CANCER CHEMOTHERAPY;
CANCER PATIENT;
CANCER SURVIVAL;
CLINICAL TRIAL;
DRUG APPROVAL;
DRUG CLASSIFICATION;
DRUG INDICATION;
DRUG MECHANISM;
FOOD AND DRUG ADMINISTRATION;
HUMAN;
LUNG NON SMALL CELL CANCER;
NOTE;
PRIORITY JOURNAL;
TREATMENT FAILURE;
UNITED STATES;
ADMINISTRATION, ORAL;
ANTINEOPLASTIC AGENTS;
ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS;
CARCINOMA, NON-SMALL-CELL LUNG;
CLINICAL TRIALS, PHASE III;
DRUG ADMINISTRATION SCHEDULE;
DRUG DELIVERY SYSTEMS;
DRUG DESIGN;
DRUG SCREENING ASSAYS, ANTITUMOR;
EXPERT TESTIMONY;
HUMANS;
QUINAZOLINES;
RANDOMIZED CONTROLLED TRIALS;
RECEPTOR, EPIDERMAL GROWTH FACTOR;
TAXOIDS;
TIME FACTORS;
TREATMENT OUTCOME;
Issues and progress with protein kinase inhibitors for the treatment of cancer
Dancey, J. & Sausville, E. A. Issues and progress with protein kinase inhibitors for the treatment of cancer. Nature Rev. Drug Discov. 2, 296-313 (2003).
Epidermal growth factor-related peptides and their receptors in human malignancies
Salomon, D. S. et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol Hematol. 19, 183-232 (1995).
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
Moyer, J. D. et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57, 4838-4848 (1997).
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
Pollack, V. A. et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J. Pharmacol. Exp. Ther. 291 739-748 (1999).
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl J. Med. 350, 2129-2139 (2004).
Clinical and biological features of epidermal growth factor receptor mutations in lung cancers
(in the press)
Shigematsu, H. et al. Clinical and biological features of epidermal growth factor receptor mutations in lung cancers. J. Natl Cancer Inst. (in the press).
Phase I/II trial evaluating the anti-VEGF MAb bevacizumab in combination with erlotinib, a HER1/EGFR-TK inhibitor, for patients with recurrent non-small call lung cancer
Sandler, A. et al. Phase I/II trial evaluating the anti-VEGF MAb bevacizumab in combination with erlotinib, a HER1/EGFR-TK inhibitor, for patients with recurrent non-small call lung cancer. J. Clin. Oncol. 22, 14S (2004).
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and edotinib
Pao, W. et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and edotinib. Proc. Natl Acad. Sci. USA 101, 13306-13311 (2004).