N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates is chemia-induced acute kidney injury in rat

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Tsagogiorgas, Charalambos ^a   Wedel, Johannes ^a   Hottenrott, Maximilia ^a   Schneider, Michael O ^a   Binzen, Uta ^b   Greffrath, Wolfgang ^b   Treede, Rolf Detlef ^b   Theisinger, Bastian ^c   Theisinger, Sonja ^c   Waldherr, Rüdiger ^a   Krämer, Bernhard K ^a   Thiel, Manfred ^a   Schnuelle, Peter ^a   Yard, Benito A ^a   Hoeger, Simone ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c NOVALIQ GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; DOPAMINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N OCTANOYL DOPAMINE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR AGONIST; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; HISTOPATHOLOGY; IN VITRO STUDY; INHIBITION KINETICS; KIDNEY FUNCTION; KIDNEY INNERVATION; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MONOCYTE; NERVE CELL; NONHUMAN; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RENAL PROTECTION; SPINAL GANGLION; TREATMENT OUTCOME;

ACUTE KIDNEY INJURY; ANIMALS; BLOTTING, WESTERN; DOPAMINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; NF-KAPPA B; PERIPHERAL NERVES; POLYMERASE CHAIN REACTION; RATS; TRPV CATION CHANNELS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84865181684     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043525     Document Type: Article

References (60)

1. Chertow GM, Soroko SH, Paganini EP, Cho KC, Himmelfarb J, et al. ((2006)) Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 70:: 1120--1126.
2. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, et al. ((2006)) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:: R73.
3. Kellum JA, ((2008)) Acute kidney injury. Crit Care Med 36:: S141--145.
4. Lameire N, Van Biesen W, Vanholder R, ((2008)) Acute kidney injury. Lancet 372:: 1863--1865.
5. Bonventre JV, Zuk A, ((2004)) Ischemic acute renal failure: an inflammatory disease? Kidney Int 66:: 480--485.
6. Friedewald JJ, Rabb H, ((2004)) Inflammatory cells in ischemic acute renal failure. Kidney Int 66:: 486--491.
7. Edelstein C, Schrier R (2007) Pathophysiology of ischemic acute renal injury; Schrier RW, editor. Philadelphia, Pa, USA: Lippincott Williams & Wilkins. 930-961 p.
8. Akcay A, Nguyen Q, Edelstein CL, ((2009)) Mediators of inflammation in acute kidney injury. Mediators Inflamm 2009:: 137072.
9. Zoja C, Garcia PB, Remuzzi G, ((2009)) The role of chemokines in progressive renal disease. Front Biosci 14:: 1815--1822.
10. Duke GJ, Bersten AD, ((1992)) Dopamine and renal salvage in the critically ill patient. Anaesth Intensive Care 20:: 277--287.
11. Kindgen-Milles D, Tarnow J, ((1997)) [Low dosage dopamine improves kidney function: current status of knowledge and evaluation of a controversial topic]. Anasthesiol Intensivmed Notfallmed Schmerzther 32:: 333--342.
12. Holmes CL, Walley KR, ((2003)) Bad medicine: low-dose dopamine in the ICU. Chest 123:: 1266--1275.
13. Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J, ((2000)) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356:: 2139--2143.
14. Friedrich JO, Adhikari N, Herridge MS, Beyene J, ((2005)) Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142:: 510--524.
15. Kellum JA, J MD, ((2001)) Use of dopamine in acute renal failure: a meta-analysis. Crit Care Med 29:: 1526--1531.
16. Joannidis M, Druml W, Forni LG, Groeneveld AB, Honore P, et al. ((2010)) Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the Working Group for Nephrology, ESICM. Intensive Care Med 36:: 392--411.
17. Schnuelle P, Gottmann U, Hoeger S, Boesebeck D, Lauchart W, et al. ((2009)) Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial. JAMA 302:: 1067--1075.
18. Hoeger S, Gottmann U, Liu Z, Schnuelle P, Birck R, et al. ((2007)) Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulation. Transpl Int 20:: 790--799.
19. Beck G, Brinkkoetter P, Hanusch C, Schulte J, van Ackern K, et al. ((2004)) Clinical review: immunomodulatory effects of dopamine in general inflammation. Crit Care 8:: 485--491.
20. Kapper S, Beck G, Riedel S, Prem K, Haak M, et al. ((2002)) Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines. Transplantation 74:: 253--260.
21. Connor M, Vaughan CW, Vandenberg RJ, ((2010)) N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. Br J Pharmacol 160:: 1857--1871.
22. Almasi R, Szoke E, Bolcskei K, Varga A, Riedl Z, et al. ((2008)) Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo. Life Sci 82:: 644--651.
23. Ueda K, Tsuji F, Hirata T, Takaoka M, Matsumura Y, ((2008)) Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats. J Cardiovasc Pharmacol 51:: 513--520.
24. Zhong B, Wang DH, ((2008)) N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1. Am J Physiol Heart Circ Physiol 295:: H728--735.
25. Chen CW, Lee ST, Wu WT, Fu WM, Ho FM, et al. ((2003)) Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages. Br J Pharmacol 140:: 1077--1087.
26. Kim CS, Kawada T, Kim BS, Han IS, Choe SY, et al. ((2003)) Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell Signal 15:: 299--306.
27. Sancho R, Macho A, de La Vega L, Calzado MA, Fiebich BL, et al. ((2004)) Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways. J Immunol 172:: 2341--2351.
28. Singh S, Natarajan K, Aggarwal BB, ((1996)) Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol 157:: 4412--4420.
29. Surh YJ, Han SS, Keum YS, Seo HJ, Lee SS, ((2000)) Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1. Biofactors 12:: 107--112.
30. Sancho R, Lucena C, Macho A, Calzado MA, Blanco-Molina M, et al. ((2002)) Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo. Eur J Immunol 32:: 1753--1763.
31. Losel RM, Schnetzke U, Brinkkoetter PT, Song H, Beck G, et al. ((2010)) N-octanoyl dopamine, a non-hemodyanic dopamine derivative, for cell protection during hypothermic organ preservation. PLoS One 5:: e9713.
32. Greffrath W, Kirschstein T, Nawrath H, Treede R, ((2001)) Changes in cytosolic calcium in response to noxious heat and their relationship to vanilloid receptors in rat dorsal root ganglion neurons. Neuroscience 104:: 539--550.
33. Grynkiewicz G, Poenie M, Tsien RY, ((1985)) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:: 3440--3450.
34. Jaffe EA, Nachman RL, Becker CG, Minick CR, ((1973)) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:: 2745--2756.
35. Song H, Bergstrasser C, Rafat N, Hoger S, Schmidt M, et al. (2009) The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression. Br J Pharmacol.
36. Gottmann U, Brinkkoetter PT, Bechtler M, Hoeger S, Karle C, et al. ((2006)) Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats. Kidney Int 70:: 321--328.
37. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, et al. ((1997)) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:: 816--824.
38. Greffrath W, Binzen U, Schwarz ST, Saaler-Reinhardt S, Treede RD, ((2003)) Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:: 2251--2255.
39. Wang H, Wang DH, Galligan JJ, ((2010)) P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons. Am J Physiol Regul Integr Comp Physiol 298:: R1634--1641.
40. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, et al. ((1998)) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:: 531--543.
41. Rayamajhi S, Contractor T, Wang DH, ((2009)) The potential of TRPV1 agonists for treating ischemia/reperfusion-induced renal injuries. Curr Opin Investig Drugs 10:: 963--970.
42. Feng NH, Lee HH, Shiang JC, Ma MC, ((2008)) Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys. Am J Physiol Renal Physiol 294:: F316--325.
43. Ditting T, Tiegs G, Rodionova K, Reeh PW, Neuhuber W, et al. ((2009)) Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney? Am J Physiol Renal Physiol 297:: F1427--1434.
44. Legrand M, Mik EG, Johannes T, Payen D, Ince C, ((2008)) Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med 14:: 502--516.
45. Katki KA, Supowit SC, DiPette DJ, ((2001)) Role of calcitonin gene-related peptide and substance P in Dahl-salt hypertension. Hypertension 38:: 679--682.
46. Wang M, Peng J, Wang R, Zhao L, Xia Z (2010) TRPV1 Agonist Capsaicin Attenuates Lung Ischemia-Reperfusion Injury in Rabbits. J Surg Res.
47. Szabo A, Helyes Z, Sandor K, Bite A, Pinter E, et al. ((2005)) Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. J Pharmacol Exp Ther 314:: 111--119.
48. Keeble J, Russell F, Curtis B, Starr A, Pinter E, et al. ((2005)) Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. Arthritis Rheum 52:: 3248--3256.
49. Demirbilek S, Ersoy MO, Karaman A, Gurbuz N, Bayraktar N, et al. (2004) Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth Analg 99: 1501-1507; table of contents.
50. Szallasi A, Cortright DN, Blum CA, Eid SR, ((2007)) The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6:: 357--372.
51. Alawi K, Keeble J, ((2010)) The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther 125:: 181--195.
52. Navarrete CM, Perez M, de Vinuesa AG, Collado JA, Fiebich BL, et al. ((2010)) Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway. Biochem Pharmacol 79:: 1805--1814.
53. Cao CC, Ding XQ, Ou ZL, Liu CF, Li P, et al. ((2004)) In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int 65:: 834--845.
54. Azuma H, Tomita N, Kaneda Y, Koike H, Ogihara T, et al. ((2003)) Transfection of NFkappaB-decoy oligodeoxynucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts. Gene Ther 10:: 415--425.
55. Nath KA, Norby SM, ((2000)) Reactive oxygen species and acute renal failure. Am J Med 109:: 665--678.
56. Chatterjee PK, Cuzzocrea S, Brown PA, Zacharowski K, Stewart KN, et al. ((2000)) Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 58:: 658--673.
57. Yamanobe T, Okada F, Iuchi Y, Onuma K, Tomita Y, et al. ((2007)) Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice. Free Radic Res 41:: 200--207.
58. Singh D, Kaur R, Chander V, Chopra K, ((2006)) Antioxidants in the prevention of renal disease. J Med Food 9:: 443--450.
59. Guo Q, Zhao B, Li M, Shen S, Xin W, ((1996)) Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta 1304:: 210--222.
60. Brinkkoetter PT, Beck GC, Gottmann U, Loesel R, Schnetzke U, et al. ((2006)) Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activation. Transplantation 82:: 534--542.