Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors

Neuropharmacology

Volumn 63, Issue 6, 2012, Pages 1002-1011

  Tammimäki, Anne ^a,c   Herder, Penelope ^a   Li, Ping ^b   Esch, Caroline ^b   Laughlin, James R ^a   Akk, Gustav ^b   Stitzel, Jerry A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Alpha5 subunit; CHRNA5; Intracellular calcium; Nicotinic acetylcholine receptors; Polymorphism; Rs16969968

Indexed keywords

AEQUORIN; ASPARAGINE; ASPARTIC ACID; CALCIUM; EPIBATIDINE I 125; INOSITOL TRISPHOSPHATE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA3BETA4ALPHA5; RADIOPHARMACEUTICAL AGENT; SODIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ASSAY; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA5 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RECEPTOR GENE; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM CELL LEVEL;

ACETYLCHOLINE; AEQUORIN; ALGORITHMS; BENZAZEPINES; CALCIUM; DATA INTERPRETATION, STATISTICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PERMEABILITY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUINOXALINES; RECEPTORS, NICOTINIC;

EID: 84865262858     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.07.022     Document Type: Article

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