Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis

Arthritis and Rheumatism

Volumn 41, Issue 8, 1998, Pages 1378-1387

  Keyszer, Gernot ^a   Redlich, Angela ^a   Häupl, Thomas ^a   Zacher, Josef ^b   Sparmann, Martin ^c   Ungethüm, Ute ^a   Gay, Steffen ^d   Burmester, Gerd R ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HELIOS KLINIKUM BERLIN BUCH   (Germany)

^c Immanuel Krankenhaus   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CYSTATIN; MATRIX METALLOPROTEINASE;

ADULT; AGED; ARTICLE; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM; TRANSCRIPTION REGULATION;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CATHEPSIN B; CATHEPSINS; CYSTATINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FEMALE; HUMANS; MALE; METALLOENDOPEPTIDASES; MIDDLE AGED; OSTEOARTHRITIS; PROTEASE INHIBITORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 0031829713     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199808)41:8<1378::AID-ART6>3.0.CO;2-J     Document Type: Article

References (44)

1. Burmester GR, Stuhlmüller B, Keyszer G, Kinne RW. Mononuclear phagocytes and rheumatoid synovitis: mastermind or workhorse in arthritis? Arthritis Rheum 1997;40:5-18.
2. Firestein GS. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors? Arthritis Rheum 1996;39:1781-90.
3. Cawston TE. Metalloproteinase inhibitors and the prevention of connective tissue breakdown. Pharmacol Ther 1996;70:163-82.
4. McCachren SS. Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium. Arthritis Rheum 1991;34:1085-93.
5. Firestein GS, Paine MM. Stromelysin and tissue inhibitor of metalloproteinase gene expression in rheumatoid arthritis synovium. Am J Pathol 1992;140:1309-14.
6. Firestein GS, Paine MM, Littman BH. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium: quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum 1991;34:1094-105.
7. Keyszer G, Heer AH, Gay S. Cytokines and oncogenes in cellular interactions of rheumatoid arthritis. Stem Cells 1994;12:75-86.
8. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Nilson Hamilton M, Hamilton RT, et al. Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/l mice and patients with rheumatoid arthritis. Matrix 1990;10:349-61.
9. Chambers AF, Collela R, Denhardt DT, Wilson SM. Increased expression of cathepsins L and B and decreased activity of their specific inhibitors in metastatic, ras-transformed NIH 3T3 cells. Mol Carcinog 1992;5:238-45.
10. Keyszer GM, Heer AH, Kriegsmann J, Geiler T, Trabandt A, Keysser M, et al. Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissue of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization. Arthritis Rheum 1995;38:976-84.
11. Trabandt A, Gay RE, Fassbender HG, Gay S. Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. Arthritis Rheum 1991;34:1444-51.
12. Iwata Y, Mort JS, Tateishi H, Lee ER. Macrophage eathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis. Arthritis Rheum 1997;40:499-509.
13. Abrahamson M, Olafsson I, Palsdottir A, Ulvsback M, Lundwall A, Jensson O, et al. Structure and expression of the human cystatin C gene. Biochem J 1990;268:287-94.
14. Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer JT, et al. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. Arthritis Rheum 1994;37:236-47.
15. Esser RE, Watts LM, Angelo RA, Thornburg LP, Prior JJ, Palmer JT. The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis. J Rheumatol 1993;20:1176-83.
16. Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases: evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum 1993;36: 1709-17.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
18. D'Aquila RT, Bechtel LJ, Videler JA, Eron JJ, Gorycza P, Kaplan JC. Maximizing sensitivity and specificity of PCR by pre-amplification heating. Nucleic Acids Res 1991;19:374-9.
19. Geiler G. Möglichkeiten und Grenzen der morphologischen Diagnostik der Rheumatoidarthritis (Feasibilities and limitations of morphological diagnostic in rheumatoid arthritis). Zschr Inn Med 1976;16:615-23.
20. Fassbender HG, Gay S. Synovial processes in rheumatoid arthritis. Scand J Rheumatol Suppl 1988;76:1-7.
21. Roughley PJ, Barrett AJ. The degradation of cartilage proteoglycans by tissue proteinases: proteoglycan structure and its susceptibility to proteolysis. Biochem J 1977;167:629-37.
22. Nguyen Q, Mort JS, Roughley PJ. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem J 1990;266:569-73.
23. Baumgrass R, Williamson MK, Price PA. Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S. J Bone Miner Res 1997;12:447-55.
24. Mort JS, Recklies AD, Poole AR. Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH. Arthritis Rheum 1984;27:509-15.
25. Baici A, Hörler D, Lang A, Merlin C, Kissling R. Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage. Ann Rheum Dis 1995;54:281-8.
26. Eeckhout Y, Vaes G. Further studies on the activation of procollagenase, the latent precursor of bone collagenase: effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation. Biochem J 1977;166:21-31.
27. Murphy G, Ward R, Gavrilovic J, Atkinson S. Physiological mechanisms for metalloproteinase activation. Matrix 1992;1 Suppl:224-30.
28. Abrahamson M, Grubb A, Olafsson I, Lundwall A. Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C. FEBS Lett 1987;216:229-33.
29. Lenarcic B, Gabrijelcic D, Rozman B, Drobnic Kosorok M, Turk V. Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases. Biol Chem 1988;369 Suppl:257-61.
30. Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH. In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum 1991;34:1076-84.
31. Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in rheumatoid synovium: a transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol 1989;135:1055-64.
32. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI. Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression. J Biol Chem 1990;265: 17238-45.
33. Duffy JM, Walker B, Guthrie D, Grimshaw J, McNally G, Grimshaw JT, et al. The detection, quantification and partial characterisation of cathepsin B-like activity in human pathological synovial fluids. Eur J Clin Chem Clin Biochem 1994;32:429-34.
34. Keppler D, Waridel P, Abrahamson M, Bachmann D, Berdoz J, Sordat B. Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase. Biochim Biophys Acta 1994;1226: 117-25.
35. Lecomte V, Knott I, Remade J, Raes M. Cathepsin B and N-acetyl-beta-D-glucosaminidase in human synovial cells in culture: effects of interleukin-1. Clin Chim Acta 1994;228:143-59.
36. Huet G, Flipo R-M, Colin C, Janin A, Hemon B, Collyn-d'Hooghe M, et al. Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor a and interleukin-1. Arthritis Rheum 1993;36:772-80.
37. Lemaire R, Huet G, Zerimech F, Grard G, Fontaine C, Duquesnoy B, et al. Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells. Br J Rheumatol 1997;36:735-43.
38. Mehraban F, Tindal MH, Proffitt MM, Moskowitz RW. Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion. Ann Rheum Dis 1997;56:108-15.
39. Qian F, Frankfater A, Chan SJ, Steiner DF. The structure of mouse cathepsin B gene and its putative promoter. DNA Cell Biol 1991;10:531-40.
40. Lah TT, Hawley M, Rock KL, Goldberg AL. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett 1995;363:85-9.
41. Firestein GS, Alvaro Gracia JM, Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 1990;144:3347-53.
42. Simon AK, Seipelt E, Sieper J. Divergent T-cell cytokine patterns in inflammatory arthritides. Proc Natl Acad Sci U S A 1994;91: 8562-6.
43. Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girtra NN, et al. Inhibition of stromelysin-1 (MMP-3) by P1-biphenylethyl carboxyalkyl dipeptides. J Med Chem 1997;40:1026-40.
44. Boyle DL, Sajjadi FG, Firestein GS. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum 1996;39:923-30.