Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of Hsp90

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Dal Piaz, Fabrizio ^a   Vassallo, Antonio ^b   Chini, Maria Giovanna ^a   Cordero, Franca M ^c   Cardona, Francesca ^c   Pisano, Claudio ^d   Bifulco, Giuseppe ^a   de Tommasi, Nunziatina ^a   Brandi, Alberto ^c  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Sigma Tau SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; LENTIGINOSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROLYSIS; HYDROPHOBICITY; IN VITRO STUDY; MASS SPECTROMETRY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; THERMODYNAMICS; THERMOSTABILITY;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALKALOIDS; ENZYME ACTIVATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMINO SUGARS; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 84865197487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043316     Document Type: Article

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