Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5707-5713

  Skouta, Rachid ^a   Hayano, Miki ^a   Shimada, Kenichi ^a   Stockwell, Brent R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Non apoptotic; Pictet Spengler; RAS; Structure activity relationship (SAR); Synthetic lethal; Tetrahydro carboline

Indexed keywords

ANTIOXIDANT; CARBOLINE DERIVATIVE; CASPASE; ERASTIN; ML 162; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; LETHALITY; ONCOGENE RAS; PICTET SPENGLER REACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CARBOLINES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; NEOPLASMS;

EID: 84865150462     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.077     Document Type: Article

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