Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash

Chemical Research in Toxicology

Volumn 21, Issue 9, 2008, Pages 1862-1870

  Chen, Jie ^a   Mannargudi, Baskar M ^a   Xu, Ling ^a,b   Uetrecht, Jack ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; DEUTERIUM; ENZYME INHIBITOR; NEVIRAPINE; QUINONE DERIVATIVE; SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOM; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HYDROXYLATION; INCIDENCE; LIVER TOXICITY; MALE; METABOLISM; NONHUMAN; OXIDATION; RASH; RAT; SULFATION;

ANIMALS; CHROMATOGRAPHY, LIQUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXANTHEMA; FEMALE; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NEVIRAPINE; OXIDATION-REDUCTION; RATS; RATS, INBRED BN; RATS, INBRED LEW; SENSITIVITY AND SPECIFICITY; SKIN; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TRIAZOLES;

ANIMALIA; RATTUS;

EID: 53549126339     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx800177k     Document Type: Article

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