Characterization of a potential animal model of an idiosyncratic drug reaction: Nevirapine-induced skin rash in the rat

Chemical Research in Toxicology

Volumn 16, Issue 9, 2003, Pages 1078-1089

  Shenton, Jacintha M ^a   Teranishi, Munehiro ^a,e   Abu Asab, Mones S ^b   Yager, Julie A ^c   Uetrecht, Jack P ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF GUELPH   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HISTOLOGY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; RASH; RAT; SEX DIFFERENCE; SKIN TOXICITY; STRAIN DIFFERENCE;

ADMINISTRATION, ORAL; ANIMALS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ERUPTIONS; DRUG EVALUATION, PRECLINICAL; EXANTHEMA; FEMALE; FOOD; FORECASTING; HEPATOMEGALY; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED STRAINS; NEVIRAPINE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; SKIN; SPLEEN; TIME FACTORS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; LETHRINUS RUBRIOPERCULATUS; RATTUS NORVEGICUS;

EID: 0141624936     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034064+     Document Type: Article

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