Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells

Cancer Chemotherapy and Pharmacology

Volumn 51, Issue 2, 2003, Pages 119-126

  Hu, Xiao Mei ^a,b   Hirano, Toshihiko ^a   Oka, Kitaro ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b XIYUAN HOSPITAL   (China)

Author keywords

Apoptosis; Arsenic trioxide; Daunorubicin resistance; MOLT 4 cell line; P glycoprotein

Indexed keywords

ARSENIC TRIOXIDE; DAUNORUBICIN; GLYCOPROTEIN P; RHODAMINE 123;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL LINE; CELL SURVIVAL; CELL VIABILITY; DOSE RESPONSE; DRUG EFFECT; DRUG RESISTANCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; LEUKEMIA CELL; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TIME;

EID: 0037330968     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-002-0543-2     Document Type: Article

References (39)

1. Akao Y, Yamada H, Nakagawa Y (2000) Arsenic-induced apoptosis in malignant cells in vitro. Leuk Lymphoma 37:53
2. Aslanian AM, Fletcher BS, Kilberg MS (2001) Asparagine synthetase expression alone is sufficient to induce L-asparaginase resistance in MOLT-4 human leukemia cells. Biochem J 357:321
3. Cai X, Jia P, Shi X (1998) In vitro study on arsenic trioxide-induced apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line (MR-2). Zhonghua Xue Ye Xue Za Zhi 19:339
4. Chaudhary PM, Roninson IB (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66:85
5. Chaudhary PM, Mechetner EB, Roninson IB (1992) Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80:2735
6. 3 induces NB4 cell apoptosis with down regulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood 88:1052
7. 3 exerts dose-dependent dual effects on APL cells. Blood 89:3345
8. Dai J, Weinberg RS, Waxman S, Jing YK (1999) Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood 93:268
9. Efferth T, Lohrke H, Volm M (1989) Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors. Anticancer Res 9:1633
10. El-Sabban ME, Nasr R, Dbaibo G, Hermine O, Abboushi N, Quignon F, Ameisen JC, Bex F, de The H, Bazarbachi A (2000) Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-kappa B activation. Blood 96:2849
11. Flescher E, Rotem R, Kwon P, Azare J, Jaspers I, Cohen D (2000) Aspirin enhances multidrug resistance gene 1 expression in human MOLT-4 T lymphoma cells. Anticancer Res 20:4441
12. Fojo A, Akiyama S, Gottesman MM, Pastan I (1985) Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res 45:3002
13. Grad JM, Bahlis NJ, Reis I, Oshiro MM, Dalton WS, Boise LH (2001) Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood 98:805
14. Hirano T, Gotoh M, Oka K (1994) Natural flavonoids and lignans as candidates for non-cytotoxic antiproliferative anti-leukemia. Life Sci 55:1061
15. Hirano T, Abe K, Gotoh M, Oka K (1995) Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72:1380
16. Hirsch-Ernst KI, Ziemann C, Rustenbeck I, Kahl GF (2001) Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures. Toxicology 167:47
17. Hu XM, Ma L, Hu NP, Wang ZF, Yang L, Li L, Wang ZX, Wang HZ, Wang N, Liu C, Liu F, Yang JM, Ma R (1999) Ai-Lin I treated 62 cases of acute promyelocytic leukemia (in Chinese). Chin J Integrat Chin West Med 19:473
18. Hu XM, Ma L, Hu NP, Wang ZF, Yang L, Li L, Wang ZX, Wang HZ, Wang N, Liu C, Liu F, Yang JM, Ma R (1999) Ai-Lin I treated 62 cases of acute promyelocytic leukemia (in Japanese). Chin J Integrat Chin West Med 4:23
19. Hu XM, Deng CS, Ma R (2000) Present status of study on reversion of anti-leukemic multidrug resistance (in Chinese). Chin J Integrat Chin West Med 20:715
20. Hu XM, Deng CS, Ma R (2001) Present status of study on reversion of anti-leukemic multidrug resistance (in Japanese). Chin J Integrat Chin West Med 12:71
21. Hu XM, Deng CS, Ma R (2001) Present status of study on reversion of anti-leukemic multidrug resistance (in English). Chin J Integrat Chin West Med 7:307
22. Ishitsuka K, Hanada S, Suzuki S, Utsunomiya A, Chyuman Y, Takeuchi S, Takeshita T, Shimotakahara S, Uozumi K, Makino T, Arima T (1998) Arsenic trioxide inhibits growth of human T-cell leukaemia virus type I infected T-cell lines more effectively than retinoic acids. Br J Haematol 103:721
23. Liu ZL, Onda k, Tanaka S, Toma T, Hirano T, Oka K (2002) Induction of multidrug resistance in MOLT-4 cells by anti-cancer agents is closely related to increased expression of functional P-glycoprotein and MDR1 mRNA. Cancer Chemother Pharmacol 49:391
24. Ludescher C, Gattringer C, Drach J, Hofmann J, Grunicke H (1991) Rapid functional assay for the detection of multidrug-resistant cells using the fluorescent dye rhodamine 123. Blood 78:1385
25. Ludescher C, Thalar J, Drach D, Drach J, Spitaler M, Gattringer C, Huber H, Homann J (1992) Detection of activity of p-glycoprotein in human tumor samples using rhodamine 123. Br J Haematol 82:161
26. Neyfakh AA (1988) Use of fluorescent dyes as molecular probes for the study of multidrug resistance. Exp Cell Res 174:168
27. Niu BC, Yan H, Yu T, Sun H-P, Liu J-X, Li X-S, Wu W, Zhang F-Q, Chen Y, Zhou L, Li J-M, Zeng X-T, Yang R-RO, Yuan M-M, Ren M-Y, Gu F-Y, Cao Q, Gu B-W, Su X-Y, Chen G-Q, Xiong S-M, Zhang T-d, Waxman S, Wang Z-Y, Chen Z, Hu J, Shen Z-X, Chen S-J (1999) Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood 94:3315
28. Ochi T, Kaise T, Oya-Ohta Y (1994) Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells. Experientia 50:115
29. Perkins C, Kim CN, Fang G, Bhalla KN (2000) Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood 95:1014
30. Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF (2001) Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO J 20:5615
31. 3 induces apoptosis of the human B lymphoma cell line MBC-1. J Biol Regul Homeost Agents 14:116
32. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354
33. Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, Stone RM, Kalaycio M, Scheinberg DA, Steinherz P, Sievers EL, Coutre S, Dahlberg S, Ellison R, Warrell RP Jr (2001) United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol 19:3852
34. Sun HD, Ma L, Hu XC, Zhang TD (1992) Ai-Lin I treated 32 cases of acute promyelocytic leukemia. Chin J Integrat Chin West Med 12:170
35. Wang ZG, Rivi R, Delva L, Konig A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP Jr, Pandolfi PP (1998) Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RAR alpha independent manner. Blood 92:1497
36. Waxman S, Anderson KC (2001) History of the development of arsenic derivatives in cancer therapy. Oncologist [Suppl] 2:3
37. Zhang P, Wang SY, Hu LH, Shi FD, Qiu FQ, Hong GJ, Han XY, Yang HF, Sun YZ, Liu YP, Zhao J, Jin ZJ (1996) Arsenic trioxide treated 72 cases of acute promyelocytic leukemia. Chin J Hematol 2:58
38. Zhang W, Ohnishi K, Shigeno K, Fujisawa S, Naito K, Nakamura S, Takeshita K, Takeshita A, Ohno R (1998) The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms. Leukemia 12:1383
39. Zhang Y, Nie L (2001) Studies of apoptosis of malignant lymphoma cells induced by arsenic trioxide. Cell Biol Int 25:1003