Quorum sensing: A transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei

Infection and Immunity

Volumn 72, Issue 11, 2004, Pages 6589-6596

  Ulrich, Ricky L ^a,b   DeShazer, David ^a   Hines, Harry B ^a   Jeddeloh, Jeffrey A ^a,c  

^a Dept of Immunol and Molec Biology Bldg 1425 U States Army Med R   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c Orion Genomics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOSERINE; LACTONE DERIVATIVE; N DECANOYLHOMOSERINE LACTONE; N OCTANOYLHOMOSERINE LACTONE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOSYNTHESIS; BMAI1 GENE; BMAI3 GENE; BMAR5 GENE; BURKHOLDERIA; BURKHOLDERIA MALLEI; CELL DENSITY; CONTROLLED STUDY; DELETION MUTANT; FEMALE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE MUTATION; GRAM NEGATIVE BACTERIUM; LD 50; LUXI GENE; LUXR GENE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PRIORITY JOURNAL; QUORUM SENSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURVIVAL; SYRIAN HAMSTER; TRANSCRIPTION REGULATION; WILD TYPE;

4-BUTYROLACTONE; ANIMALS; BACTERIAL PROTEINS; BURKHOLDERIA MALLEI; CRICETINAE; GENE EXPRESSION REGULATION, BACTERIAL; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOMOSERINE; HUMANS; LACTONES; MESOCRICETUS; MICE; MICE, INBRED BALB C; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRULENCE FACTORS;

EID: 7044220518     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.11.6589-6596.2004     Document Type: Article

References (39)

1. Adam Baldwin, P. A. S., J. Parkhill, and E. Mahenthiralingam. 2004. The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia. Infect. Immun. 72:1537-1547.
2. Camara, M., P. Williams, and A. Hardman. 2002. Controlling infection by tuning in and turning down the volume of bacterial small-talk. Lancet Infect. Dis. 2:667-676.
3. Conway, B. A., and E. P. Greenberg. 2002. Quorum-sensing signals and quorum-sensing genes in Burkholderia vietnamiensis. J. Bacteriol. 184:1187-1191.
4. DeShazer, D., and D. Waag. Glanders: new insights into an old disease. In L. Lindler, F. Lebeda, and G. W. Korch (ed.). Biological weapons defense: infectious diseases and counterbioterrorism, in press. The Humana Press Inc., Totowa, N.J.
5. DeShazer, D., D. M. Waag, D. L. Fritz, and D. E. Woods. 2001. Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinant. Microb. Pathog. 30:253-269.
6. Donabedian, H. 2003. Quorum sensing and its relevance to infectious diseases. J. Infect. 46:207-214.
7. Dunn, A. K., and J. Handelsman. 2002. Toward an understanding of microbial communities through analysis of communication networks. Antonie Leeuwenhoek 81:565-574.
8. Flavier, A. B., L. M. Ganova-Raeva, M. A. Schell, and T. P. Denny. 1997. Hierarchical autoinduction in Ralstonia solanacearum: control of acyl-homoserine lactone production by a novel autoregulatory system responsive to 3-hydroxypalmitic acid methyl ester. J. Bacteriol. 179:7089-7097.
9. Fritz, D. L., P. Vogel, D. R. Brown, D. Deshazer, and D. M. Waag. 2000. Mouse model of sublethal and lethal intraperitoneal glanders (Burkholderia mallei). Vet. Pathol. 37:626-636.
10. Fuqua, C., M. R. Parsek, and E. P. Greenberg. 2001. Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Annu. Rev. Genet. 35:439-468.
11. Fuqua, C., and S. C. Winans. 1996. Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes. J. Bacteriol. 178:435-440.
12. Fuqua, C., S. C. Winans, and E. P. Greenberg. 1996. Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators. Annu. Rev. Microbiol. 50:727-751.
13. Fuqua, W. C., S. C. Winans, and E. P. Greenberg. 1994. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176:269-275.
14. Godoy, D., G. Randle, A. J. Simpson, D. M. Aanensen, T. L. Pitt, R. Kinoshita, and B. G. Spratt. 2003. Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. J. Clin. Microbiol. 41:2068-2079.
15. Gotschlich, A., B. Huber, O. Geisenberger, A. Togl, A. Steidle, K. Riedel, P. Hill, B. Tummler, P. Vandamme, B. Middleton, M. Camara, P. Williams, A. Hardman, and L. Eberl. 2001. Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex. Syst. Appl. Microbiol. 24:1-14.
16. Gray, K. M., and J. R. Garey. 2001. The evolution of bacterial LuxI and LuxR quorum sensing regulators. Microbiology 147:2379-2387.
17. Hardman, A. M., G. S. Stewart, and P. Williams. 1998. Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria. Antonie Leeuwenhoek 74:199-210.
18. Huber, B., K. Riedel, M. Hentzer, A. Heydorn, A. Gotschlich, M. Givskov, S. Molin, and L. Eberl. 2001. The cep quorum-sensing system of Burkholderia cepacia Hill controls biofilm formation and swarming motility. Microbiology 147:2517-2528.
19. Jeddeloh, J. A., D. L. Fritz, D. M. Waag, J. M. Hartings, and G. P. Andrews. 2003. Biodefense-driven murine model of pneumonic melioidosis. Infect. Immun. 71:584-587.
20. Lewenza, S., B. Conway, E. P. Greenberg, and P. A. Sokol. 1999. Quorum sensing in Burkholderia cepacia: identification of the LuxRI homologs CepRI. J. Bacteriol. 181:748-756.
21. Lewenza, S., and P. A. Sokol. 2001. Regulation of ornibactin biosynthesis and N-acyl-L-homoserine lactone production by CepR in Burkholderia cepacia. J. Bacteriol. 183:2212-2218.
22. Miller, W. R., L. Pannell, L. Cravitz, W. A. Tanner, and T. Rosebury. 1947. Studies on certain biological characteristics of Malleomyces mallei and Malleomyces pseudomallei. J. Bacteriol. 55:115-126.
23. Parsek, M. R., A. L. Schaefer, and E. P. Greenberg. 1997. Analysis of random and site-directed mutations in rhII, a Pseudomonas aeruginosa gene encoding an acylhomoserine lactone synthase. Mol. Microbiol. 26:301-310.
24. Roy, C. J., M. Hale, J. M. Hartings, L. Pitt, and S. Duniho. 2003. Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice. Inhal. Toxicol. 15:619-638.
25. Rumbaugh, K. P., J. A. Griswold, and A. N. Hamood. 2000. The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa. Microbes Infect. 2:1721-1731.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Schuster, M., C. P. Lostroh, T. Ogi, and E. P. Greenberg. 2003. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185:2066-2079.
28. Shaw, P. D., G. Ping, S. L. Daly, C. Cha, J. E. Cronan, Jr., K. L. Rinehart, and S. K. Farrand. 1997. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography. Proc. Natl. Acad. Sci. USA 94:6036-6041.
29. Simon, R., U. Priefer, and A. Pühler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram-negative bacteria. Biotechnology 1:784-791.
30. Smith, R. S., and B. H. Iglewski. 2003. Pseudomonas aeruginosa quorum-sensing systems and virulence. Curr. Opin. Microbiol. 6:56-60.
31. Sokol, P. A., U. Sajjan, M. B. Visser, S. Gingues, J. Forstner, and C. Kooi. 2003. The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections. Microbiology 149:3649-3658.
32. Ulrich, R. L. Quorum quenching: Enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis. Appl. Environ. Microbiol., in press.
33. Ulrich, R. L., and D. DeShazer. 2004. Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei. Infect. Immun. 72:1150-1154.
34. Ulrich, R. L., D. DeShazer, E. E. Brueggemann, H. B. Mines, P. C. Oyston, and J. A. Jeddeloh. The role of quorum sensing in the pathogenicity of Burkholderia pseudomallei. J. Med. Microbiol., in press.
35. Ulrich, R. L., H. B. Mines, N. Parthasarathy, and J. A. Jeddeloh. 2004. Mutational analysis and biochemical characterization of the Burkholderia thailandensis DW503 quorum-sensing network. J. Bacteriol. 186:4350-4360.
36. Valade, E., F. M. Thibault, Y. P. Gauthier, M. Palencia, M. Y. Popoff, and D. R. Vidal. 2004. The PmlI-PmlR quorum-sensing system in Burkholderia pseudomallei plays a key role in virulence and modulates production of the MprA protease. J. Bacteriol. 186:2288-2294.
37. Von Bodman, S. B., W. D. Bauer, and D. L. Coplin. 2003. Quorum sensing in plant-pathogenic bacteria. Annu. Rev. Phytopathol. 41:455-482.
38. Waag, D., J. Chulay, T. Marrie, M. England, and J. Williams. 1995. Validation of an enzyme immunoassay for serodiagnosis of acute Q fever. Eur. J. Clin. Microbiol. Infect. Dis. 14:421-427.
39. Wagner, V. E., D. Bushnell, L. Passador. A. I. Brooks, and B. H. Iglewski. 2003. Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol. 185:2080-2095.