Yohimbine depresses excitatory transmission in bnst and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes

Neuropsychopharmacology

Volumn 37, Issue 10, 2012, Pages 2253-2266

  Conrad, Kelly L ^a   Davis, Adeola R ^a   Silberman, Yuval ^a   Sheffler, Douglas J ^a,b   Shields, Angela D ^a   Saleh, Sam A ^a   Sen, Namita ^c,d   Matthies, Heinrich J G ^a   Javitch, Jonathan A ^c   Lindsley, Craig W ^a,b   Winder, Danny G ^a,d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

norepinephrine; orexin; plasticity; reward; stress; yohimbine

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 2 [4 [5 METHYL 2 (2H 1,2,3 TRIAZOL 2 YL)BENZOYL] 1,4 DIAZEPAN 1 YL]QUINAZOLINE; 5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ADENOSINE TRIPHOSPHATE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CARBACHOL; COCAINE; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; JNJ 10397047; METHOXAMINE; NORADRENALIN; OREXIN 1 RECEPTOR; OREXIN 1 RECEPTOR ANTAGONIST; OREXIN 2 RECEPTOR ANTAGONIST; OREXIN A; PICROTOXIN; PRAZOSIN; QUINAZOLINE DERIVATIVE; REBOXETINE; RECEPTOR BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CALCIUM MOBILIZATION; COCAINE DEPENDENCE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG MECHANISM; DRUG SEEKING BEHAVIOR; EX VIVO STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROPHARMACOLOGY; NONHUMAN; PATCH CLAMP; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; STRESS; STRIA TERMINALIS;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANIMALS; BEHAVIOR, ANIMAL; COCAINE; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PATCH-CLAMP TECHNIQUES; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, NEUROPEPTIDE; REWARD; SEPTAL NUCLEI; SYNAPTIC TRANSMISSION; YOHIMBINE;

EID: 84865235653     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.76     Document Type: Article

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