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Volumn 61, Issue 9, 2012, Pages 1021-1029

Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment

Author keywords

Antigen induced arthritis; Cathepsin L; Cathepsin V; Rheumatoid arthritis; T helper cells

Indexed keywords

ANTIGEN; CATHEPSIN L; CATHEPSIN V;

EID: 84865136781     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0495-x     Document Type: Article
Times cited : (23)

References (41)
  • 1
    • 0038131975 scopus 로고    scopus 로고
    • Therapeutic strategies for rheumatoid arthritis
    • DOI 10.1038/nrd1109
    • Smolen JS, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003;2(6):473-88. (Pubitemid 37361728)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.6 , pp. 473-488
    • Smolen, J.S.1    Steiner, G.2
  • 2
    • 19544384628 scopus 로고    scopus 로고
    • Synovial activation in rheumatoid arthritis
    • Ospelt C, Neidhart M, Gay RE, Gay S. Synovial activation in rheumatoid arthritis. Front Biosci. 2004;9:2323-34.
    • (2004) Front Biosci , vol.9 , pp. 2323-2334
    • Ospelt, C.1    Neidhart, M.2    Gay, R.E.3    Gay, S.4
  • 3
    • 29244438790 scopus 로고    scopus 로고
    • Where do T cells stand in rheumatoid arthritis?
    • DOI 10.1016/j.jbspin.2004.12.012, PII S1297319X05000825
    • Fournier C. Where do T cells stand in rheumatoid arthritis? Joint Bone Spine. 2005;72(6):527-32. (Pubitemid 41821411)
    • (2005) Joint Bone Spine , vol.72 , Issue.6 , pp. 527-532
    • Fournier, C.1
  • 5
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • DOI 10.1038/nri2094, PII NRI2094
    • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7(6):429-42. (Pubitemid 46834849)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.6 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 7
    • 0034881924 scopus 로고    scopus 로고
    • Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis
    • DOI 10.1002/1529-0131(200108)44:8<1744::AID-ART309>3.0.CO;2-K
    • Cunnane G, FitzGerald O, Hummel KM, Youssef PP, Gay RE, Gay S, et al. Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Arthritis Rheum. 2001;44(8): 1744-53. (Pubitemid 32758219)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.8 , pp. 1744-1753
    • Cunnane, G.1    Fitzgerald, O.2    Hummel, K.M.3    Youssef, P.P.4    Gay, R.E.5    Gay, S.6    Bresnihan, B.7
  • 8
    • 77952798828 scopus 로고    scopus 로고
    • Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis
    • Pozgan U, Caglic D, Rozman B, Nagase H, Turk V, Turk B. Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem. 2010;391(5):571-9.
    • (2010) Biol Chem. , vol.391 , Issue.5 , pp. 571-579
    • Pozgan, U.1    Caglic, D.2    Rozman, B.3    Nagase, H.4    Turk, V.5    Turk, B.6
  • 9
    • 0021344717 scopus 로고
    • Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH
    • Mort JS, Recklies AD, Poole AR. Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH. Arthritis Rheum. 1984;27(5):509-15. (Pubitemid 14140024)
    • (1984) Arthritis and Rheumatism , vol.27 , Issue.5 , pp. 509-515
    • Mort, J.S.1    Recklies, A.D.2    Poole, A.R.3
  • 14
    • 65749098196 scopus 로고    scopus 로고
    • Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice
    • Svelander L, Erlandsson-Harris H, Astner L, Grabowska U, Klareskog L, Lindstrom E, et al. Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice. Eur J Pharmacol. 2009;613(1-3):155-62.
    • (2009) Eur J Pharmacol , vol.613 , Issue.1-3 , pp. 155-162
    • Svelander, L.1    Erlandsson-Harris, H.2    Astner, L.3    Grabowska, U.4    Klareskog, L.5    Lindstrom, E.6
  • 15
    • 4344670363 scopus 로고    scopus 로고
    • Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages
    • DOI 10.1074/jbc.M403986200
    • Yasuda Y, Li Z, Greenbaum D, Bogyo M, Weber E, Bromme D. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem. 2004;279(35):36761-70. (Pubitemid 39129024)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.35 , pp. 36761-36770
    • Yasuda, Y.1    Li, Z.2    Greenbaum, D.3    Bogyo, M.4    Weber, E.5    Bromme, D.6
  • 16
    • 0025269177 scopus 로고
    • Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B
    • Nguyen Q, Mort JS, Roughley PJ. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem J. 1990;266(2):569-73. (Pubitemid 20090162)
    • (1990) Biochemical Journal , vol.266 , Issue.2 , pp. 569-573
    • Nguyen, Q.1    Mort, J.S.2    Roughley, P.J.3
  • 18
    • 37549072689 scopus 로고    scopus 로고
    • Cell type-specific functions of the lysosomal protease cathepsin L in the heart
    • Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Hagemann S, et al. Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. 2007;282(51): 37045-52.
    • (2007) J Biol Chem , vol.282 , Issue.51 , pp. 37045-37052
    • Spira, D.1    Stypmann, J.2    Tobin, D.J.3    Petermann, I.4    Mayer, C.5    Hagemann, S.6
  • 19
    • 0031829713 scopus 로고    scopus 로고
    • Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis
    • DOI 10.1002/1529-0131(199808)41:8<1378::AID-ART6>3.0.CO;2-J
    • Keyszer G, Redlich A, Haupl T, Zacher J, Sparmann M, Engethum U, et al. Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. Arthritis Rheum. 1998;41(8):1378-87. (Pubitemid 28373116)
    • (1998) Arthritis and Rheumatism , vol.41 , Issue.8 , pp. 1378-1387
    • Keyszer, G.1    Redlich, A.2    Haupl, T.3    Zacher, J.4    Sparmann, M.5    Ungethum, U.6    Gay, S.7    Burmester, G.R.8
  • 20
    • 0035079963 scopus 로고    scopus 로고
    • Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor
    • DOI 10.1002/1529-0131(200103)44:3<703::AID-ANR120>3.0.CO;2-2
    • Biroc SL, Gay S, Hummel K, Magill C, Palmer JT, Spencer DR, et al. Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor. Arthritis Rheum. 2001;44(3):703-11. (Pubitemid 32234630)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.3 , pp. 703-711
    • Biroc, S.L.1    Gay, S.2    Hummel, K.3    Magill, C.4    Palmer, J.T.5    Spenc, D.R.6    Sa, S.7    Klaus, J.L.8    Michel, B.A.9    Rasnick, D.10    Gay, R.E.11
  • 23
    • 70449336081 scopus 로고    scopus 로고
    • Diverse regulatory roles for lysosomal proteases in the immune response
    • Colbert JD, Matthews SP, Miller G, Watts C. Diverse regulatory roles for lysosomal proteases in the immune response. Eur J Immunol. 2009;39(11):2955-65.
    • (2009) Eur J Immunol , vol.39 , Issue.11 , pp. 2955-2965
    • Colbert, J.D.1    Matthews, S.P.2    Miller, G.3    Watts, C.4
  • 25
    • 0037810382 scopus 로고    scopus 로고
    • Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors
    • DOI 10.1515/BC.2003.099
    • Katunuma N, Matsunaga Y, Himeno K, Hayashi Y. Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors. Biol Chem. 2003;384(6):883-90. (Pubitemid 36874502)
    • (2003) Biological Chemistry , vol.384 , Issue.6 , pp. 883-890
    • Katunuma, N.1    Matsunaga, Y.2    Himeno, K.3    Hayashi, Y.4
  • 27
    • 78149359763 scopus 로고    scopus 로고
    • Expression of human cathepsin L or human cathepsin v in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
    • Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T. Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie. 2010;92(11):1674-80.
    • (2010) Biochimie. , vol.92 , Issue.11 , pp. 1674-1680
    • Sevenich, L.1    Hagemann, S.2    Stoeckle, C.3    Tolosa, E.4    Peters, C.5    Reinheckel, T.6
  • 28
    • 33645080974 scopus 로고    scopus 로고
    • Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis
    • Schurigt U, Stopfel N, Huckel M, Pfirschke C, Wiederanders B, Brauer R. Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis. Arthritis Res Ther. 2005;7(1):R174-88.
    • (2005) Arthritis Res Ther , vol.7 , Issue.1
    • Schurigt, U.1    Stopfel, N.2    Huckel, M.3    Pfirschke, C.4    Wiederanders, B.5    Brauer, R.6
  • 29
    • 38449089583 scopus 로고    scopus 로고
    • Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response
    • Irmler IM, Gajda M, Brauer R. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J Immunol. 2007;179(9):6228-36.
    • (2007) J Immunol , vol.179 , Issue.9 , pp. 6228-6236
    • Irmler, I.M.1    Gajda, M.2    Brauer, R.3
  • 30
    • 0033810653 scopus 로고    scopus 로고
    • Cathepsin L deficiency as molecular defect of furless: Hyperproliferation of keratinocytes and pertubation of hair follicle cycling
    • Roth W, Deussing J, Botchkarev VA, Pauly-Evers M, Saftig P, Hafner A, et al. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 2000;14(13):2075-86.
    • (2000) FASEB J. , vol.14 , Issue.13 , pp. 2075-2086
    • Roth, W.1    Deussing, J.2    Botchkarev, V.A.3    Pauly-Evers, M.4    Saftig, P.5    Hafner, A.6
  • 32
    • 70350503333 scopus 로고    scopus 로고
    • Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)
    • Huckel M, Schurigt U, Wagner AH, Stockigt R, Petrow PK, Thoss K, et al. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther. 2006;8(1):R17.
    • (2006) Arthritis Res Ther , vol.8 , Issue.1
    • Huckel, M.1    Schurigt, U.2    Wagner, A.H.3    Stockigt, R.4    Petrow, P.K.5    Thoss, K.6
  • 33
    • 20144370643 scopus 로고    scopus 로고
    • The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4?CD25? T cells
    • Frey O, Petrow PK, Gajda M, Siegmund K, Huehn J, Scheffold A, et al. The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4?CD25? T cells. Arthritis Res Ther. 2005;7(2):R291-301.
    • (2005) Arthritis Res Ther , vol.7 , Issue.2
    • Frey, O.1    Petrow, P.K.2    Gajda, M.3    Siegmund, K.4    Huehn, J.5    Scheffold, A.6
  • 34
    • 0030015453 scopus 로고    scopus 로고
    • + T cells
    • Petrow PK, Thoss K, Katenkamp D, Brauer R. Adoptive transfer of susceptibility to antigen-induced arthritis into severe combined immunodeficient (SCID) mice: role of CD4? and CD8? T cells. Immunol Invest. 1996;25(4):341-53. (Pubitemid 26230600)
    • (1996) Immunological Investigations , vol.25 , Issue.4 , pp. 341-353
    • Petrow, P.K.1    Thoss, K.2    Katenkamp, D.3    Brauer, R.4
  • 35
    • 1542329511 scopus 로고    scopus 로고
    • Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: Influence on T helper cell activation
    • DOI 10.1111/j.1365-2249.2003.02381.x
    • Pohlers D, Nissler K, Frey O, Simon J, Petrow PK, Kinne RW, et al. Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation. Clin Exp Immunol. 2004;135(3):409-15. (Pubitemid 38297140)
    • (2004) Clinical and Experimental Immunology , vol.135 , Issue.3 , pp. 409-415
    • Pohlers, D.1    Nissler, K.2    Frey, O.3    Simon, J.4    Petrow, P.K.5    Kinne, R.W.6    Brauer, R.7
  • 36
    • 0034930528 scopus 로고    scopus 로고
    • Towards specific functions of lysosomal cysteine peptidases: Phenotypes of mice deficient for cathepsin B or cathepsin L
    • DOI 10.1515/BC.2001.089
    • Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem. 2001;382(5): 735-41. (Pubitemid 32631710)
    • (2001) Biological Chemistry , vol.382 , Issue.5 , pp. 735-741
    • Reinheckel, T.1    Deussing, J.2    Roth, W.3    Peters, C.4
  • 38
    • 70349969840 scopus 로고    scopus 로고
    • Regulatory T cells as therapeutic targets in rheumatoid arthritis
    • Esensten JH, Wofsy D, Bluestone JA. Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol. 2009;5(10):560-5.
    • (2009) Nat Rev Rheumatol. , vol.5 , Issue.10 , pp. 560-565
    • Esensten, J.H.1    Wofsy, D.2    Bluestone, J.A.3
  • 40
    • 77957855881 scopus 로고    scopus 로고
    • Specialized roles for cysteine cathepsins in health and disease
    • Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest. 2010;120(10): 3421-31.
    • (2010) J Clin Invest , vol.120 , Issue.10 , pp. 3421-3431
    • Reiser, J.1    Adair, B.2    Reinheckel, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.