Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy

Toxicology Mechanisms and Methods

Volumn 22, Issue 7, 2012, Pages 512-519

  Cheng, Juan ^a   Wei, Hu Lai ^a   Chen, Jing ^a   Xie, Bei ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Acute myelogenous leukemia; Arsenic trioxide; Autophagy

Indexed keywords

ARSENIC TRIOXIDE; BECLIN 1; DANSYLCADAVERINE; FLUORESCENT DYE; MESSENGER RNA; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL INCLUSION; CELL ORGANELLE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LC3 GENE; LEUKEMIA CELL; PHAGOCYTE; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; AUTOPHAGY; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; K562 CELLS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, PHASE-CONTRAST; MICROTUBULE-ASSOCIATED PROTEINS; OXIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; VACUOLES;

EID: 84865324715     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2012.686534     Document Type: Article

References (36)

1. Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, Liu MM, He KL, Niu C, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Kitamura K, Miller W, Waxman S, Wang ZY, de Te H, Chen SJ, Chen Z. 1997. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual efects on APL cells. Blood 89:3345-3353. (Pubitemid 27229821)
2. Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY. 1997. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efcacy and pharmacokinetics in relapsed patients. Blood 89:3354-3360.
3. Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ, Corso D, DeBlasio A, Gabrilove J, Scheinberg DA, Pandolf PP, Warrell RP Jr. 1998. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 339:1341-1348. (Pubitemid 28509343)
4. Akao Y, Mizoguchi H, Kojima S, Naoe T, Ohishi N, Yagi K. 1998. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein. Br J Haematol 102:1055-1060. (Pubitemid 28410539)
5. Hu XM, Hirano T, Oka K. 2003. Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol 51:119-126. (Pubitemid 36259471)
6. Li YM, Broome JD. 1999. Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells. Cancer Res 59:776-780. (Pubitemid 29086725)
7. Lu M, Levin J, Sulpice E, Sequeira-Le Grand A, Alemany M, Caen JP, Han ZC. 1999. Efect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Exp Hematol 27:845-852. (Pubitemid 29231022)
8. Rousselot P, Labaume S, Marolleau JP, Larghero J, Noguera MH, Brouet JC, Fermand JP. 1999. Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer Res 59:1041-1048. (Pubitemid 29135964)
9. Gartenhaus RB, Prachand SN, Paniaqua M, Li Y, Gordon LI. 2002. Arsenic trioxide cytotoxicity in steroid and chemotherapy-resistant myeloma cell lines: enhancement of apoptosis by manipulation of cellular redox state. Clin Cancer Res 8:566-572. (Pubitemid 34193978)
10. Anthony J. Murgo. Clinical Trials of Arsenic Trioxide in Hematologic and Solid Tumors: Overview of the National Cancer Institute Cooperative Research and Development Studies. Oncologist 2001;6:22-28. (Pubitemid 32405846)
11. Jing Chen, Yanyun Ma, Bei Wang, Juan Yi, Linjing Li. 2009. Te apoptosis of leukemia K562 cells induced by arsenic trioxide and the participation of mitochondria and endoplasmic reticulum. Zhonghua Xue Ye Xue Za Zhi 30:477-479.
12. Wang DH, Wei HL, Zhao HS, Hao CY, Min ZH, Liu JM. 2005. Arsenic trioxide overcomes apoptosis inhibition in K562/ADM cells by regulating vital components in apoptotic pathway. Pharmacol Res 52:376-385.
13. Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477. (Pubitemid 38456176)
14. Gozuacik D, Kimchi A. 2004. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23:2891-2906. (Pubitemid 38638851)
15. Cheng Y, Qiu F, Tashiro S, Onodera S, Ikejima T. 2008. ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and auto-phagic L929 cell death. Biochem Biophys Res Commun 376:483-488.
16. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. 2005. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 24:980-991. (Pubitemid 40313875)
17. Qian W, Liu J, Jin J, Ni W, Xu W. 2007. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res 31:329-339. (Pubitemid 46073178)
18. Munafó DB, Colombo MI. 2001. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci 114:3619-3629. (Pubitemid 33041044)
19. Zhang JQ, Li YM, Liu T, He WT, Chen YT, Chen XH, Li X, Zhou WC, Yi J F, Ren ZJ et al. 2010. Antitumor efect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy. World J Gastroenterol 16:4281-4290.
20. Mizushima N. 2004. Methods for monitoring autophagy. Int J Biochem Cell Biol 36:2491-2502. (Pubitemid 39119761)
21. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. 1999. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402:672-676. (Pubitemid 129516338)
22. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing [J]. EMBO J 19:5720-5728.
23. Yang C, Kaushal V, Shah SV, Kaushal GP. 2008. Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294:777-787.
24. Morselli E, Galluzzi L, Kepp O, Vicencio JM, Criollo A, Maiuri MC, Kroemer G. 2009. Anti-and pro-tumor functions of autophagy. Biochim Biophys Acta 1793:1524-1532.
25. Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao L, Sun K, Shen F, Wu M, Wei L. 2009. Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy 5:1131-1144.
26. Bellodi C, Lidonnici MR, Hamilton A, Helgason G V, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B. 2009. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 119:1109-1123.
27. Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B. 1999. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 59:59-65. (Pubitemid 29339873)
28. Liang XH, Yu J, Brown K, Levine B. 2001. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 61:3443-3449. (Pubitemid 32695039)
29. Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. 2008. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4: 659-668.
30. Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. 2008. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 68:1485-1494. (Pubitemid 351346857)
31. Anai S, Goodison S, Shiverick K, Hirao Y, Brown BD, Rosser CJ. 2007. Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts. Mol Cancer Ter 6:101-111. (Pubitemid 46206672)
32. Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. 2001. Beclin- phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2:330-335. (Pubitemid 32401529)
33. Tanida I, Ueno T, Kominami E. 2004. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem 279:47704-47710. (Pubitemid 39540917)
34. Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Tompson CB, Tsujimoto Y. 2004. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6:1221-1228. (Pubitemid 39625121)
35. Qian WB, Liu JQ, Jin J. 2007. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines viaup-regulation of Beclin-1. Leukemia Research 31:329-339. (Pubitemid 46073178)
36. Pattingre S, Levine B. 2006. Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res 66:2885-2888.