Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens

Journal of the American Chemical Society

Volumn 134, Issue 32, 2012, Pages 13192-13195

  Biggins, John B ^a   Ternei, Melinda A ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BACTERIAL GENOMES; BIOSYNTHETIC GENE CLUSTER; BURKHOLDERIA; BURKHOLDERIA PSEUDOMALLEI; CYTOTOXIC; GENE CLUSTERS; MELIOIDOSIS; METABOLOMES; NATURAL PRODUCTS; POLYKETIDES; PROMOTER EXCHANGES; SIDEROPHORES; SMALL MOLECULES; VIRULENCE FACTORS;

BIOCHEMISTRY; FERMENTATION;

GENES;

AMINOSALICYLIC ACID; ANTIBIOTIC AGENT; MALLEILACTONE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BIOSYNTHESIS; BURKHOLDERIA PSEUDOMALLEI; CONTROLLED STUDY; CRYPTIC (ERA); EXPERIMENT; FERMENTATION; GENE CLUSTER; GLANDERS; HUMAN; HUMAN CELL; MELIOIDOSIS; METABOLOME; NONHUMAN; PATHOGENESIS;

BURKHOLDERIA PSEUDOMALLEI; CELL LINE; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; METABOLOME; MODELS, BIOLOGICAL; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; PROMOTER REGIONS, GENETIC; VIRULENCE FACTORS;

EID: 84865138150     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3052156     Document Type: Article

References (29)

1. Galyov, E. E.; Brett, P. J.; DeShazer, D. Annu. Rev. Microbiol. 2010, 64, 495
2. Limmathurotsakul, D.; Wongratanacheewin, S.; Teerawattansook, N.; Wongsuvan, G.; Chaisuksant, S.; Chetchotisakd, P.; Chaowagul, W.; Day, N. P.; Peacock, S. J. Am. J. Trop. Med. Hyg. 2010, 82, 1113
3. Bassler, B. L.; Losick, R. Cell 2006, 125, 237
4. Gomez, J. E.; Clatworthy, A.; Hung, D. T. Crit. Rev. Biochem. Mol. Biol. 2011, 46, 41
5. Zerikly, M.; Challis, G. L. Chembiochem 2009, 10, 625
6. Nierman, W. C. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 14246
7. Kim, H. S.; Schell, M. A.; Yu, Y.; Ulrich, R. L.; Sarria, S. H.; Nierman, W. C.; DeShazer, D. BMC Genomics 2005, 6, 174
8. Yu, Y. BMC Microbiol. 2006, 6, 46
9. Sifri, C. D.; Begun, J.; Ausubel, F. M. Trends Microbiol. 2005, 13, 119
10. O'Quinn, A. L.; Wiegand, E. M.; Jeddeloh, J. A. Cell Microbiol. 2001, 3, 381
11. Lee, S. H.; Ooi, S. K.; Mahadi, N. M.; Tan, M. W.; Nathan, S. PLoS One 2011, 6, e16707
12. Hasselbring, B. M.; Patel, M. K.; Schell, M. A. Infect. Immun. 2011, 79, 2079
13. Steinert, M.; Heuner, K. Cell Microbiol. 2005, 7, 307
14. Bozzaro, S.; Eichinger, L. Curr. Drug Targets 2011, 12, 942
15. Biggins, J. B.; Liu, X.; Feng, Z.; Brady, S. F. J. Am. Chem. Soc. 2011, 133, 1638
16. Biggins, J. B.; Gleber, C. D.; Brady, S. F. Org. Lett. 2011, 13, 1536
17. Cardona, S. T.; Valvano, M. A. Plasmid 2005, 54, 219
18. Crews, P.; Rodriguez, J.; Jaspars, M. Organic Structure Analysis; Oxford University Press: New York, 1998.
19. Pretch, E.; Bühlmann, P.; Affolter, C. Structure Determination of Organic Compounds: Tables of Spectral Data; Springer: Berlin, 2000.
20. Emmert, E. A.; Klimowicz, A. K.; Thomas, M. G.; Handelsman, J. Appl. Environ. Microbiol. 2004, 70, 104
21. Chan, Y. A.; Boyne, M. T., II; Podevels, A. M.; Klimowicz, A. K.; Handelsman, J.; Kelleher, N. L.; Thomas, M. G. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 14349
22. Lin, S.; Van Lanen, S. G.; Shen, B. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4183
23. Du, L.; Lou, L. Nat. Prod. Rep. 2010, 27, 255
24. Ulrich, R. L.; Hines, H. B.; Parthasarathy, N.; Jeddeloh, J. A. J. Bacteriol. 2004, 186, 4350
25. Schobert, R.; Schlenk, A. Bioorg. Med. Chem. 2008, 16, 4203
26. Ulrich, R. L.; Deshazer, D.; Brueggemann, E. E.; Hines, H. B.; Oyston, P. C.; Jeddeloh, J. A. J. Med. Microbiol. 2004, 53, 1053
27. Ulrich, R. L.; Deshazer, D.; Hines, H. B.; Jeddeloh, J. A. Infect. Immun. 2004, 72, 6589
28. Miethke, M.; Marahiel, M. A. Microbiol. Mol. Biol. Rev. 2007, 71, 413
29. Nagachar, N.; Ratledge, C. FEMS Microbiol. Lett. 2010, 311, 193 and references therein