Complete killing of Caenorhabditis elegans by Burkholderia pseudomallei is dependent on prolonged direct association with the viable pathogen

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Lee, Song Hua ^a   Ooi, Soon Keat ^a   Mahadi, Nor Muhammad ^b   Tan, Man Wah ^c   Nathan, Sheila ^a,b  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b MALAYSIA GENOME INSTITUTE   (Malaysia)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; GLUCOSE; GREEN FLUORESCENT PROTEIN; PEPTONE; TOXIN;

ARTICLE; BACTERIAL CELL; BACTERIAL VIRULENCE; BACTERIUM CULTURE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BURKHOLDERIA PSEUDOMALLEI; CAENORHABDITIS ELEGANS; CELL FREE SYSTEM; CONTROLLED STUDY; CULTURE MEDIUM; ENVIRONMENTAL FACTOR; GENOTYPE ENVIRONMENT INTERACTION; HOST PATHOGEN INTERACTION; MALAYSIA; NONHUMAN; PROTEIN EXPRESSION; SOIL ORGANISM; TOXIN SYNTHESIS; ANIMAL; DIFFUSION; DISEASE PREDISPOSITION; ENVIRONMENT; GASTROINTESTINAL TRACT; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; PATHOLOGY;

ANIMALIA; BURKHOLDERIA; BURKHOLDERIA PSEUDOMALLEI; CAENORHABDITIS ELEGANS;

ANIMALS; BURKHOLDERIA PSEUDOMALLEI; CAENORHABDITIS ELEGANS; DIFFUSION; DISEASE SUSCEPTIBILITY; ENVIRONMENT; GASTROINTESTINAL TRACT; HOST-PATHOGEN INTERACTIONS; HUMANS; MICE; TOXINS, BIOLOGICAL;

EID: 79952343935     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016707     Document Type: Article

References (34)

1. Tan MW, Mahajan-Miklos S, Ausubel FM, (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A 96: 715-720.
2. Aballay A, Yorgey P, Ausubel FM, (2000) Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans. Curr Biol 10: 1539-1542.
3. Labrousse A, Chauvet S, Couillault C, Kurz CL, Ewbank JJ, (2000) Caenorhabditis elegans is a model host for Salmonella typhimurium. Curr Biol 10: 1543-1545.
4. Schulenburg H, Ewbank JJ, (2004) Diversity and specificity in the interaction between Caenorhabditis elegans and the pathogen Serratia marcescens. BMC Evolutionary Biol 4: 49.
5. O'Quinn AL, Wiegand EM, Jeddeloh JA, (2001) Burkholderia pseudomallei kills the nematode Caenorhabditis elegans using an endotoxin-mediated paralysis. Cell Microbiol 3 (6): 381-393.
6. Kothe M, Antl M, Huber B, Stoecker K, Ebrecht D, et al. (2003) Killing of Caenorhabditis elegans by Burkholderia cepacia is controlled by the cep quorum-sensing system. Cell Microbiol 5 (5): 343-351.
7. Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, et al. (2001) A simple model host for identifying Gram-positive virulence factors. Proc Natl Acad Sci U S A 98: 10892-10897.
8. Jansson HB, (1994) Adhesion of conida of Drechmeria coniospora to Caenorhabditis elegans wild type and mutants. J Nematol 26: 430-435.
9. Darby C, Hsu JW, Ghori N, Falkow S, (2002) Caenorhabditis elegans: plague bacteria biofilm blocks food intake. Nature 417: 243-244.
10. Cheng AC, Currie BJ, (2005) Melioidosis: epidemiology, pathophysiology and management. Clin Microbiol Rev 18: 383-416.
11. Dance DAB, (1991) Melioidosis: the tip of the iceberg? Clinic Microbiol Rev 4 (1): 52-60.
12. Wiersinga WJ, Poll TVD, White NJ, Day NP, Peacock SJ, (2006) Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol 4: 272-282.
13. Currie BJ, Fisher DA, Anstey NM, Jacups SP, (2000) Melioidosis: acute and chronic disease, relapse and re-activation. Trans R Soc Trop Med Hyg 94 (3): 301-304.
14. Ngauy V, Lemeshev Y, Sadkowski L, Crawford G, (2005) Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War II. J Clin Microbiol 43 (2): 970-972.
15. Chauwagul W, (2000) Recent advances in the treatment of severe melioidosis. Acta Tropica 74 (2-3): 133-137.
16. Gan YH, Chua KL, Chua HH, Liu BP, Hii CS, et al. (2002) Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system. Mol Microbiol 44 (5): 1185-1197.
17. Ashcroft A, Golden A, (2002) CDC-25.1 regulates germline proliferation in Caenorhabditis elegans. Genesis 3: 1-7.
18. Lee SH, Chong CE, Lim BS, Chai SJ, Sam KK, et al. (2007) Burkholderia pseudomallei animal and human isolates from Malaysia exhibit different phenotypic characteristics. Diag Microbiol Infect Dis 58: 263-270.
19. Miller JF, Mekalanos JJ, Falkow S, (1989) Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243: 916-922.
20. Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM, (1999) Molecular mechanism of bacterial virulence elucidated using a Pseudomonas aeruginosa- Caenorhabditis elegans pathogenesis model. Cell 96: 47-56.
21. Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297: 623-626.
22. Sifri CD, Begun J, Ausubel FM, Calderwood SB, (2003) Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun 71: 2208-2217.
23. Holden MTG, Titball RW, Peacock SJ, Cerdeno-Tarraga AM, Atkins T, et al. (2004) Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A 101 (39): 14240-14245.
24. Ulett GC, Currie BJ, Clait TW, Mayo M, Ketheesan N, et al. (2001) Burkholderia pseudomallei virulence: definition, stability and association with clonality. Microbiol Infect 3: 621-631.
25. Ou K, Ong C, Koh SY, Rodrigues F, Sim SH, et al. (2005) Integrative genomic, transcriptional and proteomic diversity in natural isolates of the human pathogen Burkholderia pseudomallei. J Bacteriol 187: 4276-4285.
26. Titball RW, Russell P, Cuccui J, Easton A, Haque A, et al. (2008) Burkholderia pseudomallei: animal models of infection. Trans Royal Soc of Trop Med Hyg 102 (S1): 111-116.
27. Bleich A, Mähler M, (2005) Environment as a critical factor for the pathogenesis and outcome of gastrointestinal disease: experimental and human inflammatory bowel disease and Helicobacter-induced gastritis. Pathobiol 72 (6): 293-307.
28. Milenbachs AA, Brown DP, Moors M, Youngman P, (1997) Carbon-source regulation of virulence gene expression in Listeria monocytogenes. Mol Microbiol 23: 1075.
29. Balaji V, Jesudason MV, Sridharan G, Subramanian K, (2004) Detection of virulence attributes of Burkholderia pseudomallei. Ind J Med Res pp. 101-106.
30. Sim SH, Yu Y, Lin CH, Karuturi RK, Wuthiekanun V, et al. (2008) The core and accessory genomes of Burkholderia pseudomallei: implications for human melioidosis. PLoS Pathogens 4 (10): 1-10.
31. Ashdown LR, (1979) An improved screening technique for isolation of Pseudomonas pseudomallei from clinical specimens. Pathology 11: 293-297.
32. Brenner S, (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
33. Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J, (2000) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2 (1): research0002.1-0002.10.
34. Wixton J, Blaxter M, Hope I, Barstead R, Kim S, (2000) Caenorhabditis elegans. Yeast 17: 37-42.