011953689 scopus 로고
    • The microscopic differentiation of the colour of formaldehyde-induced fluorescence
    • Ploem J.S. The microscopic differentiation of the colour of formaldehyde-induced fluorescence. Progr. Brain Res. 1971, 34:27-37.
    • (1971) Progr. Brain Res. , vol.34 , pp. 27-37
    • Ploem, J.S.1
  • 129
    • 0033178240 scopus 로고    scopus 로고
    • Telomere length measurements using digital fluorescence microscopy
    • Poon S.S., Martens U.M., Ward R.K., Lansdorp P.M. Telomere length measurements using digital fluorescence microscopy. Cytometry 1999, 36:267-278.
    • (1999) Cytometry , vol.36 , pp. 267-278
    • Poon, S.S.1    Martens, U.M.2    Ward, R.K.3    Lansdorp, P.M.4
  • 131
    • 0003017930 scopus 로고
    • Differential features between lipofuscin (age pigment) and various experimentally produced " ceroid pigments."
    • Excerpta Medica, Amsterdam, I. Zs.-Nagy (Ed.)
    • Porta E.A., Mower H.F., Moroye M., Lee C., Palimbo N.E. Differential features between lipofuscin (age pigment) and various experimentally produced " ceroid pigments." Lipofuscin - 1987: Stale of the Art 1988, Excerpta Medica, Amsterdam, pp. 341-374. I. Zs.-Nagy (Ed.).
    • (1988) Lipofuscin - 1987: Stale of the Art , pp. 341-374
    • Porta, E.A.1    Mower, H.F.2    Moroye, M.3    Lee, C.4    Palimbo, N.E.5
  • 132
    • 0020030177 scopus 로고
    • Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heart
    • Porta E.A., Sablan H.M., Joun N.S., Chee G. Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heart. Mech. Ageing Dev. 1982, 18:159-199.
    • (1982) Mech. Ageing Dev. , vol.18 , pp. 159-199
    • Porta, E.A.1    Sablan, H.M.2    Joun, N.S.3    Chee, G.4
  • 133
  • 135
    • 0023903701 scopus 로고
    • In situ cytometric analysis of nonyl acridine orange-stained mitochondria from splenocytes
    • Ratinaud M.H., Leprat P., Julien R. In situ cytometric analysis of nonyl acridine orange-stained mitochondria from splenocytes. Cytometry 1988, 9:206-212.
    • (1988) Cytometry , vol.9 , pp. 206-212
    • Ratinaud, M.H.1    Leprat, P.2    Julien, R.3
  • 137
    • 0014800006 scopus 로고
    • Morphologic changes accompanying senescence of cultured human diploid cells
    • Robbins E., Levine E.M., Eagle H. Morphologic changes accompanying senescence of cultured human diploid cells. J. Exp. Med. 1970, 131:1211-1222.
    • (1970) J. Exp. Med. , vol.131 , pp. 1211-1222
    • Robbins, E.1    Levine, E.M.2    Eagle, H.3
  • 139
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles S.J., Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998, 16:1113-1123.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 140
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 1999, 146:905-916.
    • (1999) J. Cell Biol. , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 142
    • 0025218905 scopus 로고
    • Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin
    • Rothe G., Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J. Leukoc. Biol. 1990, 47:440-448.
    • (1990) J. Leukoc. Biol. , vol.47 , pp. 440-448
    • Rothe, G.1    Valet, G.2
  • 143
    • 0031879115 scopus 로고    scopus 로고
    • Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
    • Rufer N., Dragowska W., Thornbury G., Roosnek E., Lansdorp P.M. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 1998, 16:743-747.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 743-747
    • Rufer, N.1    Dragowska, W.2    Thornbury, G.3    Roosnek, E.4    Lansdorp, P.M.5
  • 144
    • 0017751995 scopus 로고
    • Ultrastructure of the aging myocardium: a morphometric approach
    • Sachs H.G., Colgan J.A., Lazarus M.L. Ultrastructure of the aging myocardium: a morphometric approach. Am. J. Anat. 1977, 150:63-71.
    • (1977) Am. J. Anat. , vol.150 , pp. 63-71
    • Sachs, H.G.1    Colgan, J.A.2    Lazarus, M.L.3
  • 145
    • 0030612749 scopus 로고    scopus 로고
    • JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
    • Salvioli S., Ardizzoni A., Franceschi C., Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997, 411:77-82.
    • (1997) FEBS Lett. , vol.411 , pp. 77-82
    • Salvioli, S.1    Ardizzoni, A.2    Franceschi, C.3    Cossarizza, A.4
  • 146
    • 0013239134 scopus 로고    scopus 로고
    • Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages
    • Sanchez-Martin M.M., Cabezas J.A. Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages. Mech. Ageing Dev. 1997, 99:95-107.
    • (1997) Mech. Ageing Dev. , vol.99 , pp. 95-107
    • Sanchez-Martin, M.M.1    Cabezas, J.A.2
  • 147
    • 33748331132 scopus 로고    scopus 로고
    • Progressive loss of SIRT1 with cell cycle withdrawal
    • Sasaki T., Maier B., Bartke A., Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 2006, 5:413-422.
    • (2006) Aging Cell , vol.5 , pp. 413-422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3    Scrable, H.4
  • 148
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • Scaffidi P., Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006, 312:1059-1063.
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 149
    • 0036123267 scopus 로고    scopus 로고
    • Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective
    • Schmucker D.L., Sachs H. Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective. Arch. Gerontol. Geriatr. 2002, 34:249-261.
    • (2002) Arch. Gerontol. Geriatr. , vol.34 , pp. 249-261
    • Schmucker, D.L.1    Sachs, H.2
  • 152
    • 0021906664 scopus 로고
    • Hydrophobic acridine dyes for fluorescent staining of mitochondria in living cells. 3. Specific accumulation of the fluorescent dye NAO on the mitochondrial membranes in HeLa cells by hydrophobic interaction. Depression of respiratory activity changes in the ultrastructure of mitochondria due to NAO. Increase of fluorescence in vital stained mitochondria in situ by irradiation
    • Septinus M., Berthold T., Naujok A., Zimmerman H.W. Hydrophobic acridine dyes for fluorescent staining of mitochondria in living cells. 3. Specific accumulation of the fluorescent dye NAO on the mitochondrial membranes in HeLa cells by hydrophobic interaction. Depression of respiratory activity changes in the ultrastructure of mitochondria due to NAO. Increase of fluorescence in vital stained mitochondria in situ by irradiation. Histochemistry 1985, 82:51-66.
    • (1985) Histochemistry , vol.82 , pp. 51-66
    • Septinus, M.1    Berthold, T.2    Naujok, A.3    Zimmerman, H.W.4
  • 153
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 154
    • 0030014750 scopus 로고    scopus 로고
    • Quantitative comparison of in situ lipofuscin concentration with soluble autofluorescence intensity in the crustacean brain
    • Sheehy M.R. Quantitative comparison of in situ lipofuscin concentration with soluble autofluorescence intensity in the crustacean brain. Exp. Gerontol. 1996, 31:421-432.
    • (1996) Exp. Gerontol. , vol.31 , pp. 421-432
    • Sheehy, M.R.1
  • 155
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells
    • Shvets E., Fass E., Elazar Z. Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 2008, 4:621-628.
    • (2008) Autophagy , vol.4 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 156
    • 0035092972 scopus 로고    scopus 로고
    • Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress
    • Sitte N., Merker K., Grune T., von Zglinicki T. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exp. Gerontol. 2001, 36:475-486.
    • (2001) Exp. Gerontol. , vol.36 , pp. 475-486
    • Sitte, N.1    Merker, K.2    Grune, T.3    von Zglinicki, T.4
  • 157
    • 0036259159 scopus 로고    scopus 로고
    • Relationship between in vivo age and in vitro aging: assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging
    • Smith J.R., Venable S., Roberts T.W., Metter E.J., Monticone R., Schneider E.L. Relationship between in vivo age and in vitro aging: assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging. J. Gerontol. A Biol. Sci. Med. Sci. 2002, 57:B239-B246.
    • (2002) J. Gerontol. A Biol. Sci. Med. Sci. , vol.57
    • Smith, J.R.1    Venable, S.2    Roberts, T.W.3    Metter, E.J.4    Monticone, R.5    Schneider, E.L.6
  • 158
    • 0024998688 scopus 로고
    • Lipofuscin as an indicator of oxidative stress and aging
    • Sohal R.S., Brunk U.T. Lipofuscin as an indicator of oxidative stress and aging. Adv. Exp. Med. Biol. 1989, 266:17-26.
    • (1989) Adv. Exp. Med. Biol. , vol.266 , pp. 17-26
    • Sohal, R.S.1    Brunk, U.T.2
  • 159
    • 0026023219 scopus 로고
    • Hydrogen peroxide release by mitochondria increases during aging
    • Sohal R.S., Sohal B.H. Hydrogen peroxide release by mitochondria increases during aging. Mech. Ageing Dev. 1991, 57:187-202.
    • (1991) Mech. Ageing Dev. , vol.57 , pp. 187-202
    • Sohal, R.S.1    Sohal, B.H.2
  • 160
    • 16244383882 scopus 로고    scopus 로고
    • Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis
    • Song Y.S., Lee B.Y., Hwang E.S. Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech. Ageing Dev. 2005, 126:580-590.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 580-590
    • Song, Y.S.1    Lee, B.Y.2    Hwang, E.S.3
  • 161
    • 76549152982 scopus 로고
    • On the histochemistry and ultrastructure of age pigment
    • Strehler B.L. On the histochemistry and ultrastructure of age pigment. Adv. Gerontol. Res. 1964, 18:343-384.
    • (1964) Adv. Gerontol. Res. , vol.18 , pp. 343-384
    • Strehler, B.L.1
  • 163
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann J.B., Smyth M.J. Immune surveillance of tumors. J. Clin. Invest. 2007, 117:1137-1146.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1137-1146
    • Swann, J.B.1    Smyth, M.J.2
  • 164
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H., Smogorzewska A., de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 2003, 13:1549-1556.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 165
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 1995, 41:319-326.
    • (1995) Gerontology , vol.41 , pp. 319-326
    • Terman, A.1
  • 166
    • 0042707790 scopus 로고    scopus 로고
    • Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis
    • Terman A., Dalen H., Eaton J.W., Neuzil J., Brunk U.T. Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp. Gerontol. 2003, 38:863-876.
    • (2003) Exp. Gerontol. , vol.38 , pp. 863-876
    • Terman, A.1    Dalen, H.2    Eaton, J.W.3    Neuzil, J.4    Brunk, U.T.5
  • 167
    • 0023184285 scopus 로고
    • Optimal conditions for the measurement of lipid peroxidation products (lipofuscin) in individual cultivated human glial and glioma cells
    • Thaw H.H. Optimal conditions for the measurement of lipid peroxidation products (lipofuscin) in individual cultivated human glial and glioma cells. Mech. Ageing Dev. 1987, 38:79-87.
    • (1987) Mech. Ageing Dev. , vol.38 , pp. 79-87
    • Thaw, H.H.1
  • 168
    • 0033732110 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    • Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 2000, 35:927-945.
    • (2000) Exp. Gerontol. , vol.35 , pp. 927-945
    • Toussaint, O.1    Medrano, E.E.2    von Zglinicki, T.3
  • 170
    • 0036176049 scopus 로고    scopus 로고
    • Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
    • Tu V.C., Bahl J.J., Chen Q.M. Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. J. Pharmacol. Exp. Ther. 2002, 300:1101-1110.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 1101-1110
    • Tu, V.C.1    Bahl, J.J.2    Chen, Q.M.3
  • 171
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens J.F. Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 1997, 17:3-8.
    • (1997) Biosci. Rep. , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 173
    • 0037335554 scopus 로고    scopus 로고
    • Telomere-driven replicative senescence is a stress response
    • Von Zglinicki T., Petrie J., Kirkwood T.B.L. Telomere-driven replicative senescence is a stress response. Nat. Biotechnol. 2003, 21:229-230.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 229-230
    • Von Zglinicki, T.1    Petrie, J.2    Kirkwood, T.B.L.3
  • 174
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
    • Von Zglinicki T., Saretzki G., Docke W., Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?. Exp. Cell Res. 1995, 220:186-193.
    • (1995) Exp. Cell Res. , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Docke, W.3    Lotze, C.4
  • 175
    • 0021179316 scopus 로고
    • Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro
    • Wang E., Gundersen D. Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro. Exp. Cell. Res. 1984, 154:191-202.
    • (1984) Exp. Cell. Res. , vol.154 , pp. 191-202
    • Wang, E.1    Gundersen, D.2
  • 176
    • 3042778581 scopus 로고    scopus 로고
    • 2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts
    • 2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp. Cell Res. 2004, 298:188-196.
    • (2004) Exp. Cell Res. , vol.298 , pp. 188-196
    • Wang, Y.1    Meng, A.2    Zhou, D.3
  • 177
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei Y.H. Oxidative stress and mitochondrial DNA mutations in human aging. Proc. Soc. Exp. Biol. Med. 1998, 217:53-63.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 178
    • 0035028669 scopus 로고    scopus 로고
    • Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4,977 BP-deleted mitochondrial DNA
    • Wei Y.H., Lee C.F., Lee H.C., Ma Y.S., Wang C.W., Lu C.Y., Pang C.Y. Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4,977 BP-deleted mitochondrial DNA. Ann. N.Y. Acad. Sci. 2001, 928:97-112.
    • (2001) Ann. N.Y. Acad. Sci. , vol.928 , pp. 97-112
    • Wei, Y.H.1    Lee, C.F.2    Lee, H.C.3    Ma, Y.S.4    Wang, C.W.5    Lu, C.Y.6    Pang, C.Y.7
  • 179
    • 0036790385 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
    • Wei Y.H., Lee H.C. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp. Biol. Med. (Maywood) 2002, 227:671-682.
    • (2002) Exp. Biol. Med. (Maywood) , vol.227 , pp. 671-682
    • Wei, Y.H.1    Lee, H.C.2
  • 180
    • 0030061844 scopus 로고    scopus 로고
    • Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells
    • Wersto R.P., Rosenthal E.R., Crystal R.G., Spring K.R. Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:1167-1172.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1167-1172
    • Wersto, R.P.1    Rosenthal, E.R.2    Crystal, R.G.3    Spring, K.R.4
  • 181
    • 0028114890 scopus 로고
    • The reaction of superoxide with reduced glutathione
    • Winterbourn C.C., Metodiewa D. The reaction of superoxide with reduced glutathione. Arch. Biochem. Biophys. 1994, 314:284-290.
    • (1994) Arch. Biochem. Biophys. , vol.314 , pp. 284-290
    • Winterbourn, C.C.1    Metodiewa, D.2
  • 182
    • 0034998914 scopus 로고    scopus 로고
    • Intracellular localization of the radiation enhancer motexafin gadolinium using interferometric Fourier fluorescence microscopy
    • Woodburn K.W. Intracellular localization of the radiation enhancer motexafin gadolinium using interferometric Fourier fluorescence microscopy. J. Pharmacol. Exp. Ther. 2001, 297:888-894.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 888-894
    • Woodburn, K.W.1
  • 183
    • 26244445013 scopus 로고    scopus 로고
    • The limitations and validities of senescence associated-[beta]-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells
    • Yang N.-C., Hum M.-L. The limitations and validities of senescence associated-[beta]-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp. Gerontol. 2005, 40:813-819.
    • (2005) Exp. Gerontol. , vol.40 , pp. 813-819
    • Yang, N.-C.1    Hum, M.-L.2
  • 184
    • 57049186623 scopus 로고    scopus 로고
    • How to live long and prosper: autophagy, mitochondria, and aging
    • Yen W.L., Klionsky D.J. How to live long and prosper: autophagy, mitochondria, and aging. Physiology 2008, 23:248-262.
    • (2008) Physiology , vol.23 , pp. 248-262
    • Yen, W.L.1    Klionsky, D.J.2
  • 185
    • 33749265862 scopus 로고    scopus 로고
    • Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1
    • Yoon Y.S., Yoon D.S., Lim I.K., Yoon S.H., Chung H.Y., Rojo M., Malka F., Jou M.J., Martinou J.C., Yoon G. Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J. Cell. Physiol. 2006, 209:468-480.
    • (2006) J. Cell. Physiol. , vol.209 , pp. 468-480
    • Yoon, Y.S.1    Yoon, D.S.2    Lim, I.K.3    Yoon, S.H.4    Chung, H.Y.5    Rojo, M.6    Malka, F.7    Jou, M.J.8    Martinou, J.C.9    Yoon, G.10
  • 186
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • Zhang R., Chen W., Adams P.D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 2007, 27:2343-2358.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 188
    • 77958552389 scopus 로고    scopus 로고
    • New biomarkers probing the depth of cell senescence assessed by laser scanning cytometry
    • Zhao H., Halicka H.D., Jorgensen E., Traganos F., Darzynkiewicz Z. New biomarkers probing the depth of cell senescence assessed by laser scanning cytometry. Cytometry A 2010, 77A:999-1007.
    • (2010) Cytometry A , vol.77 A , pp. 999-1007
    • Zhao, H.1    Halicka, H.D.2    Jorgensen, E.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 189
    • 0038368985 scopus 로고    scopus 로고
    • Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide
    • Zhao H., Kalivendi S., Zhang H., Joseph J., Nithipatikom K., Vasquez-Vivar J., Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 2003, 34:1359-1368.
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 1359-1368
    • Zhao, H.1    Kalivendi, S.2    Zhang, H.3    Joseph, J.4    Nithipatikom, K.5    Vasquez-Vivar, J.6    Kalyanaraman, B.7
  • 190
    • 0028108976 scopus 로고
    • Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescein
    • Zhu H., Bannenberg G.L., Moldeus P., Shertzer H.G. Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescein. Arch. Toxicol. 1994, 68:582-587.
    • (1994) Arch. Toxicol. , vol.68 , pp. 582-587
    • Zhu, H.1    Bannenberg, G.L.2    Moldeus, P.3    Shertzer, H.G.4
  • 191
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu J., Woods D., McMahon M., Bishop J.M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998, 12:2997-3007.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4


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