Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice

Neuropharmacology

Volumn 63, Issue 6, 2012, Pages 1191-1199

  Chen, Chang Rui ^a   Zhou, Xu Zhao ^a   Luo, Yan Jia ^a   Huang, Zhi Li ^a   Urade, Yoshihiro ^b   Qu, Wei Min ^a  

^a FUDAN UNIVERSITY   (China)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

EEG; GABAA; Magnolol; Sleep; TMN; VLPO

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; DIAZEPAM; FLUMAZENIL; MAGNOLOL; PROTEIN C FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BARK; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG STRUCTURE; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; IMMUNOHISTOCHEMISTRY; MAGNOLIA OFFICINALIS; MAGNOLIACEAE; MALE; MOUSE; NERVE CELL; NONHUMAN; NONREM SLEEP; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REM SLEEP; SLEEP INDUCTION; SLEEP TIME; SLEEP WAKING CYCLE; TUBEROMAMMILLARY NUCLEUS; WAKEFULNESS;

ANIMALS; AROUSAL; BIPHENYL COMPOUNDS; DIAZEPAM; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; FLUMAZENIL; GABA MODULATORS; GENE EXPRESSION; GENES, FOS; HYPOTHALAMIC AREA, LATERAL; IMMUNOHISTOCHEMISTRY; LIGNANS; MAGNOLIA; MALE; MICE; MICE, INBRED C57BL; PLANT BARK; POLYSOMNOGRAPHY; PREOPTIC AREA; RECEPTORS, GABA-A; SLEEP; SLEEP, REM;

EID: 84865229890     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.031     Document Type: Article

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