Biomaterial strategies for alleviation of myocardial infarction

Journal of the Royal Society Interface

Volumn 9, Issue 66, 2012, Pages 1-19

  Venugopal, Jayarama Reddy ^a   Prabhakaran, Molamma P ^a   Mukherjee, Shayanti ^a   Ravichandran, Rajeswari ^a   Dan, Kai ^a   Ramakrishna, Seeram ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biomaterials; Cardiomyocytes; Hydrogels; Injectables; Mesenchymal stem cells; Myocardial infarction

Indexed keywords

BIOMATERIALS; BIOMOLECULES; BIOPOLYMERS; CARDIOLOGY; CELL CULTURE; COLLAGEN; DISEASES; HYDROGELS; MECHANICAL STABILITY; MUSCLE; REPAIR; SAFETY ENGINEERING; STEM CELLS; TISSUE ENGINEERING;

CARDIAC MUSCLES; CARDIAC TISSUE ENGINEERING; CARDIAC TISSUES; CARDIOMYOCYTES; CAUSES OF DEATH; CORONARY ARTERY DISEASE; FIBROBLAST PROLIFERATION; FUNCTIONAL PROPERTIES; GLOBAL EPIDEMIC; HEART FAILURE; HEART MUSCLES; INDUSTRIALIZED COUNTRIES; INJECTABLE BIOMATERIALS; INJECTABLES; INTRINSIC MECHANISMS; LEFT VENTRICLES; LEFT VENTRICULAR FUNCTION; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELLS; MINIMALLY INVASIVE; MYOCARDIAL INFARCTION; NATIVE COLLAGEN; PLURIPOTENT STEM CELLS; SELF-ASSEMBLING PEPTIDES; WORLD HEALTH ORGANIZATION;

HEART;

1,3 TRIMETHYLENE CARBONATE; ALGINIC ACID; BIOMATERIAL; BIOPOLYMER; CARBONIC ACID DERIVATIVE; CHITOSAN; COLLAGEN; COPOLYMER; FIBRIN; FIBRONECTIN; GLYCOSAMINOGLYCAN; LAMININ; MARLEX; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; POLITEF; POLY(1,8 OCTANEDIOL CO CITRIC ACID); POLY(3 HYDROXYBUTYRIC ACID); POLY(DEXTRO,LEVO LACTIDE); POLY(GLYCEROL SEBACATE); POLY(LACTIC ACID) CO POLY(EPSILON CAPROLACTONE); POLY(PARA DIOXANONE); POLYESTER; POLYGLYCOLIC ACID; POLYLACTIC ACID; PROTEOGLYCAN; TROPONIN T; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ADIPOSE DERIVED STEM CELL; BIOREACTOR; BONE MARROW CELL; CAUSE OF DEATH; CELL FUNCTION; CELL PROLIFERATION; ELASTIC FIBER; EXTRACELLULAR MATRIX; FIBROBLAST; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART TRANSPLANTATION; HUMAN; HYDROGEL; MESENCHYMAL STEM CELL; MYOBLAST; NONHUMAN; REVIEW; TISSUE ENGINEERING; TRANSLUMINAL CORONARY ANGIOPLASTY; UMBILICAL CORD BLOOD;

EID: 84255198664     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2011.0301     Document Type: Review

References (169)

1. Joggerst, S. J. & Hatzopoulos, A. K. 2009 Stem cell therapy for cardiac repair: benefits and barriers. Expert Rev. Mol. Med. 11, e20. (doi:10.1017/S1462399409001124)
2. Baig, M. K., Mahon, N., McKenna, W. J., Cafori, A. L., Bonow, R. O., Francis, G. S. & Gheorghiade, M. 1999 The pathophysiology of advanced heart failure. Heart Lung 28, 87-101. (doi:10.1053/hl.1999.v28.a97762)
3. Chachques, J. C. 2011 Development of bioartificial myocardium using stem cells and nanobiotechnology templates. Cardiol. Res. Pract. 2011, 1-7. (doi:10.4061/2011/806795)
4. Takahashi, H., Yokota, T., Uchimura, E., Miyagawa, S., Ota, T. & Torikai, K. 2009 Newly developed tissue-engineered material for reconstruction of vascular wall without cell seeding. Ann. Thorac. Surg. 88, 1269-1276. (doi:10.1016/j.athoracsur.2009.04.087)
5. Steffens, G. C., Yao, C., Prevel, P., Schenck, P. & Noah, E. M. 2004 Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor. Tissue Eng. 10, 1502-1509.
6. Dvir, T., Kedem, A., Ruvinov, E., Levy, O., Freeman, I. & Landa, N. 2009 Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proc. Natl Acad. Sci. USA 106, 14 990-14 995. (doi:10.1073/pnas. 0812242106)
7. Miyagi, Y., Chiu, L. Y., Cimini, M., Weisel, R. D., Radisic, M. & Li, R. K. 2011 Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair. Biomaterials 32, 1280-1290. (doi:10.1016/j.biomaterials.2010. 10.007)
8. Gojo, S., Gojo, N., Takeda, Y., Hata, J. & Umezawa, A. 2003 In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells. Exp. Cell Res. 288, 51-59. (doi:10.1016/S0014-4827(03)00132-0)
9. Perin, E. C. & Silva, G. V. 2004 Stem cell therapy for cardiac diseases. Curr. Opin. Hematol. 11, 399-403. (doi:10.1097/01.moh.0000143359. 77689.aa)
10. Muller-Ehmsen, J., Kedes, L. H. & Kloner, R. A. 2002 Cellular cardiomyoplasty: a novel approach to treat heart disease. Congest. Heart Fail. 8, 220-227. (doi:10.1111/j.1527-5299.2002.00292.x)
11. Radisic, M., Park, H., Gerecht, S., Langer, R. & Vunjak-Novakovic, G. 2007 Biomimetic approach to cardiac tissue engineering. Phil. Trans. R. Soc. B 362, 1357-1368. (doi:10.1098/rstb.2007.2121)
12. Severs, N. J. 2000 The cardiac muscle cell. Bioessays 22, 188-199. (doi:10.1002/(SICI)1521-1878(200002)22:2〈188::AID-BIES10〉3.0.CO;2-T)
13. Wall, S. T., Walke, J. C. & Guccione, J. M. 2006 Theoretical impact of material into the myocardium - a finite element model simulation. Circulation 114, 2627-2635. (doi:10.1161/CIRCULATIONAHA.106.657270)
14. Nagueh, S. F., Shah, G., Wu, Y. & Lahmers, S. 2004 Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 110, 155-162. (doi:10.1161/01.CIR. 0000135591.37759.AF)
15. Omen, J. H. 1988 Stress and strain as regulators of myocardial growth. Prog. Biophys. Mol. Biol. 69, 559-572. (doi:10.1016/S0079-6107(98)00025-X)
16. Menasche, P., Hageg, A. A., Scorsin, M. & Duboc, D. 2001 Myoblast transplantation for heart failure. Lancet 357, 279-280. (doi:10.1016/S0140- 6736(00)03617-5)
17. Flachskampf, F. A., Chandra, S., Gaddipatti, A. & Ameling, W. 2000 Analysis of shape and motion of the mitral annulus in subjects with and without cardiomyopathy by echocardiographic 3-dimensional reconstruction. J. Am. Soc. Echocardiogr. 13, 277-287. (doi:10.1067/mje.2000.103878)
18. Fujimoto, K. L., Tobita, K., Merryman, W. D., Guan, J. J. & Stolz, D. B. 2007 An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction. J. Am. Coll. Cardiol. 49, 2292-2300. (doi:10.1016/j.jacc.2007.02. 050)
19. Radisic, M., Marsano, A., Maidhof, R., Wang, Y. & Vunjak-Novakovic, G. 2008 Cardiac tissue engineering using bioreactor systems. Nat. Protocols 3, 719-738. (doi:10.1038/nprot.2008.40)
20. Wei, H.-J., Chen, C.-H. & Sung, W. 2008 Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair. Biomaterials 29, 3547-3556. (doi:10.1016/j.biomaterials.2008.05.009)
21. Park, H., Radisic, M., Lim, J. O., Chang, B. H. & Vunjak-Novakovic, G. 2005 A novel composite scaffold for cardiac tissue engineering. In Vitro Cell Dev. Biol Anim. 41, 188-196. (doi:10.1290/0411071.1)
22. Chachques, J. C., Trainini, J. C., Lago, N., Masoli, O. H., Barisani, J. L. & Carpentier, A. 2007 Myocardial assistance by grafting a new bioartificial upgraded myocardium (MAGNUM clinical trial): one year follow-up. Cell Transplant. 16, 927-934. (doi:10.3727/096368907783338217)
23. Mukherjee, S., Venugopal, J., Rajeswari, R., Ramakrishna, S. & Raghunath, M. 2011 Evaluation of the biocompatibility of PLACL/collagen nanostructured matrices with cardiomyocytes as a model for the regeneration of infarcted myocardium. Adv. Funct. Mater. 21, 2291-2300. (doi:10.1002/adfm. 201002434)
24. Hein, S. & Schaper, J. 2001 The extracellular matrix in normal and diseased myocardium. J. Nucl. Cardiol. 8, 188-196. (doi:10.1067/mnc.2001.113331)
25. Jane-Lise, S., Corda, S., Chassagne, C. & Rappaport, L. 2000 The extracellular matrix and the cytoskeleton in heart hypertrophy and failure. Heart Fail. Rev. 5, 239-250. (doi:10.1023/A:1009857403356)
26. Chapman, D., Weber, K. T. & Eghbali, M. 1990 Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Circ. Res. 67, 787-794.
27. Kitamura, M., Shimizu, M., Ino, H., Okeie, K. & Nakanishi, I. 2001 Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: the significance of types III and VI collagens. Clin. Cardiol. 24, 325-329. (doi:10.1002/clc.4960240413)
28. Iruela-Arispe, M. L. & Sage, E. H. 1991 Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Dev. Biol. 144, 107-118. (doi:10.1016/0012-1606(91)90483-J)
29. Marijianowski, M. M., Teeling, P., Mann, J. & Becker, A. E. 1995 Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: a quantitative assessment. J. Am. Coll. Cardiol. 25, 1263-1272. (doi:10.1016/0735-1097(94)00557-7)
30. Graham, H. K., Horn, M. & Trafford, A. W. 2008 Extracellular matrix profile in the progression to heart failure. Acta Physiol. 194, 3-21. (doi:10.1111/j.1748-1716.2008.01881.x)
31. Herpel, E., Pritsch, M., Koch, A., Dengler, T. J. & Schnabel, P. A. 2006 Interstitial fibrosis in the heart. Differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischemic and valvular cardiomyopathy. Histopathology 48, 736-747. (doi:10.1111/j.1365-2559. 2006.02398.x)
32. Weber, K. T., Janiciki, J. S., Shroff, S. G., Pick, R. & Bashey, R. I. 1988 Collagen remodeling of the pressure overloaded, hypertrophied nonhuman primate myocardium. Circ. Res. 62, 757-765.
33. Leor, J. & Cohen, S. 2004 Myocardial tissue engineering: crating a muscle patch for wounded heart. Ann. NY Acad. Sci. 1015, 312-319. (doi:10.1196/annals.1302.026)
34. Chachques, J. C., Trainini, J. C., Lago, N., Morichetti, M. C., Schussler, O. & Carpentier, A. 2008 Myocardial assistance by grafting a new bioartificial upgraded myocardium (MAGNUM Trial): clinical fesibility study. Ann. Throac. Surg. 85, 901-908. (doi:10.1016/j.athoracsur.2007.10.052)
35. Garlotta, D. 2001 A literature review of poly(lactic acid). J. Polym. Environ. 9, 63-84. (doi:10.1023/A:1020200822435)
36. Webb, A. R., Yang, J. & Ameer, G. A. 2004 Biodegradable polyester elastomers in tissue engineering. Expert Opin. Biol. Ther. 4, 801-812. (doi:10.1517/14712598.4.6.801)
37. Ramsay, B. A., Langlade, V., Carreau, P. J. & Ramsay, J. A. 1993 Biodegradability and mechanical-properties of poly-(beta-hydroxybutyrate-co- betahydroxyvalerate) starch blends. Appl. Environ. Microbiol. 59, 1242-1246.
38. Pezzin, A. P. T., van Ekenstein, G., Zavaglia, C. A. C., ten Brinke, G. & Deuk, E. A. R. 2003 Poly(para-dioxanone) and poly(L-lactic acid) blends: thermal, mechanical, and morphological properties. J. Appl. Polym. Sci. 88, 2744-2755. (doi:10.1002/app.11984)
39. Yang, J., Webb, A. R. & Ameer, G. A. 2004 Novel citric acid-based biodegradable elastomers for tissue engineering. Adv. Mater. 16, 511-516. (doi:10.1002/adma.200306264)
40. Gao, J., Crapo, P. M. & Wang, Y. D. 2006 Macroporous elastomeric scaffolds with extensive micropores for soft tissue engineering. Tissue Eng. 12, 917-925. (doi:10.1089/ten.2006.12.917)
41. Wang, Y. D., Ameer, G. A., Sheppard, B. J. & Langer, R. 2002 A tough biodegradable elastomer. Nat. Biotechnol. 20, 602-606. (doi:10.1038/nbt0602-602)
42. Misof, K., Landis, W. J., Klaushofer, K. & Fratzl, P. 1997 Collagen from the osteogenesis imperfecta mouse model (OIM) shows reduced resistance against tensile stress. J. Clin. Invest. 100, 40-45. (doi:10.1172/JCI119519)
43. Kumudine, C. & Premachandra, J. K. 1999 Polymer data handbook, pp. 70-77. Oxford, UK: Oxford Press.
44. Roeder, B. A., Kokini, K., Sturgis, J. E., Robinson, J. P. & Voytik-Harbin, S. L. 2002 Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure. J. Biomech. Eng. Trans. ASME 124, 214-222. (doi:10.1115/1.1449904)
45. Bing, O. H. L., Matsushita, S., Fanburg, B. L. & Levine, H. J. 1971 Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circ. Res. 28, 234-245.
46. Yin, F. C., Spurgeon, H. A., Weisfeldt, M. L. & Lakatta, E. G. 1980 Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding. Circ. Res. 46, 292-300.
47. Takaoka, H., Esposito, G., Mao, L., Suga, H. & Rockman, H. A. 2002 Heart size independent analysis of myocardial function in murine pressure overloads hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 282, H2190-H2197.
48. Nakano, K., Sugawara, M., Ishihara, K., Kanazawa, S., Corin, W. & Denslow, S. 1990 Myocardial stiffness derived from end-systolic wall stress and logarithm of reciprocal of wall thickness. Contractility index independent of ventricular size. Circulation 82, 1352-1361. (doi:10.1161/01.CIR.82.4.1352)
49. Watanabe, S., Shite, J., Takaoka, H., Shinke, T., Imuro, Y. & Ozawa, T. 2006 Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure. Eur. Heart J. 27, 832-838. (doi:10.1093/eurheartj/ehi772)
50. Chen, C. H., Wei, H. J., Lin, W. W., Chiu, I., Hwang, S. M., Lee, W. Y., Chang, Y. & Sung, H. W. 2008 Porous tissue grafts sandwiched with multilayered mesenchymal stromal cell sheets induce tissue regeneration for cardiac repair. Cardiovasc. Res. 80, 88-95. (doi:10.1093/cvr/cvn149)
51. Chen, Q. Z., Bismarck, A., Hansen, U., Junaid, S., Tran, M. Q., Harding, S. E. & Boccaccini, A. R. 2008 Characterization of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials 29, 47-57. (doi:10.1016/j.biomaterials.2007.09. 010)
52. Chen, Q. Z., Harding, S. E., Ali, N. N., Lyon, A. R. & Boccaccini, A. R. 2008 Biomaterials in cardiac tissue engineering: ten years of research survey. Mater. Sci. Eng. R. 59, 1-37. (doi:10.1016/j.mser.2007.08.001)
53. Shachar, M. & Cohen, S. 2003 Cardiac tissue engineering, ex-vivo: design principles in biomaterials and bioreactors. Heart Fail. Rev. 8, 271-276. (doi:10.1023/A:1024729919743)
54. Radisic, M. & Vunjak-Novakovic, G. 2005 Cardiac tissue engineering. J. Serbian Chem. Soc. 70, 541-556. (doi:10.2298/JSC0503541R)
55. Davis, M. E., Motion, J. P., Narmoneva, D. A., Takahashi, T., Hakuno, D., Zhang, S. & Lee, R. T. 2005 Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation 111, 442-450. (doi:10.1161/01.CIR.0000153847.47301.80)
56. Rezwan, K., Chen, Q. Z., Blaker, J. J. & Boccaccini, A. R. 2006 Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27, 3413-3431. (doi:10.1016/j. biomaterials.2006.01.039)
57. Zimmermann, W.-H., Melnychenko, I., Wasmeier, G., Didie, M. & Eschenhagen, T. 2006 Engineered heart tissue grafts improve systolic and diastolic function in infracted rat hearts. Nat. Med. 12, 452-458. (doi:10.1038/nm1394)
58. Zimmermann, W.-H., Didie, M., Doke, S., Melnychenko, I., Naito, H., Rogge, C., Tiburcy, M. & Eschenhagen, T. 2006 Heart muscle engineering: an update on cardiac muscle replacement therapy. Cardiovasc. Res. 71, 419-429. (doi:10.1016/j.cardiores.2006.03.023)
59. Ott, H. C., Matthiesen, T. S., Goh, S. K., Black, L. D., Kren, S. M., Netoff, T. I. & Taylor, D. A. 2008 Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat. Med. 14, 213-221. (doi:10.1038/nm1684)
60. Engelmayr Jr, G. C., Cheng, M., Bettinger, C. J., Borenstein, J. T., Langer, R. & Freed, L. E. 2008 Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat. Mater. 7, 1003-1010. (doi:10.1038/nmat2316)
61. Ozawa, T., Mickle, D. A., Weisel, R. D., Koyama, N., Wong, H., Ozawa, S. & Li, R. K. 2003 Histological changes of non-biodegradable and biodegradable biomaterials used to repair right ventricular heart defects in rats. J. Thorac. Cardiovasc. Surg. 126, 2113-2114. (doi:10.1016/j.jtcvs.2003.03.002)
62. Jin, J., Jeong, S. I., Shin, Y. M., Lim, K. S. & Kim, K. S. 2009 Transplantation of mesenchymal stem cells with a poly(lactide-co-e-caprolactone) scaffold improves cardiac function in a rat myocardial infarction model. Euro. J. Heart Fail. 11, 147-153. (doi:10.1093/eurjhf/hfn017)
63. Zmora, S., Glicklis, R. & Cohen, S. 2002 Tailoring the pore architecture in 3D alginate scaffolds by controlling the freezing regime during fabrication. Biomaterials 23, 4087-4094. (doi:10.1016/S0142-9612(02)00146-1)
64. Eschenhagen, T. & Zimmermann, W. H. 2005 Engineering myocardial tissue. Circ. Res. 97, 1220-1231. (doi:10.1161/01.RES.0000196562.73231.7d)
65. Li, R. K., Jia, Z. Q., Weisel, R. D., Mickle, D. A. G., Choi, A. & Yau, T. M. 1999 Survival and function of bioengineered cardiac grafts. Circulation 100, II63-II169.
66. Xiang, Z., Liao, R. L., Kelly, M. S. & Spector, M. 2006 Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 12, 2467-2478. (doi:10.1089/ten.2006.12. 2467)
67. Christman, K. L., Fang, O., Yee, M. S., Johnson, K. R., Sievers, R. E. & Lee, R. J. 2005 Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials 26, 1139-1144. (doi:10.1016/j.biomaterials.2004.04.025)
68. Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Hubib, I. H. & Levenberg, S. 2007 Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ. Res. 100, 263-272. (doi:10.1161/01.RES. 0000257776.05673.ff)
69. Shin, M., Ishii, O., Sueda, T. & Vacanti, J. P. 2004 Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials 25, 3717-3723. (doi:10.1016/j.biomaterials.2003.10.055)
70. Freed, L. E. & Vunjak-Novakovic, G. 1997 Microgravity tissue engineering. In Vitro Cell Dev. Biol. Anim. 33, 381-385. (doi:10.1007/s11626- 997-0009-2)
71. Alperin, C., Zandstra, P. W. & Woodhouse, K. A. 2005 Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications. Biomaterials 26, 7377-7386. (doi:10.1016/j.biomaterials.2005.05.064)
72. Marsano, A., Maidhof, R., Tandon, N., Gao, J., Wang, Y. & Vunjak-Novakovic, G. 2008 Engineering of functional contractile cardiac tissues cultured in a perfusion system. Conf. Proc. IEEE. Eng. Med. Biol. Soc. 2008, 3590-3593.
73. Hidalgo-Bastida, L. A., Barry, J. J., Hall, I. P., Claycomb, W. C. & Shakesheff, K. M. 2007 Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering. Acta Biomater. 3, 457-462. (doi:10.1016/j.actbio.2006.12.006)
74. Zhang, J. C., Wojta, J. & Binder, B. R. 1995 Growth and fibrinolytic parameters of human umbilical vein endothelial cells seeded onto cardiovascular grafts. J. Thorac. Cardiovasc. Surg. 109, 1059-1065. (doi:10.1016/S0022-5223(95) 70188-5)
75. Bowen, F. W., Jones, S. C., Narula, N., Sutton, M., Plappert, T. & Edmunds, L. H. 2001 Restraining acute infarct expansion decreases collagenase activity in border zone myocardium. Ann. Thorac. Surg. 72, 1950-1956. (doi:10.1016/S0003-4975(01)03282-9)
76. Lipinski, M. J., Biondi-Zoccai, G. G., Strauer, B. E. & Vetrovec, G. W. 2007 Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and metaanalysis of controlled clinical trials. J. Am. Coll. Cardiol. 50, 1761-1767. (doi:10.1016/j.jacc.2007.07.041)
77. Strauer, B. E., Brehm, M., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kogler, G. & Wernet, P. 2002 Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106, 1913-1918. (doi:10. 1161/01.CIR.0000034046.87607.1C)
78. Christman, K. L., Vardanian, A. J., Fang, Q., Fok, H. H. & Lee, R. J. 2004 Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion and induces neovasculature formation in ischemic myocardium. J. Am. Coll. Cardiol. 44, 654-660. (doi:10.1016/j.jacc.2004.04.040)
79. Christman, K. L., Fok, H. H., Sievers, R. E., Fang, Q. H. & Lee, R. J. 2004 Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Eng. 10, 403-409. (doi:10.1089/107632704323061762)
80. Walsh, R. G. 2005 Design and features of the Acorn CorCap cardiac support device: the concept of passive mechanical diastolic support. Heart Fail. Rev. 10, 101-107. (doi:10.1007/s10741-005-4637-x)
81. Kofidis, T., Lebl, D. R., Martinez, E. C., Hoyt, G., Tanaka, M. & Robbins, R. C. 2005 Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation 112, I173-I177.
82. Zimmermann, W.-H. & Eschenhagen, T. 2003 Cardiac tissue engineering for replacement therapy. Heart Fail. Rev. 8, 259-269. (doi:10.1023/A: 1024725818835)
83. Leor, J., Guetta, E., Chouraqui, P., Guetta, V. & Nagler, A. 2005 Human umbilical cord blood cells: a new alternative for myocardial repair? Cytotherapy 7, 251-257. (doi:10.1080/14653240510027163)
84. Taylor, D. A., Atkins, B. Z. & Hungspreugs, P. 1998 Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. 4, 929-933. (doi:10.1038/nm0898-929)
85. Perin, E. C., Dohmann, H. F. & Borojevic, R. 2003 Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107, 2294-2302. (doi:10.1161/01.CIR.0000070596.30552.8B)
86. Itescu, S., Kocher, A. A. & Schuster, M. D. 2002 Myocardial neovascularization by adult bone marrow-derived angioblasts: strategies for improvement of cardiomyocyte function. Ann. Hematol. 81(Suppl. 2), S21-S25.
87. Orlic, D., Kajstura, J. & Chimenti, S. 2001 Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705. (doi:10.1038/35070587)
88. Stamm, C., Westphal, B., Kleine, H. D. & Kittner, C. 2003 Autologous bone marrow stem-cell transplantation for myocardial regeneration. Lancet 361, 45-46. (doi:10.1016/S0140-6736(03)12110-1)
89. Davani, S., Marandin, A., Mersin, N. & Kantelip, J. P. 2003 Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density and improve heart function in a rat cellular cardiomyoplasty model. Circulation 108(Suppl. 1), II253-II258.
90. Matsubayashi, K., Fedak, P. W. & Mickle, D. A. 2003 Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts. Circulation 108(Suppl. 1), 219-225.
91. Henning, R. M., Abu-Ali, H. & Balis, J. U. 2004 Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction. Cell Transplant. 13, 729-739. (doi:10.3727/000000004783983477)
92. Kellar, R. S., Landeen, L. K. & Shepherd, B. R. 2001 Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue. Circulation 104, 2063-2068. (doi:10.1161/hc4201.097192)
93. Kehat, I., Khimovich, L. & Caspi, O. 2004 Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22, 1282-1289. (doi:10.1038/nbt1014)
94. Beltrami, A. P., Barlucchi, L. & Torella, D. 2003 Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114, 763-776. (doi:10.1016/S0092-8674(03)00687-1)
95. Messina, E., De Angelis, L. & Frati, G. 2004 Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res. 95, 911-921. (doi:10.1161/01.RES.0000147315.71699.51)
96. Oh, H., Bradfute, S. B. & Gallardo, T. D. 2003 Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. USA 100, 12313-12318. (doi:10.1073/pnas. 2132126100)
97. Lanza, R., Moore, M. A. & Wakayama, T. 2004 Regeneration of the infarcted heart with stem cells derived by nuclear transplantation. Circ. Res. 94, 820-827. (doi:10.1161/01.RES.0000120863.53562.DF)
98. Nag, A. C. & Zak, R. 1979 Dissociation of adult mammalian heart into single cell suspension: an ultrastructural study. J. Anat. 129, 541-559.
99. Long, C. S., Henrich, C. J. & Simpson, P. C. 1991 A growth factor for cardiac myocytes is produced by cardiac nonmyocytes. Cell Regul. 2, 1081-1095.
100. MacCarthy, P. A., Grieve, D. J., Li, J.-M., Dunster, C., Kelly, F. J. & Shah, A. M. 2001 Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy. Circulation 104, 2967-2974. (doi:10.1161/hc4901.100382)
101. Beltrami, C. A., Finatom, N., Rocco, M., Feruglio, G. A., Puricelli, C., Olivetti, G. & Anversa, P. 1994 Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89, 151-163.
102. Gepstein, L. 2002 Derivation and potential applications of human embryonic stem cells. Circ. Res. 91, 866-876. (doi:10.1161/01.RES.0000041435. 95082.84)
103. Katritsis, D. G., Sotiropoulou, P. A. & Karvouni, E. 2005 Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc. Interv. 65, 321-329. (doi:10.1002/ccd.20406)
104. Song, H., Song, B. W., Cha, M. J. & Hwang, K. C. 2010 Modification of mesenchymal stem cells of cardiac regeneration. Expert Opin. Biol. Ther. 10, 309-319. (doi:10.1517/14712590903455997)
105. Hare, J. M., Traverse, J. H., Henry, T. D., Dib, N., Schaer, G. L. & Sherman, W. A. 2009 A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J. Am. Coll. Cardiol. 54, 2277-2286. (doi:10.1016/j.jacc.2009.06.055)
106. Chen, S. L., Fang, W. W., Ye, F., Liu, Y. H., Lin, S. & Sun, J. P. 2004 Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. 94, 92-95. (doi:10.1016/j.amjcard.2004.03.034)
107. Miyahara, Y., Nagaya, N., Kataoka, M., Yanagawa, B., Kitamura, S. & Mori, H. 2006 Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat. Med. 12, 459-465. (doi:10.1038/nm1391)
108. Chachques, J. C., Lajos, C. S., Lajos, P., Shafy, A., Alshamry, A. & Carpentier, A. 2005 Cellular cardiomyoplasty for myocardial regeneration. Asian Cardiovasc. Thorac. Ann. 13, 287-296.
109. Kocher, A. A., Schuster, M. D., Szabolcs, M. J., Edwards, N. M. & Itescu, S. 2001 Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 7, 430-436. (doi:10.1038/86498)
110. Tomita, S., Mickle, D. A. & Weisel, R. D. 2002 Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stem cell transplantation. J. Thorac. Cardiovasc. Surg. 123, 1132-1135. (doi:10.1067/mtc.2002.120716)
111. Caspi, O. & Gepstein, L. 2006 Stem cells for myocardial repair. Eur. Heart. J. Suppl. 8(Suppl. E), E43-E54. (doi:10.1093/eurheartj/sul031)
112. Brehm, M. & Strauer, B. E. 2006 Stem cell therapy in post-infarction chronic coronary heart disease. Nat. Clin. Pract. Cardiovasc. Med. 3(Suppl. 1), S101-S104. (doi:10.1038ncpcardio0431)
113. Sekine, H., Shimizu, T., Yamato, M., Kurosawa, H., Kobayashi, E. & Okano, T. 2008 Enhances neovascularization and improves cardiac function of ischemic hearts. Circulation 118, S145-S152. (doi:10.1161/CIRCULATIONAHA.107. 757286)
114. Itabashi, Y., Miyoshi, S., Kawaguchi, H., Yuasa, S., Shimizu, T., Fukuda, K. & Ogawa, S. 2005 A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping. Artif. Organs 29, 95-103. (doi:10.1111/j.1525-1594.2005.29020.x)
115. Masuda, S., Shimizu, T., Yamato, M. & Okano, T. 2008 Cell sheet engineering for heart repair. Adv. Drug. Deliv. Rev. 60, 277-285. (doi:10.1016/j.addr.2007.08.031)
116. Eschenhagen, T., Didie, M. & Zimmermann, H. 2002 3D engineered heart tissue for tissue replacement therapy. Basic Res. Cardiol. 97, I146-I152. (doi:10.1007/s003950200043)
117. Zimmermann, W.-H. & Eschenhagen, T. 2007 Embryonic stem cells for cardiac muscle engineering. Trends Cardiovasc. Med. 17, 134-140. (doi:10.1016/j.tcm.2007.02.007)
118. Leor, J., Amsalem, Y. & Cohen, S. 2005 Cells, scaffolds, and molecules for myocardial tissue engineering. Pharmacol. Therapeut. 105, 151-163. (doi:10.1016/j.pharmthera.2004.10.003)
119. Memon, I. A., Sawa, Y., Fukushima, N., Taketani, S., Aleshin, A. N. & Matsuda, H. 2005 Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J. Thorac. Cardiovasc. Surg. 130, 1333-1341. (doi:10.1016/j.jtcvs.2005.07.023)
120. Farahmand, P., Lai, T. Y., Weisel, R. D., Fazel, S., Menasche, P. & Li, R. K. 2008 Skeletal myoblasts preserve remote matrix architecture and global function when implanted early or late after coronary ligation into infarcted or remote myocardium. Circulation 118(Suppl. 14), S130-S137. (doi:10.1161/ CIRCULATIONAHA.107.757617)
121. Roell, W., Lewalter, T., Sasse, P., Tallini, Y. N., Choi, B. R., Breitbach, M., Kotlikoff, M. I. & Fleischmann, B. K. 2007 Engraftment of connexin-43 expressing cells prevents post-infarct arrhythmia. Nature 450, 819-824. (doi:10.1038/nature06321)
122. Chachques, J. C., Shafy, A., Durate, F., Shen, L. & Carpentier, A. 2002 From dynamic to cellular cardiomyoplasty. J. Card. Surg. 17, 194-200. (doi:10.1111/j.1540-8191.2002.tb01199.x)
123. Shafy, A., Lavergne, T., Latremouille, C., Carpentier, A. & Chachques, J. C. 2009 Association of electrostimulation with cell transplantation in ischemic heart disease. J. Thorac. Cardiovas. Surg. 138, 994-1001. (doi:10.1016/j.jtcvs.2009.02.025)
124. Pagani, F. D., DerSimonian, H. & Zawadzka, A. 2003 Autologous skeletalmyoblast transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J. Am. Coll. Cardiol. 41, 879-888. (doi:10.1016/S0735-1097(03)00081-0)
125. Rajnoch, C., Chachques, J. C., Berrebi, A., Bruneval, P., Benoit, M. O. & Carpetier, A. 2001 Cellular therapy reveres myocardial dysfunction. J. Thorac. Cardiovasc. Surg. 12, 871-878. (doi:10.1067/mtc.2001.112937)
126. Dib, N., Dinsmore, J., Lababidi, Z., White, B., Jaber, W. A., Rizenhour, C. S. & Diethrich, E. 2009 Oneyear follow-up of feasibility and safety of the first U.S., randomized, controlled study using 3-dimensional guided catheter-based delivery of autologous skeletal myoblasts for ischemic cardiomyopathy (CAuSMIC study). JACC Cardiovasc. Interv. 2, 9-16. (doi:10.1016/j.jcin.2008.11.003)
127. Hristov, H., Erl, W. & Weber, P. C. 2003 Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler. Thromb. Vasc. Biol. 23, 1185-1189. (doi:10.1161/01.ATV.0000073832.49290.B5)
128. Murohara, T., Ikeda, H., Duan, J. & Imaizumi, T. 2000 Transplanted cord blood derived endothelial precursor cells augment postnatal neovascularization. J. Clin. Invest. 105, 1527-1536. (doi:10.1172/JCI8296)
129. Vendrame, M., Cassady, J., Newcomb, J. & Willing, A. E. 2004 Infusion of human umbilical cord blood cells in a rat model of stroke dose dependently rescues behavioral deficits and reduces infarct volume. Stroke 35, 2390-2395. (doi:10.1161/01.STR.0000141681.06735.9b)
130. Cortes-Morichetti, M., Frati, G., Schussler, O., Carpentier, A. F. & Chachques, J. C. 2007 Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and regeneration. Tissue Eng. 13, 2681-2687. (doi:10.1089/ten.2006.0447)
131. Fraser, J. K., Wulur, I., Alfonso, Z. & Hedrick, M. K. 2006 Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotech. 24, 150-154. (doi:10.1016/j.tibtech.2006.01.010)
132. Mazo, M., Gavira, J. J., Pelacho, B. & Prosper, F. 2011 Adipose-derived stem cells for myocardial infarction. J. Cardiovas. Trans. Res. 4, 145-153. (doi:10.1007/s12265-010-9246-y)
133. Choi, Y. S., Matsuda, K., Dusting, G. J., Morrison, W. A. & Dilley, R. J. 2010 Engineering cardiac tissue in vivo from human adipose-derived stem cells. Biomaterials 31, 2236-2242. (doi:10.1016/j.biomaterials.2009.11.097)
134. Rigol, M., Solanes, N., Farre, J., Roura, S., Roque, M. & Heras, M. 2010 Effects of adipose tissue-derived stem cell therapy after myocardial infarction: impact of the route of administration. J. Card. Fail. 16, 357-366. (doi:10.1016/j.cardfail.2009.12.006)
135. Okura, H., Matuyama, A., Lee, C. M., Saga, A. & Sawa, Y. 2010 Cardiomyoblast-like cells differentiated from human adipose derived mesenchymal stem cells improve left ventricular dysfunction and survival in rat myocardial infarction model. Tissue Eng. Part A 16, 417-425. (doi:10.1089/ten.tec.2009. 0362)
136. Rubina, K., Kalinina, N., Efimenko, A., Lopatina, T., Melikhova, V. & Tsokolaeva, Z. 2009 Secretion of angiogenic factors, and enhancing vessel maturation. Tissue Eng. Part A 15, 2039-2050. (doi:10.1089/ten.tea.2008.0359)
137. Zachar, V., Duroux, M., Emmersen, J., Rasmussen, J., Pennisi, C. P., Yang, S. & Fink, T. 2011 Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering. Expert Opin. Biol. Ther. 11, 775-786. (doi:10.1517/14712598.2011.570258)
138. Reinlib, L. & Field, L. 2000 Cell transplantation as future therapy for cardiovascular disease? A workshop of the national heart, lung, and blood institute. Circulation 101, E182-E187.
139. Shimizu, T., Yamato, M., Isoi, Y., Akutsu, T., Setomaru, T., Abe, K., Kikuchi, A., Umezu, M. & Okano, T. 2002 Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ. Res. 90, e40-e48. (doi:10.1161/hh0302.105722)
140. Chen, Q. Z., Ishi, H., Thouas, G., Lyon, A., Wright, J. S., Harding, S. E., Boccaccini, A. R. & Harding, S. E. 2010 An elastomeric patch derived from poly(glycerol sebacate) for the delivery of embryonic stem cells to the heart. Biomaterials 31, 3885-3893. (doi:10.1016/j.biomaterials.2010.01.108)
141. Ravichandran, R., Venugopal, J., Sundarrajan, S., Mukherjee, S. & Ramakrishna, S. 2011 Poly(glycerol sebacate)/gelatin core/shell fibrous structure for regeneration of myocardial infarction. Tissue Eng. Part A 17, 1363-1373. (doi:10.1089/ten.tea.2010.0441)
142. Rappaport, D., Adam, D., Lysyansky, P. & Riesner, S. 2006 Assessment of myocardial regional strain and strain rate by tissue tracking in B-mode echocardiograms. Ultrasound Med. Biol. 32, 1181-1192. (doi:10.1016/j. ultrasmedbio.2006.05.005)
143. Bettinger, C. J., Borenstei, J. T. & Langer, R. 2006 Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer. Adv. Mater. 18, 165-169. (doi:10.1002/adma.200500438)
144. Wang, Y., Kim, Y. M. & Langer, R. 2003 In vivo degradation characteristics of poly(glycerol sebacate). J. Biomed. Mater. Res. A 66, 192-197. (doi:10.1002/jbm.a.10534)
145. Chuong, C. J., Sacks, M. S., Templeton, G., Schwiep, F. & Johnson Jr,
146. Sacks, M. S. & Chuong, C. J. 1993 Biaxial mechanical properties of passive right ventricular free wall myocardium. J. Biomech. Eng. 115, 202-205. (doi:10.1115/1.2894122)
147. Masuda, S., Shimizu, T., Yamato, M. & Okano, T. 2008 Cell sheet engineering for heart tissue repair. Adv. Drug Deliv. Rev. 60, 277-285. (doi:10.1016/j.addr.2007.08.031)
148. Kofidis, T., Lebl, D. R., Swijnenburg, R. J., Greeve, J. M., Klima, U. & Robbins, R. C. 2006 Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. Eur. J. Cardiothorac. Surg. 29, 50-55. (doi:10.1016/j.ejcts.2005.10.015)
149. Streeter Jr, D. D., Spotnitz, H. M., Patel, D. P., Ross Jr, J. & Sonnenblick, E. H. 1969 Fiber orientation in the canine left ventricle during diastole and systole. Circ. Res. 24, 339-347.
150. Seikiya, S., Shimizu, M., Yamato, T., Kikuchi, A. & Okano, T. 2006 Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. Biochem. Biophys. Res. Commun. 341, 573-582. (doi:10.1016/j.bbrc.2005.12.217)
151. Narmoneva, D. A., Vukmirovic, R., Davis, M. E., Davis, M. E., Kamm, R. D. & Lee, R. T. 2004 Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation 110, 962-968. (doi:10.1161/01.CIR.0000140667.37070.07)
152. Ryu, J. H. & Kim, I. K. 2005 Implantation of bone marrow mononuclear cells using injectable fibrin matrix enhances neovascularization in infarcted myocardium. Biomaterials 26, 319-326. (doi:10.1016/j.biomaterials.2004.02.058)
153. Kofidis, T., Akhyari, P., Boublik, J., Theodorou, P., Fischer, S., Eschenhagen, T., Kubis, H. P. & Haverich, A. 2002 In vitro engineering of heart muscle: artificial myocardial tissue. J. Thorac. Cardiovasc. Surg. 124, 63-69. (doi:10.1067/mtc.2002.121971)
154. Bouten, C. V., Dankers, P. Y., Driessen-Mol, A., Pedron, S., Brizard, A. M. & Baaijens, F. P. 2011 Substrates for cardiovascular tissue engineering. Adv. Drug Deliv. Rev. 63, 221-241. (doi:10.1016/j.addr.2011.01.007)
155. Brown, M. A., Iyer, R. K. & Radisic, M. 2008 Pulsatile bioreactor for cardiac tissue engineering. Biotechnol. Prog. 24, 907-920. (doi:10.1002/btpr. 11)
156. Akins, R. E., Boyce, R. A., Madonna, M. L., McLaughlin, T. A. & Hartzell, C. R. 1999 Cardiac organogenesis in vitro: reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cells. Tissue Eng. 5, 103-108. (doi:10.1089/ten.1999.5.103)
157. Papadaki, M., Bursac, N., Langer, R., Vunjak-Novakovic, G. & Freed, L. E. 2001 Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. Am. J. Physiol. Heart Circ. Physiol. 280, H168-H178.
158. Li, R. K., Yau, T. M., Weisel, R. D., Mickle, D. A., Sakai, T., Choi, A. & Jia, Z. Q. 2000 Construction of a bioengineered cardiac graft. J. Thorac. Cardiovasc. Surg. 119, 368-375. (doi:10.1016/S0022-5223(00)70193-0)
159. Tsur-Gang, O., Ruvinov, E., Landa, N., Leor, J. & Cohen, S. 2009 The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction. Biomaterials 30, 189-195. (doi:10.1016/j.biomaterials.2008.09.018)
160. Rizzi, S. C., Ehrbar, M., Halstenberg, S., Raeber, G. P. & Hubbell, J. A. 2006 Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II: biofunctional characteristics. Biomacromolecules 7, 3019-3029. (doi:10.1021/bm060504a)
161. Ruvinov, E., Leor, J. & Cohen, S. 2011 The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials 32, 565-578. (doi:10.1016/j.biomaterials.2010.08.097)
162. Leor, J., Tuvia, S., Guetta, V., Manczur, F. & Cohen, S. 2009 Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in swine. J. Am. Coll. Cardiol. 54, 1014-1023. (doi:10.1016/j.jacc.2009.06.010)
163. Kelley, S. T., Malekan, R., Gorman, J. H., Jackson, B. M. & Suzuki, Y. 1999 Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction. Circulation 99, 135-142. (doi:10.1161/01.CIR.99.1.135)
164. Enomoto, Y., Gorman, J. H., Moainie, S. L., Jackson, B. M. & Plappert, T. 2005 Early ventricular restraint after myocardial infarction: extent of the wrap determines the outcome of remodeling. Ann. Thorac. Surg. 79, 881-887. (doi:10.1016/j.athoracsur.2004.05.072)
165. Yildirim, Y., Naito, H., Didie, M., Eschenhagen, T. & Zimmermann, H. 2007 Development of a biological ventricular assist device; preliminary data from a small animal model. Circulation 116(Suppl. I), I-16-I-23. (doi:10.1161/CIRCULATIONAHA.106.679688)
166. Eschenhagen, T., Zimmermann, W. H. & Kleber, A. G. 2006 Electrical coupling of cardiac myocyte cell sheets to the heart. Circ. Res. 98, 573-575. (doi:10.1161/01.RES.0000215627.13049.5d)
167. Jawad, H., Ali, N. N., Lyon, A. R., Harding, S. E. & Boccaccini, A. R. 2007 Myocardial tissue engineering: a review. J. Tissue Eng. Regen. Med. 1, 327-342. (doi:10.1002/term.46)
168. Furuta, A. & Miyoshi, S. 2006 Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart in vivo. Circ. Res. 98, 705-712. (doi:10.1161/01.RES.0000209515.59115.70)
169. Coats, A. J. 2009 Ethical authorship and publishing. Int. J. Cardiol. 131, 149-150. (doi:10.1016/j.ijcard.2008.11.048)