Bioactivation of nevirapine to a reactive quinone methide: Implications for liver injury

Chemical Research in Toxicology

Volumn 25, Issue 8, 2012, Pages 1708-1719

  Sharma, Amy M ^a   Li, Yan ^b   Novalen, Maria ^a   Hayes, M Anthony ^c   Uetrecht, Jack ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Drug Development Therapure Biopharma Inc   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; ALANINE AMINOTRANSFERASE; CYTOCHROME P450 2C11; CYTOCHROME P450 3A1; CYTOCHROME P450 3A4; DEUTERIUM; HYDROGEN; METHYL GROUP; NEVIRAPINE; QUINONE DERIVATIVE; QUINONE METHIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; LIVER MICROSOME; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; OXIDATION; RAT; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; INDOLEQUINONES; MALE; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; NEVIRAPINE; OXIDATION-REDUCTION; RATS; RATS, INBRED BN; STEROID 16-ALPHA-HYDROXYLASE;

EID: 84865211587     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300172s     Document Type: Article

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