Three-dimensional time-of-flight secondary ion mass spectrometry imaging of a pharmaceutical in a coronary stent coating as a function of elution time

Analytical Chemistry

Volumn 81, Issue 24, 2009, Pages 9930-9940

  Fisher, Gregory L ^a   Belu, Anna M ^b   Mahoney, Christine M ^c   Wormuth, Klaus ^d   Sanada, Noriaki ^e  

^a Physical Electronics Inc Minnesota   (United States)

^b MEDTRONIC INC   (United States)

^c NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^d SurModics Inc   (United States)

^e ULVAC PHI Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3-D IMAGE; 3D CHARACTERIZATION; BULK COMPOSITIONS; CHEMICAL IMAGES; CONFOCAL RAMAN IMAGING; CORONARY STENT COATING; DRUG DISTRIBUTION; HOMOGENEOUS DISPERSIONS; MATRIX; METAL COUPONS; ORGANIC SYSTEMS; POLY(LACTIC-CO-GLYCOLIC ACID); POLYATOMIC ION SOURCES; SHORT TIME SCALE; SIROLIMUS; SPUTTER-DEPTH PROFILING; SUBSURFACE DISTRIBUTION; SUBSURFACE REGIONS; SURFACE REGION; THREE-DIMENSIONAL (3D); TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; TOF SIMS;

COATINGS; DEPTH PROFILING; ION BEAMS; ION SOURCES; IONS; MASS SPECTROMETERS; SECONDARY EMISSION; SECONDARY ION MASS SPECTROMETRY; SPECTROMETRY; X RAY PHOTOELECTRON SPECTROSCOPY;

THREE DIMENSIONAL;

COBALT 60; GLYCOLIC ACID DERIVATIVE; GOLD; POLY(LACTIC CO GLYCOLIC ACID); RAPAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORONARY STENT; DISPERSION; DRUG DISTRIBUTION; DRUG ELUTING STENT; ELUTION; MASS SPECTROMETRY; RAMAN SPECTROMETRY; SURFACE PROPERTY; THREE DIMENSIONAL TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; X RAY PHOTOELECTRON SPECTROSCOPY;

DRUG-ELUTING STENTS; GOLD; LACTIC ACID; PHARMACEUTICAL PREPARATIONS; POLYGLYCOLIC ACID; SIROLIMUS; SPECTROMETRY, MASS, SECONDARY ION; SURFACE PROPERTIES; TIME FACTORS;

EID: 72449166305     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901587k     Document Type: Article

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